Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jaime Kapitulnik"'
Autor:
Fabián Pelusa, Sandra Mónica María Arriaga, Cecilia Lorena Basiglio, Adriana M. Almará, Aldo D. Mottino, Jaime Kapitulnik
Publikováno v:
Clinical Science. 118:99-113
Complement, an important effector mechanism of the immune system, is an enzymatic cascade of approx. 30 serum proteins leading to the amplification of a specific humoral response. It can be activated through the classical or alternative pathways, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6228af3f0d622f2b5c29bfaed2d81629
https://doi.org/10.1042/cs20080540
https://doi.org/10.1042/cs20080540
Publikováno v:
Critical Reviews in Toxicology. 38:697-720
The linkage point between kinetics and dynamics of drugs and other foreign chemicals is at the active site of the target. The response is determined within certain limits by the concentration of the substance at the target and its mechanism of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914d78169ceceed404ef08ca4f62af60
https://doi.org/10.1080/10408440802194931
https://doi.org/10.1080/10408440802194931
Autor:
Jaime Kapitulnik
Publikováno v:
Molecular Pharmacology. 66:773-779
Bilirubin is a linear tetrapyrrole that is formed during the process of heme degradation. Heme is released from a series of hemeproteins, including hemoglobin and cytochrome P450, and metabolized by heme oxygenase to form carbon monoxide, biliverdin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::807e15e19247b36f896983b1ddfab683
https://doi.org/10.1124/mol.104.002832
https://doi.org/10.1124/mol.104.002832
Autor:
Henry W. Strobel, Jaime Kapitulnik
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 13:227-230
Drug metabolizing enzymes are known to be present and active in most extrahepatic tissues. In this review, evidence is presented that expression and activity of several extrahepatic drug-metabolizing enzymes are regulated in unique ways, which may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0819e6c79aef16de63fb8dde25f6021e
https://doi.org/10.1002/(sici)1099-0461(1999)13:5<227::aid-jbt1>3.0.co
https://doi.org/10.1002/(sici)1099-0461(1999)13:5<227::aid-jbt1>3.0.co
Publikováno v:
Pediatric Research. 40:209-214
Bilirubin encephalopathy results from the entry of bilirubin into the brain and is expressed by motor, sensory, and/or behavioral impairment. The jaundiced (jj) Gunn rat is a valuable animal model for studying the kinetics of bilirubin-induced neurot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3694c122afa0a9b3e355568ec18a58b5
https://doi.org/10.1203/00006450-199608000-00005
https://doi.org/10.1203/00006450-199608000-00005
Publikováno v:
Pediatric Research. 38:258-261
The manifestations of bilirubin encephalopathy include disturbances in the visual pathway (visual gaze paralysis and distorted visual perception). In the young jaundiced Gunn rat (jj) model of hyperbilirubinemia, significant differences in visual evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f248012cd6fed8acf3389e4c2cb532
https://doi.org/10.1203/00006450-199508000-00020
https://doi.org/10.1203/00006450-199508000-00020
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Frontiers in Pharmacology
Frontiers in Pharmacology
Unconjugated bilirubin (UCB) is a neurotoxic degradation product of heme. Its toxic effects include induction of apoptosis, and ultimately neuronal cell death. However, at low concentrations, UCB is a potent antioxidant that may protect cells and tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc37bfaa2778e05c855a1c3f0d7f8a1e
http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00131/full
http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00131/full
Autor:
Jaime Kapitulnik, Mahin D. Maines
Publikováno v:
The role of bile pigments in health and disease: effects on cell signaling, cytotoxicity and cytoprotection
Frontiers in Pharmacology, Vol 3 (2012)
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 3 (2012)
Frontiers in Pharmacology
Degradation of heme involves its conversion to biliverdin by heme oxygenase followed by reduction of biliverdin to bilirubin by biliverdin reductase. There is ample evidence for the role of heme oxygenase in protecting cells from the toxic effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0c8fc3fd01e45f0b7ae654bf6c48f2
https://doi.org/10.3389/fphar.2012.00136
https://doi.org/10.3389/fphar.2012.00136
Autor:
Jaime Kapitulnik
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 2 (2011)
Frontiers in Pharmacology, Vol 2 (2011)
Despite recent advances, the treatment of brain diseases and neurological disorders, such as the Parkinson and Alzheimer syndromes, multiple sclerosis, brain cancer, psychiatric disorders, many forms of epilepsy, chronic pain, and migraine, remains a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791c67110da00d05e31f88ae6e4f5092
https://doi.org/10.3389/fphar.2011.00037
https://doi.org/10.3389/fphar.2011.00037
Publikováno v:
Expert opinion on therapeutic targets. 13(7)
Biologically active molecules, that is pharmaceuticals and other chemical substances, exert their therapeutic and/or toxic effects by complex interactions with their biological targets/active sites. This review discusses the factors and processes gov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709afda83d11aa04163499172549ecd1
https://pubmed.ncbi.nlm.nih.gov/19530989
https://pubmed.ncbi.nlm.nih.gov/19530989