The Anaesthetics Isoflurane and Xenon Reverse the Synaptotoxic Effects of Aβ1–42 on Megf10-Dependent Astrocytic Synapse Elimination and Spine Density in Ex Vivo Hippocampal Brain Slices

Autor: Dai Shi, Jaime K. Y. Wong, Kaichuan Zhu, Peter G. Noakes, Gerhard Rammes

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 912
International journal of molecular sciences 24(2), 912 (2023). doi:10.3390/ijms24020912

It has been hypothesised that inhalational anaesthetics such as isoflurane (Iso) may trigger the pathogenesis of Alzheimer’s disease (AD), while the gaseous anaesthetic xenon (Xe) exhibits many features of a putative neuroprotective agent. Loss of

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