Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jaideep K. Malhotra"'
Autor:
Ritu Kant, Zhaoyang Hu, Jaideep K Malhotra, Trine Krogh-Madsen, David J Christini, Paul M Heerdt, Geoffrey W Abbott
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82951 (2013)
Aging increases the risk of cardiac pathologies including atrial fibrillation and can alter myocardial responsiveness to therapeutic agents. Here, seeking molecular correlates of myocardial aging processes, we performed global "whole transcript" anal
Externí odkaz:
https://doaj.org/article/f402597591de49fbb3bba7b484b83cbb
Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man
Autor:
John J. Savarese, Peter M. Savard, Paul M. Heerdt, Jaideep K. Malhotra, Hiroshi Sunaga, Deena Godfrey, Joel S. Owen, Matthew T. Murrell, Michelle Steinkamp, Cynthia A. Lien
Publikováno v:
Anesthesiology. 125:1136-1143
BackgroundCW002 is a benzylisoquinolinium nondepolarizing neuromuscular-blocking drug found to be inactivated by cysteine in preclinical studies. The current study represents a dose escalation clinical trial designed to describe CW002 potency, durati
Autor:
Hiroshi Sunaga, John J. Savarese, Erin Jeannotte, Gilbert W. Carnathan, Paul M. Heerdt, Scott G. Van Ornum, Jaideep K. Malhotra, Matthew T. Murrell, Bryce J. Petty, Jeff D. McGilvra, Erica Allen, Peter M. Savard, Matthew R. Belmont
Publikováno v:
Anesthesiology. 125:732-743
Background CW002, a novel nondepolarizing neuromuscular blocking agent of intermediate duration, is degraded in vitro by l-cysteine; CW002-induced neuromuscular blockade (NMB) is antagonized in vivo by exogenous l-cysteine.1 Further, Institutional An
Publikováno v:
Anesthesiology. 112:900-909
Background CW002 is a neuromuscular blocking drug that is inactivated by endogenous L-cysteine. This study determined the exogenous L-cysteine dose-response relationship for CW002 reversal along with acute cardiovascular effects and organ toxicity in
Autor:
Ritu Kant, Zhaoyang Hu, Jaideep K Malhotra, Trine Krogh-Madsen, David J Christini, Paul M Heerdt, Geoffrey W Abbott
Publikováno v:
Circulation Research. 113
Aging-associated changes in the heart contribute to a wide variety of cardiovascular diseases. The aging atrium becomes increasingly more susceptible to development of atrial fibrillation, and even its pharmacological response to therapeutic drugs al
Autor:
Paul M. Heerdt, Geoffrey W. Abbott, Jaideep K. Malhotra, Vikram A. Kanda, David J. Christini, Zhaoyang Hu, Ritu Kant
Lone atrial fibrillation (AF) is associated with various ion channel gene sequence variants, notably the common S38G loss-of-function polymorphism in the KCNE1 K+ channel ancillary subunit gene. New-onset postoperative AF (POAF) generally occurs 48
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e669105790f6aedec14b716c33b660ee
https://europepmc.org/articles/PMC3418454/
https://europepmc.org/articles/PMC3418454/
Publikováno v:
Anesthesiology. 112(4)
CW002 is a neuromuscular blocking drug that is inactivated by endogenous L-cysteine. This study determined the exogenous L-cysteine dose-response relationship for CW002 reversal along with acute cardiovascular effects and organ toxicity in dogs.Six d
Publikováno v:
Anesthesiology. 112(4)
Background CW002 is a novel neuromuscular blocking drug with a duration dependent on the rate of cysteine adduction to the molecule. The current study characterized the pharmacodynamics and cardiopulmonary side effects of CW002 in dogs. Methods In ei
Autor:
Zhaoyang Hu, Paul M. Heerdt, Ritu Kant, Jaideep K. Malhotra, Geoffrey W. Abbott, David J. Christini, Trine Krogh-Madsen
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82951 (2013)
Kant, R; Hu, Z; Malhotra, JK; Krogh-Madsen, T; Christini, DJ; Heerdt, PM; et al.(2013). NHE isoform switching and KChIP2 upregulation in aging porcine atria. PLoS ONE, 8(12). doi: 10.1371/journal.pone.0082951. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2c68m0c8
PLoS ONE
Kant, R; Hu, Z; Malhotra, JK; Krogh-Madsen, T; Christini, DJ; Heerdt, PM; et al.(2013). NHE isoform switching and KChIP2 upregulation in aging porcine atria. PLoS ONE, 8(12). doi: 10.1371/journal.pone.0082951. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2c68m0c8
PLoS ONE
Aging increases the risk of cardiac pathologies including atrial fibrillation and can alter myocardial responsiveness to therapeutic agents. Here, seeking molecular correlates of myocardial aging processes, we performed global "whole transcript" anal