Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Jai Moo Shin"'
Publikováno v:
Molecules, Vol 14, Iss 12, Pp 5247-5280 (2009)
New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
Externí odkaz:
https://doaj.org/article/c18a37f4c6b648fe8db80fd42c640d25
Autor:
Jai Moo Shin1 jaishin@ucla.edu, Wallmark, Björn2 bjoern.wallmark@schering.de, Sachs, George1 gsachs@ucla.edu
Publikováno v:
Encyclopedic Reference of Molecular Pharmacology. 2004, p771-774. 4p.
Autor:
Jai Moo Shin1 jaimooshin@gmail.com, Nayoung Kim2,3
Publikováno v:
Journal of Neurogastroenterology & Motility. Jan2013, Vol. 19 Issue 1, p25-35. 11p.
Autor:
Jai Moo Shin1, Sachs, George1, Young-moon Cho1 ymkscho@yahoo.com, Garst, Michael2 garstmichael@allergan.com
Publikováno v:
Molecules. Dec2009, Vol. 14 Issue 12, p5247-5280. 34p. 6 Diagrams, 1 Chart.
Autor:
Nayoung Kim, Jai Moo Shin
Publikováno v:
Journal of Neurogastroenterology and Motility
Proton pump inhibitor (PPI) is a prodrug which is activated by acid. Activated PPI binds covalently to the gastric H(+), K(+)-ATPase via disulfide bond. Cys813 is the primary site responsible for the inhibition of acid pump enzyme, where PPIs bind. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9d7c2c56d895df0e3663a16a01e82b
https://doi.org/10.5056/jnm.2013.19.1.25
https://doi.org/10.5056/jnm.2013.19.1.25
Publikováno v:
Current Gastroenterology Reports
Sachs, George; Shin, Jai Moo; & Hunt, Richard. (2010). Novel Approaches to Inhibition of Gastric Acid Secretion. Current Gastroenterology Reports, 12(6), pp 437-447. doi: 10.1007/s11894-010-0149-5. Retrieved from: http://www.escholarship.org/uc/item/6319s54m
Sachs, George; Shin, Jai Moo; & Hunt, Richard. (2010). Novel Approaches to Inhibition of Gastric Acid Secretion. Current Gastroenterology Reports, 12(6), pp 437-447. doi: 10.1007/s11894-010-0149-5. Retrieved from: http://www.escholarship.org/uc/item/6319s54m
The gastric H,K-adenosine triphosphatase (ATPase) is the primary target for treatment of acid-related diseases. Proton pump inhibitors (PPIs) are weak bases composed of two moieties, a substituted pyridine with a primary pK(a) of about 4.0 that allow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cafb48f296add93f9ecc474ba3e8e7b
http://europepmc.org/articles/PMC2974194
http://europepmc.org/articles/PMC2974194
Autor:
George Sachs, Jai Moo Shin
Publikováno v:
Current Gastroenterology Reports. 10:528-534
The gastric H,K-ATPase is the primary target for the treatment of acid-related diseases. Proton pump inhibitors (PPIs) are weak bases composed of two moieties, a substituted pyridine with a primary pK(a) of about 4.0, which allows selective accumulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedafab7eca702badd22b7c0513133fa
https://doi.org/10.1007/s11894-008-0098-4
https://doi.org/10.1007/s11894-008-0098-4
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 457:609-622
The gastric H,K-ATPase, a member of the P(2)-type ATPase family, is the integral membrane protein responsible for gastric acid secretion. It is an alpha,beta-heterodimeric enzyme that exchanges cytoplasmic hydronium with extracellular potassium. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c811eb00475652a20dd8f9439b955c
https://doi.org/10.1007/s00424-008-0495-4
https://doi.org/10.1007/s00424-008-0495-4
Publikováno v:
Cellular and Molecular Life Sciences. 65:264-281
Inhibition of gastric acid secretion is the mainstay of the treatment of gastroesophageal reflux disease and peptic ulceration; therapies to inhibit acid are among the best-selling drugs worldwide. Highly effective agents targeting the histamine H2 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ee165c51dfa52e225d4ad01e542110
https://doi.org/10.1007/s00018-007-7249-x
https://doi.org/10.1007/s00018-007-7249-x
Publikováno v:
Biochemistry. 44:16321-16332
Cross-linking and two-dimensional crystallization studies have suggested that the membrane-bound gastric H,K-ATPase might be a dimeric alpha,beta-heterodimer. Effects of an oligomeric structure on the characteristics of E(1), E(2), and phosphoenzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e90a3e808d6bad6ec05f690ce72fdf5
https://doi.org/10.1021/bi051342q
https://doi.org/10.1021/bi051342q