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Akademický článek

A pattern of early radiation-induced inflammatory cytokine expression is associated with lung toxicity in patients with non-small cell lung cancer.

Autor: Shankar Siva, Michael MacManus, Tomas Kron, Nickala Best, Jai Smith, Pavel Lobachevsky, David Ball, Olga Martin

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109560 (2014)

Lung inflammation leading to pulmonary toxicity after radiotherapy (RT) can occur in patients with non-small cell lung cancer (NSCLC). We investigated the kinetics of RT induced plasma inflammatory cytokines in these patients in order to identify cli

Externí odkaz: https://doaj.org/article/7a2521258cca45d98ec9a75536801c6d

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Supplementary Figure 2 from Radiotherapy for Non–Small Cell Lung Cancer Induces DNA Damage Response in Both Irradiated and Out-of-field Normal Tissues

Autor: Olga A. Martin, David Ball, Jai Smith, Nickala Best, Jessica Ventura, Richard J. Lobb, Andreas Möller, Tomas Kron, Michael P. MacManus, Pavel Lobachevsky, Shankar Siva

Mean (+/- SD) Changes in concentration of plasma cytokine levels at baseline, 1-hour, 24-hours and 4-weeks after commencement of RT stratified by use of concurrent chemotherapy. Change at 1-hour in MDC and 4 weeks in MIP-1α is marked with an asteris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f5f1a2e78f5a2bf381e4c1e4e9952d
https://doi.org/10.1158/1078-0432.22468769.v1

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Data from Radiotherapy for Non–Small Cell Lung Cancer Induces DNA Damage Response in Both Irradiated and Out-of-field Normal Tissues

Autor: Olga A. Martin, David Ball, Jai Smith, Nickala Best, Jessica Ventura, Richard J. Lobb, Andreas Möller, Tomas Kron, Michael P. MacManus, Pavel Lobachevsky, Shankar Siva

Purpose: To study the response of irradiated and out-of-field normal tissues during localized curative intent radiotherapy.Experimental Design: Sixteen patients with non–small cell lung carcinoma (NSCLC) received 60 Gy in 30 fractions of definitive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f06bfcb106853712a78266fdaaf3e1
https://doi.org/10.1158/1078-0432.c.6527048

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Laminin 521 enhances self-renewal via STAT3 activation and promotes tumor progression in colorectal cancer

Autor: Alexander G. Heriot, Laura M. Beyit, Sophie Paquet-Fifield, Benjamin N. J. Thomson, Corina Behrenbruch, Yuan Cao, Jai Smith, Frédéric Hollande, Yan Qin, Carolyn Shembrey

Publikováno v: Cancer Letters. 476:161-169

Remodeling of basement membrane proteins contributes to tumor progression towards the metastatic stage. One of these proteins, laminin 521 (LN521), sustains embryonic and induced pluripotent stem cell self-renewal, but its putative role in cancer is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f564fc3dd2c8a25e0b9c819dc25d9470
https://doi.org/10.1016/j.canlet.2020.02.026

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Longitudinal Monitoring of Intra-Tumoural Heterogeneity Using Optical Barcoding of Patient-Derived Colorectal Tumour Models

Autor: Carolyn Shembrey, Jai Smith, Mélodie Grandin, Nathalia Williams, Hyun-Jung Cho, Christina Mølck, Corina Behrenbruch, Benjamin NJ. Thomson, Alexander G. Heriot, Delphine Merino, Frédéric Hollande

Publikováno v: Cancers; Volume 14; Issue 3; Pages: 581
Cancers, Vol 14, Iss 581, p 581 (2022)

Geno- and phenotypic heterogeneity amongst cancer cell subpopulations are established drivers of treatment resistance and tumour recurrence. However, due to the technical difficulty associated with studying such intra-tumoural heterogeneity, this phe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0efdd395eb62a90168b9ae6cbe492b0
https://pubmed.ncbi.nlm.nih.gov/35158849

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CD44v6 Defines a New Population of Circulating Tumor Cells Not Expressing EpCAM

Publikováno v: Cancers
Cancers, MDPI, 2021, 13 (19), pp.4966. ⟨10.3390/cancers13194966⟩
Cancers; Volume 13; Issue 19; Pages: 4966
Cancers, 2021, 13 (19), pp.4966. ⟨10.3390/cancers13194966⟩
Cancers, Vol 13, Iss 4966, p 4966 (2021)
Cancers, 13 (19)

Simple Summary In the present work, we describe (for the first time) the use of the transmembrane protein, CD44v6, to detect CTCs from blood samples of several patients with colorectal or breast cancer. We used CD44v6 antibodies to demonstrate that l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c514241b09c42e5dc62f4a86bbc1eb5
https://hal.archives-ouvertes.fr/hal-03394453/document

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