Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Jai Woong Seo"'
Autor:
Jai Woong Seo, Elizabeth S. Ingham, Lisa Mahakian, Spencer Tumbale, Bo Wu, Sadaf Aghevlian, Shahin Shams, Mo Baikoghli, Poorva Jain, Xiaozhe Ding, Nick Goeden, Tatyana Dobreva, Nicholas C. Flytzanis, Michael Chavez, Kratika Singhal, Ryan Leib, Michelle L. James, David J. Segal, R. Holland Cheng, Eduardo A. Silva, Viviana Gradinaru, Katherine W. Ferrara
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Adeno-associated viruses (AAVs) can be targeted in a tissue-specific manner, but their tissue accumulation cannot be assessed in a non-invasive manner. Here the authors conjugate a multivalent chelator labelled with Cu-64 to the surface of AAVs and i
Externí odkaz:
https://doaj.org/article/3bffb0cc262e4293b560a67f7e3c6fd9
Autor:
Katherine W. Ferrara, Anna M. Wu, Alexander D. Borowsky, Felix B. Salazar, Elizabeth S. Ingham, Sarah Tam, Matthew T. Silvestrini, Lisa M. Mahakian, Richard Tavaré, Jai Woong Seo
Supplementary Figures and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00514919634ec8bdc6b9eeef05f53699
https://doi.org/10.1158/1078-0432.22475835.v1
https://doi.org/10.1158/1078-0432.22475835.v1
Autor:
Katherine W. Ferrara, Anna M. Wu, Alexander D. Borowsky, Felix B. Salazar, Elizabeth S. Ingham, Sarah Tam, Matthew T. Silvestrini, Lisa M. Mahakian, Richard Tavaré, Jai Woong Seo
Purpose: Noninvasive and quantitative tracking of CD8+ T cells by PET has emerged as a potential technique to gauge response to immunotherapy. We apply an anti-CD8 cys-diabody, labeled with 64Cu, to assess the sensitivity of PET imaging of normal and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ce534925736e27057805a5dfcd2bfd
https://doi.org/10.1158/1078-0432.c.6529188.v1
https://doi.org/10.1158/1078-0432.c.6529188.v1
Autor:
Katherine W. Ferrara, Rolf K. Reed, Fitz-Roy Curry, Elizabeth S. Ingham, Julie Beegle, Lisa M. Mahakian, Robert D. Cardiff, Jai Woong Seo, Yueh-Chen Lin, Dustin E. Kruse, Shengping Qin, Chun-Yen Lai, Katherine D. Watson
PDF file - 137K, Detailed relationship between the PAP parameter derived through the image-guided model with the classical parameters of solute transport coefficient, clearance, and 30 minute albumin clearance (Cl30).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa726c16dad20ce65a4f8070483de88f
https://doi.org/10.1158/0008-5472.22395672.v1
https://doi.org/10.1158/0008-5472.22395672.v1
Autor:
Katherine W. Ferrara, Rolf K. Reed, Fitz-Roy Curry, Elizabeth S. Ingham, Julie Beegle, Lisa M. Mahakian, Robert D. Cardiff, Jai Woong Seo, Yueh-Chen Lin, Dustin E. Kruse, Shengping Qin, Chun-Yen Lai, Katherine D. Watson
PDF file - 51K, Representative biodistribution of tissues 48 hours after nanoparticle injection (N=8). Accumulation was significantly greater for insonified tumors (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8915b300c46299932ec58bda66c4339d
https://doi.org/10.1158/0008-5472.22395675.v1
https://doi.org/10.1158/0008-5472.22395675.v1
Autor:
Jai Woong Seo, Javier Ajenjo, Bo Wu, Elise Robinson, Marina Nura Raie, James Wang, Spencer K. Tumbale, Pablo Buccino, David Alexander Anders, Bin Shen, Frezghi G. Habte, Corinne Beinat, Michelle L. James, Samantha Taylor Reyes, Sripriya Ravindra Kumar, Timothy F. Miles, Jason T. Lee, Viviana Gradinaru, Katherine W. Ferrara
Publikováno v:
Biomaterials. 288
The development of gene delivery vehicles with high organ specificity when administered systemically is a critical goal for gene therapy. We combine optical and positron emission tomography (PET) imaging of 1) reporter genes and 2) capsid tags to ass
Autor:
Poorva Jain, Eduardo A. Silva, Spencer K. Tumbale, Michelle L. James, Ryan D. Leib, Katherine W. Ferrara, Mo Baikoghli, Jai Woong Seo, Tatyana Dobreva, Michael Chavez, Bo Wu, David J. Segal, Nick Goeden, R. Holland Cheng, Lisa M. Mahakian, Kratika Singhal, Nicholas C. Flytzanis, Shahin Shams, Xiaozhe Ding, Elizabeth S. Ingham, Sadaf Aghevlian, Viviana Gradinaru
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Adeno-associated viruses (AAVs) are typically single-stranded deoxyribonucleic acid (ssDNA) encapsulated within 25-nm protein capsids. Recently, tissue-specific AAV capsids (e.g. PHP.eB) have been shown to enhance brain delivery in rodents via the LY
Autor:
Bo Wu, Aris J Kare, Marina Nura Raie, Spencer K. Tumbale, Katherine W. Ferrara, Sadaf Aghevlian, Jai Woong Seo
Publikováno v:
Nucl Med Biol
BACKGROUND: A novel [(64)Cu]Cu-NOTA-aCD40 immunoPET tracer was developed to image a CD40(+) pancreatic tumor model in C57BL/6 mice and to study the biodistribution profile of the agonist CD40 (aCD40) monoclonal antibody (mAb) alone or combined with o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1b389417f290dfb04d55ec942f11b7
https://europepmc.org/articles/PMC8486004/
https://europepmc.org/articles/PMC8486004/
Autor:
Sarah Tam, Lisa M. Mahakian, Alexander D. Borowsky, Elizabeth S. Ingham, Katherine W. Ferrara, Anna M. Wu, Matthew T. Silvestrini, Jai Woong Seo, Richard Tavaré, Felix B. Salazar
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 24, iss 20
Purpose: Noninvasive and quantitative tracking of CD8+ T cells by PET has emerged as a potential technique to gauge response to immunotherapy. We apply an anti-CD8 cys-diabody, labeled with 64Cu, to assess the sensitivity of PET imaging of normal and
Autor:
Katherine W. Ferrara, Jai Woong Seo, Sarah Tam, Josquin Foiret, Hua Zhang, Hamilton Kakwere, Lisa M. Mahakian
Publikováno v:
2019 IEEE International Ultrasonics Symposium (IUS).
Focused ultrasound (FUS) to open the blood brain barrier (BBB) is under evaluation for the delivery of therapeutic agents to the brain. Regarding delivery of genes through the BBB, adeno-associated viruses (AAVs) have generated interest due to their