Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Jaime A. Valderrama"'
Autor:
Julio Benites, Jaime A. Valderrama, Álvaro Contreras, Cinthya Enríquez, Ricardo Pino-Rios, Osvaldo Yáñez, Pedro Buc Calderon
Publikováno v:
Molecules, Vol 28, Iss 11, p 4323 (2023)
A series of 2-phenylamino-3-acyl-1,4-naphtoquinones were evaluated regarding their in vitro antiproliferative activities using DU-145, MCF-7 and T24 cancer cells. Such activities were discussed in terms of molecular descriptors such as half-wave pote
Externí odkaz:
https://doaj.org/article/6d0ac64f46104f319b3147f8ab682f3a
Autor:
Vanessa Correa-Forero, Gabriel D. Pinilla-Monsalve, Jaime A. Valderrama-Chaparro, Pablo Amaya-Gonzalez
Publikováno v:
Journal of Infection and Public Health, Vol 13, Iss 1, Pp 143-148 (2020)
Cryptococcus is a cosmopolitan fungus with tropism for the nervous system and a higher prevalence of infection in immunosuppressed patients. Neurological compromise caused by this microorganism mainly debuts as a meningeal syndrome (headache, fever,
Externí odkaz:
https://doaj.org/article/eaa0426b38a34baa8b28de1293c31aad
Autor:
Jaime A. Valderrama, Andrea Pérez-Herrera, Giulio G. Muccioli, Edmundo A. Venegas-Casanova, Rafael Jara-Aguilar, Pedro Buc Calderon, Julio Benites
Publikováno v:
Journal of Chemistry, Vol 2022 (2022)
Oximes are known for their anti-inflammatory, antimicrobial, antioxidant, and anticancer activities. Frequently, modification of biologically active carbonyl compounds into oximes leads to increased activity. The present study reports the reactivity
Externí odkaz:
https://doaj.org/article/896959ef273b400cb700e199f407e506
Autor:
David Ríos, Jaime A. Valderrama, Gonzalo Quiroga, Jonathan Michea, Felipe Salas, Eduardo Álvarez Duarte, Edmundo A. Venegas-Casanova, Rafael Jara-Aguilar, Carlos Navarro-Retamal, Pedro Buc Calderon, Julio Benites
Publikováno v:
Molecules, Vol 27, Iss 9, p 3035 (2022)
The high rates of morbidity and mortality due to fungal infections are associated with a limited antifungal arsenal and the high toxicity of drugs. Therefore, the identification of novel drug targets is challenging due to the several resemblances bet
Externí odkaz:
https://doaj.org/article/a20861244a1348beaf115a8aca16e743
Autor:
Beatriz E. Muñoz, Valentina Quintana-Peña, Maria C. Gonzalez, Jaime A. Valderrama, Yor Jaggy Castaño-Pino, Domiciano Rincón, Andrés Navarro, Jorge L. Orozco
Publikováno v:
Parkinson's Disease, Vol 2020 (2020)
Introduction. Parkinson’s disease (PD) is one of the most prevalent age-related neurodegenerative disorders. The progression of PD produces an important disease burden in patients due to functional impairment, which also has repercussions on caregi
Externí odkaz:
https://doaj.org/article/63bf65f4712b442d82eb3c06387529b8
Autor:
Gissela Araya, Julio Benites, Juan S. Reyes, Andrés E. Marcoleta, Jaime A. Valderrama, Rosalba Lagos, Octavio Monasterio
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
The increasing detection of virulent and/or multidrug resistant bacterial strains makes necessary the development of new antimicrobial agents acting through novel mechanisms and cellular targets. A good choice are molecules aimed to interfere with th
Externí odkaz:
https://doaj.org/article/c185dfd41e7f40d4b18eaa395e9a82a4
Publikováno v:
Molecules, Vol 25, Iss 4, p 953 (2020)
A series of benzo[g]benzothiazolo[2,3-b]quinazoline-7,12-quinones were prepared from 2-acylnaphthohydroquinones and 2-aminobenzothiazoles and were evaluated for their in vitro antiproliferative activity. After screening using the MTT reduction assay,
Externí odkaz:
https://doaj.org/article/dc6b0c6360d54048894d547078d16a3d
Autor:
Julio Benites, Juan Meléndez, Cynthia Estela, David Ríos, Luis Espinoza, Iván Brito, Jaime A. Valderrama
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 2448-2452 (2014)
A number of N-phenyl-1,4-naphthoquinone monoimines 6–10 were prepared by on-water oxidative phenylamination of 1,5-dihydroxynaphthalene (1) and 5-acetylamino-1-hydroxynaphthalene (5) with oxygen-substituted phenylamines under aerobic conditions and
Externí odkaz:
https://doaj.org/article/28d36e64f9854df5973228791bae053d
Autor:
Juana Andrea Ibacache, Virginia Delgado, Julio Benites, Cristina Theoduloz, Verónica Arancibia, Giulio G. Muccioli, Jaime A. Valderrama
Publikováno v:
Molecules, Vol 19, Iss 1, Pp 726-739 (2014)
The synthesis of a variety of 1-aryl-7-phenylaminoisoquinolinequinones from 1,4-benzoquinone and arylaldehydes via the respective 1-arylisoquinolinequinones is reported. The cyclic voltammograms of the new compounds exhibit two one-electron reduction
Externí odkaz:
https://doaj.org/article/19dadc8dad7841f988c613c7391c9be9
Autor:
Julio Benites, Jaime A. Valderrama, Maryan Ramos, Maudy Valenzuela, Angélica Guerrero-Castilla, Giulio G. Muccioli, Pedro Buc Calderon
Publikováno v:
Molecules, Vol 24, Iss 9, p 1780 (2019)
A broad range of 3-acyl-2,5-bis(phenylamino)-1,4-benzoquinones were synthesized and their voltammetric values, as well as in vitro cancer cell cytotoxicities, were assessed. The members of this series were prepared from acylbenzoquinones and phenylam
Externí odkaz:
https://doaj.org/article/f496b3dcfb4f41288db9ab68adaa8239