Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Jaime Charris"'
Autor:
Joyce E. Gutiérrez, Esteban Fernandez-Moreira, Miguel A. Rodríguez, Michael R. Mijares, Juan Bautista De Sanctis, Soňa Gurská, Petr Džubák, Marián Hajdůch, Julia Bruno-Colmenarez, Luis Rojas, Denis Deffieux, Laurent Pouységu, Stéphane Quideau, Jaime Charris, Hegira Ramírez
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1234 (2022)
A series of 78 synthetic 7-chloro-(4-thioalkylquinoline) derivatives were investigated for cytotoxic activity against eight human cancer as well as 4 non-tumor cell lines. The results showed, with some exceptions, that sulfanyl 5–40 and sulfinyl 41
Externí odkaz:
https://doaj.org/article/ec01600f92cc479f85cac12e2bcbc218
Autor:
Hegira Ramírez, Katiuska Charris, Esteban Fernandez-Moreira, Benjamín Nogueda-Torres, Mario V. Capparelli, Jorge Ángel, Jaime Charris
Publikováno v:
Molecules, Vol 26, Iss 22, p 6977 (2021)
Several methoxybenzo[h]quinoline-3-carbonitrile analogs were designed and synthesized in a repositioning approach to developing compounds with anti-prostate cancer and anti-Chagas disease properties. The compounds were synthesized through a sequentia
Externí odkaz:
https://doaj.org/article/0f2d6485eb5242a790cfbcc301783a96
Autor:
Yonathan de Jesus Parra, Rosa Elena Ferrer, Julia Bruno-Colmenarez, Jaime Charris, Gricela Lobo, Neira Gamboa de Domínguez, Philip J. Rosenthal, Jiri Gut
Publikováno v:
Orbital: The Electronic Journal of Chemistry, Vol 9, Iss 4, Pp 308-314 (2017)
A simple synthesis and study by UV-vis, IR, NMR, ESI-CID-MS2 and X-ray diffraction of ((2E)-2-(1-{4-[(7-chloroquinolin-4-yl)amino]phenyl}ethylidene)hydrazinecarbothioamide is reported. It was tested in vitro against chloroquine-resistant strain (W2)
Externí odkaz:
https://doaj.org/article/6c062354ade9479ea7227361d43c7a05
Autor:
Gricela Lobo, Jaime Charris, Antonieta Taddei, Melina Monas, Margaret Valderrama, Jesús Romero, Katiuska Charris
Publikováno v:
Avances en Química, Vol 7, Iss 2, Pp 119-128 (2012)
A new synthesis of novel 4,6-diaminopyrimidines 2a-j, cytosine analogous, is described. This involves the base-assisted cyclization reaction of benzylidenemalononitriles 1a-j (BMNs) with urea. Compounds 1a-j were prepared by a Knoevenagel condensatio
Externí odkaz:
https://doaj.org/article/30c058aa0204421884f792e62016a44b
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 104, Iss 6, Pp 865-870 (2009)
E-2-chloro-8-methyl-3-[(4'-methoxy-1'-indanoyl)-2'-methyliden]-quinoline (IQ) is a new quinoline derivative which has been reported as a haemoglobin degradation and ß-haematin formation inhibitor. The haemoglobin proteolysis induced by Plasmodium pa
Externí odkaz:
https://doaj.org/article/dc1a07165da940469e9b9825d03f3563
Autor:
Carmen E Contreras, María A Rivas, José Domínguez, Jaime Charris, Mario Palacios, Nicolás E Bianco, Isaac Blanca
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 99, Iss 2, Pp 179-184 (2004)
The evaluation of new antimalarial agents using older methods of monitoring sensitivity to antimalarial drugs are laborious and poorly suited to discriminate stage-specific activity. We used flow cytometry to study the effect of established antimalar
Externí odkaz:
https://doaj.org/article/1b42b88d2d2a4e1bab0b388c2f619be2
Publikováno v:
Molbank, Vol 2010, Iss 3, p M693 (2010)
A new compound, 4,6-diamino-5-(3,4-dichlorobenzylidene)pyrimidin-2(5H)-one, was synthesized and its IR, 1H NMR,13C NMR, MS spectroscopic data and elemental analysis are presented.
Externí odkaz:
https://doaj.org/article/389b4a8d7d344dccbbe8a0e2eee6f7ab
Autor:
Cristina Castelli, Jesús Romero, Margaret Valderrama, Jaime Charris, Gricela Lobo, Antonieta Taddei
Publikováno v:
Molbank, Vol 2010, Iss 1, p M653 (2010)
A new compound, 4,6-diamino-5-(methylbenzylidene)pyrimidin-2(5H)-one, was synthesized and its IR, 1H NMR,13C NMR and MS spectroscopic data are presented.
Externí odkaz:
https://doaj.org/article/58605752bf63490fb981e12d3fa556dc
Publikováno v:
Molbank, Vol 2009, Iss 3, p M615 (2009)
A new compound, 4,6-diamino-5-[4-(dimethylamino)benzylidene]pyrimidin-2(5H)-one, was synthesized and its IR, 1H NMR and 13C NMR and MS spectroscopic data are presented.
Externí odkaz:
https://doaj.org/article/19e9740337e3438180bf80cb4331799c
Autor:
Michael Rodney Mijares, Juan Bautista De Sanctis, Jaime Charris, Zuleyma Blanco, Hegira Ramírez, Gricelis Patricia Martínez
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 23:1122-1144
Abstract: Tumour relapse, chemotherapy resistance, and metastasis continue to be unsolved issues in cancer therapy. A recent approach has been to scrutinise drugs used in the clinic for other illnesses and modify their structure to increase selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d5f714a77ce90a7e4d455124ed6730
https://doi.org/10.2174/1871520622666220519102948
https://doi.org/10.2174/1871520622666220519102948