Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jaigeeth Deveryshetty"'
Autor:
Jaigeeth Deveryshetty, Rahul Chadda, Jenna R. Mattice, Simrithaa Karunakaran, Michael J. Rau, Katherine Basore, Nilisha Pokhrel, Noah Englander, James A. J. Fitzpatrick, Brian Bothner, Edwin Antony
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Homologous recombination (HR) is an essential double-stranded DNA break repair pathway. In HR, Rad52 facilitates the formation of Rad51 nucleoprotein filaments on RPA-coated ssDNA. Here, we decipher how Rad52 functions using single-particle
Externí odkaz:
https://doaj.org/article/01f000207b0349d299eef6c4244d2fbc
Autor:
Sahiti Kuppa, Jaigeeth Deveryshetty, Rahul Chadda, Jenna R. Mattice, Nilisha Pokhrel, Vikas Kaushik, Angela Patterson, Nalini Dhingra, Sushil Pangeni, Marisa K. Sadauskas, Sajad Shiekh, Hamza Balci, Taekjip Ha, Xiaolan Zhao, Brian Bothner, Edwin Antony
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The single stranded DNA binding protein RPA coordinates DNA metabolism using multiple protein and DNA interaction domains. Here, the authors show that the chaperone-like protein Rtt105 staples RPA domains to prevent untimely protein interactions.
Externí odkaz:
https://doaj.org/article/e99b58d62524498db2c7354c42751eca
Autor:
Jaigeeth Deveryshetty, Thibaut Peterlini, Mikhail Ryzhikov, Nadine Brahiti, Graham Dellaire, Jean-Yves Masson, Sergey Korolev
Publikováno v:
eLife, Vol 8 (2019)
BReast Cancer Associated proteins 1 and 2 (BRCA1, −2) and Partner and Localizer of BRCA2 (PALB2) protein are tumour suppressors linked to a spectrum of malignancies, including breast cancer and Fanconi anemia. PALB2 coordinates functions of BRCA1 a
Externí odkaz:
https://doaj.org/article/b5bdbf4717294484aa45d4ae90ec90fc
Publikováno v:
Encyclopedia of Inorganic and Bioinorganic Chemistry. :1-12
Autor:
Jaigeeth Deveryshetty, Rahul Chadda, Jenna Mattice, Simrithaa Karunakaran, Michael J. Rau, Katherine Basore, Nilisha Pokhrel, Noah Englander, James A.J. Fitzpatrick, Brian Bothner, Edwin Antony
Homologous recombination (HR) is a pathway for the accurate repair of double-stranded DNA breaks, which are resected to yield single-strand DNA (ssDNA). Rad52 promotes HR by facilitating formation of Rad51 nucleoprotein filaments on ssDNA. Using sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93228499994af2205f8e05cdea0fe869
https://doi.org/10.1101/2023.02.05.527205
https://doi.org/10.1101/2023.02.05.527205
Autor:
Sahiti Kuppa, Jaigeeth Deveryshetty, Rahul Chadda, Jenna Mattice, Nilisha Pokhrel, Vikas Kaushik, Angela Patterson, Nalini Dhingra, Sushil Pangeni, Marisa K. Sadauskas, Sajad Shiekh, Hamza Balci, Taekjip Ha, Xiaolan Zhao, Brian Bothner, Edwin Antony
Replication Protein A (RPA) binds to single-stranded DNA (ssDNA) and recruits over three dozen RPA-interacting proteins (RIPs) to coordinate multiple aspects of DNA metabolism including DNA replication, repair, and recombination. Rtt105 is a molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5a74b6ec7daa2d25b925bf804c690c9
https://doi.org/10.1101/2022.02.05.479199
https://doi.org/10.1101/2022.02.05.479199
Autor:
Jaigeeth Deveryshetty, Edwin Antony
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71bc08af74c96b76228734278c18da18
https://doi.org/10.1016/b978-0-12-819460-7.00246-2
https://doi.org/10.1016/b978-0-12-819460-7.00246-2
Autor:
Brian Bothner, Faiz Ahmad, Edwin Antony, Angela Patterson, Jaigeeth Deveryshetty, Jenna Mattice, Nilisha Pokhrel
Publikováno v:
Nucleic Acids Research
Replication protein A (RPA) binds to single-stranded DNA (ssDNA) and interacts with over three dozen enzymes and serves as a recruitment hub to coordinate most DNA metabolic processes. RPA binds ssDNA utilizing multiple oligosaccharide/oligonucleotid
Publikováno v:
Biophysical Journal. 121:447a
Publikováno v:
Genes
Genes, Vol 12, Iss 2002, p 2002 (2021)
Genes; Volume 12; Issue 12; Pages: 2002
Genes, Vol 12, Iss 2002, p 2002 (2021)
Genes; Volume 12; Issue 12; Pages: 2002
The tumor suppressor protein partner and localizer of BRCA2 (PALB2) orchestrates the interactions between breast cancer susceptibility proteins 1 and 2 (BRCA1, -2) that are critical for genome stability, homologous recombination (HR) and DNA repair.