Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Jaime Altcheh"'
Autor:
Guillermo Moscatelli, Samanta Moroni, Juan Carlos Ramírez, Belén Warszatska, Lascano Fernanda, Nicolás González, Andrés Rabinovich, Jaime Altcheh
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 1, p e0011895 (2024)
BackgroundIn regions with controlled vector transmission of T. cruzi, congenital transmission is the most frequent route of infection. Treatment with benznidazole (BZ) or nifurtimox (NF) for 60 days in girls and women of childbearing age showed to be
Externí odkaz:
https://doaj.org/article/a9356bbb1e534506abc964012e4bbd97
Autor:
Manuel Abal, Virginia Balouz, Rosana Lopez, M Eugenia Giorgi, Carla Marino, Cintia V Cruz, Jaime Altcheh, Carlos A Buscaglia
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 1, p e0011910 (2024)
BackgroundProper evaluation of therapeutic responses in Chagas disease is hampered by the prolonged persistence of antibodies to Trypanosoma cruzi measured by conventional serological tests and by the lack of sensitivity of parasitological tests. Pre
Externí odkaz:
https://doaj.org/article/436e2323601a44e38bce9b228f04d4e9
Autor:
Alejandro D. Ricci, Leonel Bracco, Emir Salas-Sarduy, Janine M. Ramsey, Melissa S. Nolan, M. Katie Lynn, Jaime Altcheh, Griselda E. Ballering, Faustino Torrico, Norival Kesper, Juan C. Villar, Iván S. Marcipar, Jorge D. Marco, Fernán Agüero
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
This work reveals the diversity and extent of human antibody specificities in Chagas disease and provides a wealth of well-defined antigenic markers for diagnosis and development of serological applications for this neglected infectious disease.
Externí odkaz:
https://doaj.org/article/ef44d0c123244e7894dd34b27c90789c
Autor:
Maria-Jesus Pinazo, Colin J. Forsyth, Constanza Lopez-Albizu, Margarita María Catalina Bisio, Adriana González-Martínez, Laura Bohorquez, Jimy Pinto, Israel Molina, Andrea Marchiol, Rafael Herazo, Irene Losada Galván, Tayná Marques, Fabiana Barreira, Juan Carlos Villar, Yanina Sguassero, Maria Soledad Santini, Jaime Altcheh, Belkisyolé Alarcón de Noya, Sergio Sosa-Estani
Publikováno v:
Frontiers in Parasitology, Vol 2 (2023)
Trypanosoma cruzi infection is diagnosed by parasitological, molecular, and serological tests. Molecular methods based on DNA amplification provide a more sensitive alternative to classical parasitological techniques for detecting evidence of T. cruz
Externí odkaz:
https://doaj.org/article/b8bcff92341a4f9aa511d461f2c45320
Autor:
Guadalupe Romer, Leonel A Bracco, Alejandro D Ricci, Virginia Balouz, Luisa Berná, Juan C Villar, Janine M Ramsey, Melissa S Nolan, Faustino Torrico, Norival Kesper, Jaime Altcheh, Carlos Robello, Carlos A Buscaglia, Fernán Agüero
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 8, p e0011542 (2023)
BackgroundTrypanosoma cruzi, the agent of Chagas disease, displays a highly structured population, with multiple strains that can be grouped into 6-7 evolutionary lineages showing variable eco-epidemiological traits and likely also distinct disease-a
Externí odkaz:
https://doaj.org/article/579e0e5b9dd54fdb88080b19cef82008
Autor:
Rocio Rivero, Mónica Inés Esteva, Erya Huang, Leylen Colmegna, Jaime Altcheh, Ulrike Grossmann, Andrés Mariano Ruiz, CHICO and CHICO SECURE Study Groups
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 6, p e0011440 (2023)
BackgroundMeasurement of the success of antitrypanosomal treatment for Chagas disease is difficult, particularly in the chronic phase of the disease, because anti-Trypanosoma cruzi antibodies persist in serum for prolonged periods. We studied the eff
Externí odkaz:
https://doaj.org/article/9a0ee13271994761b4d8354ed12dad65
Autor:
Jaime Altcheh, Guillermo Moscatelli, Martin Caruso, Samanta Moroni, Margarita Bisio, Maria Rosa Miranda, Celia Monla, Maria Vaina, Maria Valdez, Lucrecia Moran, Teresa Ramirez, Oscar Ledesma Patiño, Adelina Riarte, Nicolas Gonzalez, Jayme Fernandes, Fabiana Alves, Isabela Ribeiro, Facundo Garcia-Bournissen
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 5, p e0010850 (2023)
BackgroundThere is a major need for information on pharmacokinetics (PK) of benznidazole (BNZ) in children with Chagas disease (CD). We conducted a multicentre population PK, safety and efficacy study in children, infants and neonates with CD treated
Externí odkaz:
https://doaj.org/article/95dc14fa93374db69b2dd62bfebaad28
Autor:
Nicolás Leonel González, Guillermo Moscatelli, Samanta Moroni, Griselda Ballering, Laura Jurado, Nicolás Falk, Andrés Bochoeyer, Alejandro Goldsman, María Grippo, Héctor Freilij, Facundo Garcia Bournissen, Eric Chatelain, Jaime Altcheh
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 12, p e0010968 (2022)
BackgroundParasite persistence after acute infection with Trypanosoma cruzi is an important factor in the development of Chagas disease (CD) cardiomyopathy. Few studies have investigated the clinical effectiveness of CD treatment through the evaluati
Externí odkaz:
https://doaj.org/article/a55c1893c5f9412f8d54693685e06af6
Autor:
Julián Ernesto Nicolás Gulin, Margarita María Catalina Bisio, Daniela Rocco, Jaime Altcheh, María Elisa Solana, Facundo García-Bournissen
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Drug repurposing and combination therapy have been proposed as cost-effective strategies to improve Chagas disease treatment. Miltefosine (MLT), a synthetic alkylphospholipid initially developed for breast cancer and repositioned for leishmaniasis, i
Externí odkaz:
https://doaj.org/article/5e0cdc32c7e14717bfa3400ac03bf18c
Autor:
Jaime Altcheh, Luis Castro, Juan C Dib, Ulrike Grossmann, Erya Huang, Guillermo Moscatelli, Jimy José Pinto Rocha, Teresa Estela Ramírez, CHICO Study Group
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008912 (2021)
Nifurtimox is a recommended treatment for Chagas disease, but data from treated children are limited. We investigated the efficacy, safety and tolerability of nifurtimox administered as divisible, dispersible 30 mg and 120 mg tablets in children with
Externí odkaz:
https://doaj.org/article/1dcc32d8cefc4129bba991b7e817b145