Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jaime Blanco-Urgoiti"'
Autor:
Marcos Vilariño, Josune García-Sanmartín, Laura Ochoa-Callejero, Alberto López-Rodríguez, Jaime Blanco-Urgoiti, Alfredo Martínez
Publikováno v:
Molecules, Vol 25, Iss 24, p 6010 (2020)
Mushrooms have been used for millennia as cancer remedies. Our goal was to screen several mushroom species from the rainforests of Costa Rica, looking for new antitumor molecules. Mushroom extracts were screened using two human cell lines: A549 (lung
Externí odkaz:
https://doaj.org/article/ce62f5344d664d7ba9aea86215e9e240
Autor:
Alfredo Martínez, Jaime Blanco-Urgoiti, Alberto López-Rodríguez, Laura Ochoa-Callejero, Josune García-Sanmartín, Marcos Vilariño
Mushrooms have been used for millennia as cancer remedies. Our goal was to screen several species from the rain forest of Costa Rica looking for new antitumor molecules. Mushroom extracts were screened using two human cell lines: A549 (lung adenocarc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::312f57d0f521ccb395261e3f7e658b07
https://doi.org/10.1101/2020.12.10.418863
https://doi.org/10.1101/2020.12.10.418863
Publikováno v:
Organicbiomolecular chemistry. 17(43)
A new synthesis of treprostinil is described using a plug flow reactor in two of the key steps. First, a Claisen rearrangement reaction is described in scaled flow at multigram amounts. Yields and selectivity of this step are sharply improved compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0625b18b116048fed0ec9de300c87687
https://pubmed.ncbi.nlm.nih.gov/31651921
https://pubmed.ncbi.nlm.nih.gov/31651921
Publikováno v:
Organic letters. 20(17)
Cobalt-catalyzed alkyne cyclotrimerization and crossed [2 + 2 + 2] cycloadditions are developed in a plug flow reactor. The protocol generally uses 5 mol % of Co2(CO)8 and is scalable at least at multigram scale. Efficient and scalable use of Co2(CO)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c358b97920c4db99d06897a4bd399d6
https://pubmed.ncbi.nlm.nih.gov/30125114
https://pubmed.ncbi.nlm.nih.gov/30125114
Publikováno v:
Molecular Nutrition & Food Research. 63:1900110
Scope To identify the age-dependent effect of diets containing elevated amounts of either saturated or unsaturated fatty acids on cardiac steatosis in mice. Methods and results Five- and eight-week-old C57BL/6J mice cohorts are given free access to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e124e290ff7ea1f347bb41fc1fa7771c
https://doi.org/10.1002/mnfr.201900110
https://doi.org/10.1002/mnfr.201900110
Autor:
Javier Pérez-Castells, Delbrin Abdi, Marta Rosillo, Jaime Blanco-Urgoiti, Gema Domínguez, Eduardo Arnaiz
Publikováno v:
European Journal of Organic Chemistry. 2008:3917-3927
The combination of ring-closing metathesis (RCM) followed by an intramolecular Pauson–Khand reaction gives direct entry to tricyclic compounds. The RCM was carried out on a hexacarbonylcobalt-complexed alkyne, this complex acting as a protecting gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f854e48f5182c410b90e7db77936d9d8
https://doi.org/10.1002/ejoc.200800332
https://doi.org/10.1002/ejoc.200800332
Publikováno v:
Journal of Organometallic Chemistry. 693:2431-2437
Construction of quaternary carbons is a challenge in PK chemistry, with few precedents in the literature. Starting from suitable functionalized enynes including an aromatic ring that templates the reaction, polycyclic ketones are obtained with a quat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fe7321e62646cac54b58e66ebda66b7
https://doi.org/10.1016/j.jorganchem.2008.04.023
https://doi.org/10.1016/j.jorganchem.2008.04.023
Publikováno v:
Tetrahedron. 64:67-74
New experimental conditions have been developed for an efficient catalytic Pauson–Khand reaction. These are based on the use of a mixture of molecular sieves and tert -butanol as inducers of the process. This mixture, with the appearance of a paste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fb13575cb43f63ebec85e7a11366f10
https://doi.org/10.1016/j.tet.2007.10.089
https://doi.org/10.1016/j.tet.2007.10.089
Autor:
James A. Monn, Rosario Gonzalez, Sherri L. Andis, Concepción Pedregal, Beatriz López de Uralde, Bryan G. Johnson, Ivan Collado, Rebecca A. Wright, Darryle D. Schoepp, M. Alejandro Fernandez, Jaime Blanco-Urgoiti, Luisa Maria Martin-Cabrejas, Alicia Marcos, Javier Pérez-Castells
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:6556-6570
The synthesis of a series of C3'-cis-substituted carboxycyclopropyl glycines bearing a wide variety of functional groups is described, and the structure-activity relationship for this series as agonists of group II metabotropic glutamate receptors is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b700ad2e63dc126bf3547900d4f4171
https://doi.org/10.1016/j.bmc.2005.07.036
https://doi.org/10.1016/j.bmc.2005.07.036
Autor:
and Lea M. Johnson, Bryan D. Anderson, Paul Lee, Miriam del Prado, C. Richard NevillJr., Sehila Pleite, Yong Wang, † Jaime Blanco-Urgoiti, Luisa M. Martín Cabrejas, Jeremy Schulenburg York, Robert M. Campbell, Deborah D. Giera, Michal Vieth, Jeffrey A. Wolos, Denis J. McCann, Chuan Shih, Li C. Li, Beatriz López de Uralde, Nicholas A. Magnus, Concepción Sánchez, Rosanne Bonjouklian, Richard M. Schultz, María José Lorite, Alfonso De Dios
Publikováno v:
Journal of Medicinal Chemistry. 48:2270-2273
We report the design and discovery of a 2-aminobenzimidazole-based series of potent and highly selective p38alphainhibitors. The lead compound 1 had low-nanomolar activity in both ATP competitive enzyme binding and inhibition of TNFalpha release in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c105a28691f426c1b73e9b9ed314fcb
https://doi.org/10.1021/jm048978k
https://doi.org/10.1021/jm048978k