Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jaie Woodard"'
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/229123af42bf4c1a9f3c4aea0a2d5be4
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 6, Pp 1-19 (2021)
Abstract The relationship between sequence variation and phenotype is poorly understood. Here, we use metabolomic analysis to elucidate the molecular mechanism underlying the filamentous phenotype of E. coli strains that carry destabilizing mutations
Externí odkaz:
https://doaj.org/article/3c35072684ac455888157fc74b2ceb64
Autor:
Duane Moes, Elnaz Banijamali, Vahid Sheikhhassani, Barbara Scalvini, Jaie Woodard, Alireza Mashaghi
Publikováno v:
MethodsX, Vol 9, Iss , Pp 101861- (2022)
The ability to describe the topology of a folded protein conformation is critically important for functional analysis, protein engineering, and drug design. Circuit topology is a unique topological framework which is widely applicable to protein anal
Externí odkaz:
https://doaj.org/article/a68eb2ddd754409c811e792b61c960d7
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009370 (2021)
Three-dimensional structures of proteins can provide important clues into the efficacy of personalized treatment. We perform a structural analysis of variants within three inherited lysosomal storage disorders, comparing variants responsive to pharma
Externí odkaz:
https://doaj.org/article/ee74011334104e0aae5ed77ec63b1276
Publikováno v:
Frontiers in Physics, Vol 8 (2020)
The biological world is composed of folded linear molecules of bewildering topological complexity and diversity. The topology of folded biomolecules such as proteins and ribonucleic acids is often subject to change during biological processes. Despit
Externí odkaz:
https://doaj.org/article/3cc305ac476649eb84d2efbadf6afa5a
Publikováno v:
Proteins. 90(9)
The contact topology of a protein determines important aspects of the folding process. The topological measure of contact order has been shown to be predictive of the rate of folding. Circuit topology is emerging as another fundamental descriptor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381a6b322e7de72a5d0c19ef5b7f0631
https://pubmed.ncbi.nlm.nih.gov/35394672
https://pubmed.ncbi.nlm.nih.gov/35394672
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 9, p e1009370 (2021)
PLoS Computational Biology, Vol 17, Iss 9, p e1009370 (2021)
Three-dimensional structures of proteins can provide important clues into the efficacy of personalized treatment. We perform a structural analysis of variants within three inherited lysosomal storage disorders, comparing variants responsive to pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8dda5f74d340d8cc65fdcbb9bb12e89
https://doi.org/10.1101/2021.07.08.451652
https://doi.org/10.1101/2021.07.08.451652
Autor:
Eugene I. Shakhnovich, Jaie Woodard, Sanchari Bhattacharyya, Shimon Bershtein, Bharat V. Adkar
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 6, Pp n/a-n/a (2021)
Molecular Systems Biology
Molecular Systems Biology
The relationship between sequence variation and phenotype is poorly understood. Here, we use metabolomic analysis to elucidate the molecular mechanism underlying the filamentous phenotype of E. coli strains that carry destabilizing mutations in dihyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976ccee89a360e395632aa619c98cad3
https://doi.org/10.1096/fasebj.2021.35.s1.01916
https://doi.org/10.1096/fasebj.2021.35.s1.01916
Publikováno v:
J Mol Biol
Numerous human diseases are caused by mutations in genomic sequences. Since amino acid changes affect protein function through mechanisms often predictable from protein structure, the integration of structural and sequence data enables us to estimate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a89d68f0ccc07d8b6d7611c09390a13
https://europepmc.org/articles/PMC8119349/
https://europepmc.org/articles/PMC8119349/
Autor:
James Walsh, Jaie Woodard
Publikováno v:
CODEE Journal. 9:1-16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e20ee05078cefd654d565c6d6ff513ca
https://doi.org/10.5642/codee.201209.01.12
https://doi.org/10.5642/codee.201209.01.12