Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Jaime Charris"'
Autor:
Michael Rodney Mijares, Juan Bautista De Sanctis, Jaime Charris, Zuleyma Blanco, Hegira Ramírez, Gricelis Patricia Martínez
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 23:1122-1144
Abstract: Tumour relapse, chemotherapy resistance, and metastasis continue to be unsolved issues in cancer therapy. A recent approach has been to scrutinise drugs used in the clinic for other illnesses and modify their structure to increase selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d5f714a77ce90a7e4d455124ed6730
https://doi.org/10.2174/1871520622666220519102948
https://doi.org/10.2174/1871520622666220519102948
Autor:
Joyce E. Gutiérrez, Esteban Fernandez-Moreira, Miguel A. Rodríguez, Michael R. Mijares, Juan Bautista De Sanctis, Soňa Gurská, Petr Džubák, Marián Hajdůch, Julia Bruno-Colmenarez, Luis Rojas, Denis Deffieux, Laurent Pouységu, Stéphane Quideau, Jaime Charris, Hegira Ramírez
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1234 (2022)
A series of 78 synthetic 7-chloro-(4-thioalkylquinoline) derivatives were investigated for cytotoxic activity against eight human cancer as well as 4 non-tumor cell lines. The results showed, with some exceptions, that sulfanyl 5–40 and sulfinyl 41
Externí odkaz:
https://doaj.org/article/ec01600f92cc479f85cac12e2bcbc218
Autor:
Hegira Ramírez, Katiuska Charris, Esteban Fernandez-Moreira, Benjamín Nogueda-Torres, Mario V. Capparelli, Jorge Ángel, Jaime Charris
Publikováno v:
Molecules, Vol 26, Iss 22, p 6977 (2021)
Several methoxybenzo[h]quinoline-3-carbonitrile analogs were designed and synthesized in a repositioning approach to developing compounds with anti-prostate cancer and anti-Chagas disease properties. The compounds were synthesized through a sequentia
Externí odkaz:
https://doaj.org/article/0f2d6485eb5242a790cfbcc301783a96
Autor:
Yonathan de Jesus Parra, Rosa Elena Ferrer, Julia Bruno-Colmenarez, Jaime Charris, Gricela Lobo, Neira Gamboa de Domínguez, Philip J. Rosenthal, Jiri Gut
Publikováno v:
Orbital: The Electronic Journal of Chemistry, Vol 9, Iss 4, Pp 308-314 (2017)
A simple synthesis and study by UV-vis, IR, NMR, ESI-CID-MS2 and X-ray diffraction of ((2E)-2-(1-{4-[(7-chloroquinolin-4-yl)amino]phenyl}ethylidene)hydrazinecarbothioamide is reported. It was tested in vitro against chloroquine-resistant strain (W2)
Externí odkaz:
https://doaj.org/article/6c062354ade9479ea7227361d43c7a05
Autor:
Angel H. Romero, Elena Aguilera, Lourdes Gotopo, Jaime Charris, Noris Rodríguez, Henry Oviedo, Belén Dávila, Gustavo Cabrera, Hugo Cerecetto
Publikováno v:
ACS omega. 7(50)
Nitric oxide (NO) represents a valuable target to design antitrypanosomal agents by its high toxicity against trypanosomatids and minimal side effects on host macrophages. The progress of NO-donors as antitrypanosomal has been restricted by the high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3325b317384d09066587a6ac6d6b3b6
https://pubmed.ncbi.nlm.nih.gov/36570252
https://pubmed.ncbi.nlm.nih.gov/36570252
Autor:
Henry Oviedo, Zuleima Blanco, Michael Mijares, Esteban Fernandez-Moreira, Jaime Charris, Hegira Ramírez, Noris Rodríguez
Publikováno v:
Parasitology Research. 120:3307-3317
The aim of this study was to synthesize several small molecules of the type 5-nitroimidazole-sulfanyl and evaluate biological properties against the main Leishmania species that cause cutaneous leishmaniasis in Venezuela. Final compounds 4-7 were gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f127a67daee9be42abe72f2bbfa033
https://doi.org/10.1007/s00436-021-07266-w
https://doi.org/10.1007/s00436-021-07266-w
Publikováno v:
Current Pharmaceutical Design. 26:4467-4485
Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of the heterocyclic aromatic compound quinoline. These economical compounds have been used as antimalarial agents for many years. Currently, they are used as monotherapy or in conjunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b860d9d17a30fe0a5f365fa81b763fc9
https://doi.org/10.2174/1381612826666200707132920
https://doi.org/10.2174/1381612826666200707132920
Publikováno v:
Journal of Chemical Research. 44:305-314
A novel series of 2-[2-(7-chloroquinolin-4-ylthio)-4-methylthiazol-5-yl]- N-phenylacetamide derivatives is synthesized via substitution with 2-mercapto-4-methyl-5-thiazoleacetic acid at position 4 of 4,7-dichloroquinoline to obtain an intermediate ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::089238509e0379e4404195b31c95e37e
https://doi.org/10.1177/1747519819899073
https://doi.org/10.1177/1747519819899073
Autor:
Gricela Lobo, Jaime Charris, Antonieta Taddei, Melina Monas, Margaret Valderrama, Jesús Romero, Katiuska Charris
Publikováno v:
Avances en Química, Vol 7, Iss 2, Pp 119-128 (2012)
A new synthesis of novel 4,6-diaminopyrimidines 2a-j, cytosine analogous, is described. This involves the base-assisted cyclization reaction of benzylidenemalononitriles 1a-j (BMNs) with urea. Compounds 1a-j were prepared by a Knoevenagel condensatio
Externí odkaz:
https://doaj.org/article/30c058aa0204421884f792e62016a44b
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 104, Iss 6, Pp 865-870 (2009)
E-2-chloro-8-methyl-3-[(4'-methoxy-1'-indanoyl)-2'-methyliden]-quinoline (IQ) is a new quinoline derivative which has been reported as a haemoglobin degradation and ß-haematin formation inhibitor. The haemoglobin proteolysis induced by Plasmodium pa
Externí odkaz:
https://doaj.org/article/dc1a07165da940469e9b9825d03f3563