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Akademický článek

Lysogeny with Shiga toxin 2-encoding bacteriophages represses type III secretion in enterohemorrhagic Escherichia coli.

Autor: Xuefang Xu, Sean P McAteer, Jai J Tree, Darren J Shaw, Eliza B K Wolfson, Scott A Beatson, Andrew J Roe, Lesley J Allison, Margo E Chase-Topping, Arvind Mahajan, Rosangela Tozzoli, Mark E J Woolhouse, Stefano Morabito, David L Gally

Publikováno v: PLoS Pathogens, Vol 8, Iss 5, p e1002672 (2012)

Lytic or lysogenic infections by bacteriophages drive the evolution of enteric bacteria. Enterohemorrhagic Escherichia coli (EHEC) have recently emerged as a significant zoonotic infection of humans with the main serotypes carried by ruminants. Typic

Externí odkaz: https://doaj.org/article/877ebce2260d415c93f399dd32115a1d

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Akademický článek

Screening of an E. coli O157:H7 bacterial artificial chromosome library by comparative genomic hybridisation to identify genomic regions contributing to growth in bovine gastrointestinal mucus and epithelial cell colonizationn

Autor: Jianing eBai, Sean P McAteer, Edith ePaxton, Arvind eMahajan, David eGally, Jai J Tree

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 2 (2011)

Enterohemorrhagic E. coli (EHEC) O157:H7 can cause serious gastrointestinal and systemic disease in humans following direct or indirect exposure to the bacterium excreted in ruminant feces. The main colonization site of EHEC O157:H7 in cattle is the

Externí odkaz: https://doaj.org/article/cf2fa37afd0e4e2da978f5583f453685

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Akademický článek

The 3′ UTR of vigR is required for virulence in Staphylococcus aureus and has expanded through STAR sequence repeat insertions

Autor: Daniel G. Mediati, William Dan, David Lalaouna, Hue Dinh, Alaska Pokhrel, Keiran N. Rowell, Katharine A. Michie, Timothy P. Stinear, Amy K. Cain, Jai J. Tree

Publikováno v: Cell Reports, Vol 43, Iss 4, Pp 114082- (2024)

Summary: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are alarmingly common, and treatment is confined to last-line antibiotics. Vancomycin is the treatment of choice for MRSA bacteremia, and treatment failure is often asso

Externí odkaz: https://doaj.org/article/9b2458159bc54422ad6aaf0e9f9cde95

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Akademický článek

Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

A variant of group A Streptococcus serotype M1 (UK) has been increasingly reported and can be differentiated from the global variant by its overexpression of the superantigen SpeA. Here, Davies et al probe the mechanism behind enhanced SpeA expressio

Externí odkaz: https://doaj.org/article/c8e8696ec17643b4a4f2990cdf959bbe

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Akademický článek

RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression

Autor: Stuart W. McKellar, Ivayla Ivanova, Pedro Arede, Rachel L. Zapf, Noémie Mercier, Liang-Cui Chu, Daniel G. Mediati, Amy C. Pickering, Paul Briaud, Robert G. Foster, Grzegorz Kudla, J. Ross Fitzgerald, Isabelle Caldelari, Ronan K. Carroll, Jai J. Tree, Sander Granneman

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Regulatory small RNA (sRNA) interact with mRNAs to regulate their stability, transcription, and translation via diverse mechanisms. Here, McKellar et al. apply RNase IIICLASH of multi-drug resistant Staphylococcus aureus under different culture condi

Externí odkaz: https://doaj.org/article/5c83133778664f04bc823f94397e141e

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Akademický článek

RNase III-CLASH of multi-drug resistant Staphylococcus aureus reveals a regulatory mRNA 3′UTR required for intermediate vancomycin resistance

Autor: Daniel G. Mediati, Julia L. Wong, Wei Gao, Stuart McKellar, Chi Nam Ignatius Pang, Sylvania Wu, Winton Wu, Brandon Sy, Ian R. Monk, Joanna M. Biazik, Marc R. Wilkins, Benjamin P. Howden, Timothy P. Stinear, Sander Granneman, Jai J. Tree

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Regulatory small RNA (sRNA) interact with mRNAs to regulate their stability, transcription, and translation via diverse mechanisms. Here, Mediati et al. apply RNase III-CLASH to multidrug-resistant Staphylococcus aureus to characterise the network of

Externí odkaz: https://doaj.org/article/d679ff7794784a6c999945fa7bd9395e

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Akademický článek

The Small RNA CyaR Activates Translation of the Outer Membrane Haem Receptor chuA in Enterohemorrhagic Escherichia coli

Autor: Brandon M. Sy, Jai J. Tree

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

To sense the transition from environment to host, bacteria use a range of environmental cues to control expression of virulence genes. Iron is tightly sequestered in host tissues and in the human pathogen enterohemorrhagic Escherichia coli (EHEC) iro

Externí odkaz: https://doaj.org/article/16336031449e46ef88aee1dbdb28859f

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Akademický článek

Publisher Correction: RNase III-CLASH of multi-drug resistant Staphylococcus aureus reveals a regulatory mRNA 3′UTR required for intermediate vancomycin resistance

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)

Externí odkaz: https://doaj.org/article/54fa913078284d69af4dba8037a9a965

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Akademický článek

Small RNA Regulation of Virulence in Pathogenic Escherichia coli

Autor: Brandon M. Sy, Jai J. Tree

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)

Enteric and extraintestinal pathotypes of Escherichia coli utilize a wide range of virulence factors to colonize niches within the human body. During infection, virulence factors such as adhesins, secretions systems, or toxins require precise regulat

Externí odkaz: https://doaj.org/article/958fc8d65d2a4dc8aacf8bd2b063d1a6

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