Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jaime Cheah"'
Autor:
Guangan Hu, Yang Su, Byong Ha Kang, Zhongqi Fan, Ting Dong, Douglas R. Brown, Jaime Cheah, Karl Dane Wittrup, Jianzhu Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Macrophages may polarize into different states with distinct regulatory functions for inflammation. Here the authors perform high-throughput in vitro screening of a library of ~4000 compounds to identify those with specific effects on human macrophag
Externí odkaz:
https://doaj.org/article/1550a867bc7a4e05979cb68615b93744
Autor:
Sourav Bandyopadhyay, Andrei Goga, Frank McCormick, Kevan M. Shokat, Nevan J. Krogan, Stuart L. Schreiber, Alykhan F. Shamji, Paul A. Clemons, Jaime Cheah, Antonio Sorrentino, Mike Shales, John Jascur, Jeff Johnson, Rebecca S. Levin, John D. Gordan, Taha Rakhshandehroo, Christina Yau, Dai Horiuchi, Alexandra Corella, Alicia Y. Zhou, Maria M. Martins
Supplementary Table S2. Drugs and their concentrations used in the isogenic drug screen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ceecba2ea240f6046b9bdcfe401f9a2
https://doi.org/10.1158/2159-8290.22529895.v1
https://doi.org/10.1158/2159-8290.22529895.v1
Autor:
Sourav Bandyopadhyay, Andrei Goga, Frank McCormick, Kevan M. Shokat, Nevan J. Krogan, Stuart L. Schreiber, Alykhan F. Shamji, Paul A. Clemons, Jaime Cheah, Antonio Sorrentino, Mike Shales, John Jascur, Jeff Johnson, Rebecca S. Levin, John D. Gordan, Taha Rakhshandehroo, Christina Yau, Dai Horiuchi, Alexandra Corella, Alicia Y. Zhou, Maria M. Martins
Supplementary Figure 1. Distribution of gene alterations in Breast TCGA and verification of expression of MCF10A cells. Supplementary Figure 2. Analysis of the MCF10A drug screen. Supplementary Figure 3. Significance of overlap between interactions f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02486064772f8aab6c1c615417b162ea
https://doi.org/10.1158/2159-8290.22529901
https://doi.org/10.1158/2159-8290.22529901
Autor:
Joelle Straehla, Natalie Boehnke, Hannah Safford, Mustafa Kocak, Matthew Rees, Melissa Ronan, Danny Rosenberg, Jaime Cheah, Jennifer Roth, Angela Koehler, Paula Hammond
Publikováno v:
Neuro-Oncology. 24:vii97-vii97
Background There is great interest in utilizing nanoparticles to improve drug delivery to central nervous system (CNS) tumors, but the biologic features underlying successful delivery at the tumor site are not known. METHODS We developed a pooled scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1986b7f50c1ca7c41e4b9107fdda70f0
https://doi.org/10.1093/neuonc/noac209.363
https://doi.org/10.1093/neuonc/noac209.363
Autor:
Jianzhu Chen, Jaime Cheah, Douglas Brown, Ting Dong, Yang Su, Karl Dane Wittrup, Guangan Hu, Byong Ha Kang, Zhongqi Fan
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Macrophages are plastic and, in response to different local stimuli, can polarize toward multi-dimensional spectrum of phenotypes, including the pro-inflammatory M1-like and the anti-inflammatory M2-like states. Using a high-throughput phenotypic scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977f1eaa1e7d5a39240abf8b5de5d043
http://europepmc.org/articles/PMC7858590
http://europepmc.org/articles/PMC7858590
Autor:
Stuart L. Schreiber, John D. Gordan, Frank McCormick, Alykhan F. Shamji, Christina Yau, Kevan M. Shokat, Dai Horiuchi, Andrei Goga, Sourav Bandyopadhyay, Maria M. Martins, Michael Shales, Jeffrey R. Johnson, Paul A. Clemons, Jaime Cheah, Nevan J. Krogan, Alicia Y. Zhou, Taha Rakshandehroo, John Jascur, Rebecca S. Levin, Alexandra Corella, Antonio Sorrentino
Publikováno v:
Cancer discovery, vol 5, iss 2
There is an urgent need in oncology to link molecular aberrations in tumors with therapeutics that can be administered in a personalized fashion. One approach identifies synthetic–lethal genetic interactions or dependencies that cancer cells acquir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d90e9796b9325d9729faa32d965764
https://pubmed.ncbi.nlm.nih.gov/30076145
https://pubmed.ncbi.nlm.nih.gov/30076145
Autor:
Anson Peng, Levi A. Garraway, Stuart L. Schreiber, Adi F. Gazdar, William C. Hahn, Jesse S. Boehm, Aviad Tsherniak, Abeer Sayeed, Shubhroz Gill, Paul A. Clemons, Jaime Cheah, Yuen-Yi Tseng, Rebecca Deasy, Francisca Vazquez, Adam J. Bass, Todd R. Golub, Katherine A. Janeway, Paula Keskula, Keith L. Ligon, Peter Ronning, Nikhil Wagle, Andrew L. Hong, Mark A. Rubin, Srivatsan Raghavan, Philip W. Kantoff, Sahar Alkhairy, Calvin J. Kuo, Sidharth V. Puram, David E. Root
Publikováno v:
Molecular Cancer Therapeutics. 16:A02-A02
The development of new cancer therapeutics requires sufficient genetic and phenotypic diversity of cancer models. Current collections of human cancer cell lines are limited and for many rare cancer types, zero models exist that are broadly available.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::788fd94937cba7356cb738c5240484b3
https://doi.org/10.1158/1538-8514.synthleth-a02
https://doi.org/10.1158/1538-8514.synthleth-a02
Autor:
Yuen-Yi Tseng, Andrew Hong, Paula Keskula, Shubhroz Gill, Jaime Cheah, Grigoriy Kryukov, Aviad Tsherniak, Francisca Vazquez, Glenn Cowley, Sahar Alkhairy, Coyin Oh, Anson Peng, Rebecca Deasy, Abeer Sayeed, Peter Ronning, Samuel Ng, Steven Corsello, Corrie Painter, David Sandak, Levi Garraway, Mark Rubin, Calvin Kuo, Sidharth Puram, David Weinstock, Adam Bass, Nikhil Wagle, Keith Ligon, Katherine Janeway, David Root, Stuart Schreiber, Paul Clemons, Aly Shamji, William Hahn, Todd Golub, Jesse Boehm
Publikováno v:
Cancer Research. 77:1953-1953
Ongoing pre-clinical efforts aim to deploy genome-scale CRISPR/Cas9 technology and large collections of small molecules to catalog maps of cancer vulnerabilities at scale. However, such efforts in pediatric and rare cancers have lagged behind compara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0f1b07f54ecaa061153b31e5f31d02c
https://doi.org/10.1158/1538-7445.am2017-1953
https://doi.org/10.1158/1538-7445.am2017-1953
Autor:
Oliver Jonas, William C. Hahn, Mihir B. Doshi, Jesse S. Boehm, Robert Langer, Andrew L. Hong, Glenn S. Cowley, Stuart L. Schreiber, Michael J. Cima, Jaime Cheah, Bryan D. Kynnap, Yuen-Yi Tseng, Coyin Oy, Gregory V. Kryukov, David E. Root, Paula Keskula
Publikováno v:
Clinical Cancer Research. 22:PR04-PR04
Loss-of-function screening using RNAi technologies over the past decade and more recently with CRISPR-Cas9 technologies have been applied to well-established cancer models. We asked if minimally passaged cancer models would tolerate such screening mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d90e98320d7f89974b6ba1b726339661
https://doi.org/10.1158/1557-3265.pdx16-pr04
https://doi.org/10.1158/1557-3265.pdx16-pr04
Autor:
Paula Keskula, Filemon S. Dela Cruz, Peter Ronning, Nikhil Wagle, Levi A. Garraway, Andrew L. Hong, Todd R. Golub, Adi F. Gazdar, Paul A. Clemons, William C. Hahn, Mark A. Rubin, David E. Root, Philip W. Kantoff, Stuart L. Schreiber, Anson Peng, Aviad Tsherniak, Sidharth V. Puram, Jesse S. Boehm, Grigoriy Kryukov, Jaime Cheah, Abeer Sayeed, Shubhroz Gill, Adam J. Bass, Katherine A. Janeway, Yuen-Yi Tseng, Rebecca Deasy, Aly Shamji, Glenn S. Cowley, Francisca Vazquez, Calvin J. Kuo, Keith L. Ligon, Coyin Oh
Publikováno v:
Cancer Research. 76:4367-4367
The mapping of cancer genomes is rapidly approaching completion. The genomic information encoded by individual patients’ tumors should, in principle, provide a guide for predicting dependencies, but our ability to do so is suboptimal. The challenge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cf9ddd3e78e8a28ad5fb8a59935323f
https://doi.org/10.1158/1538-7445.am2016-4367
https://doi.org/10.1158/1538-7445.am2016-4367