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of 37
pro vyhledávání: '"Jai A. Pathak"'
Autor:
Jai A. Pathak, Sean Nugent, Michael F. Bender, Christopher J. Roberts, Robin J. Curtis, Jack F. Douglas
Publikováno v:
Polymers, Vol 13, Iss 4, p 601 (2021)
The Huggins coefficient kH is a well-known metric for quantifying the increase in solution viscosity arising from intermolecular interactions in relatively dilute macromolecular solutions, and there has been much interest in this solution property in
Externí odkaz:
https://doaj.org/article/fa0f28cefbd24079a3b8d64e883e93a2
Autor:
Jack F. Douglas, Sean Nugent, Jai A. Pathak, Robin J. Curtis, Christopher J. Roberts, Michael F. Bender
Publikováno v:
Polymers, Vol 13, Iss 601, p 601 (2021)
Polymers
Volume 13
Issue 4
Polymers
Volume 13
Issue 4
The Huggins coefficient kH is a well-known metric for quantifying the increase in solution viscosity arising from intermolecular interactions in relatively dilute macromolecular solutions, and there has been much interest in this solution property in
Autor:
Gary G. Adams, Stephen E. Harding, Prakash Manikwar, Tabot M. D. Besong, Maria Monica Castellanos, Prasad Sarangapani, Justin Weaver, Jai A. Pathak, Steven M. Bishop, Arun Parupudi
Publikováno v:
Journal of Pharmaceutical Sciences. 105:3496-3506
The role of antibody structure (conformation) in solution rheology is probed. It is demonstrated here that pH-dependent changes in the tertiary structure of 2 mAb solutions lead to viscoelasticity and not merely a shear viscosity (η) increase. Stead
Autor:
Christopher F. van der Walle, Clair Baldock, Shahid Uddin, Daniel Corbett, Peng Ke, Jai A. Pathak, Robin Curtis, Carlos Avendaño, Rose Keeling, Sofia Ekizoglou, Prasad Sarangapani, Max Hebditch
Publikováno v:
The journal of physical chemistry. B. 121(35)
Predicting the concentrated solution behavior for monoclonal antibodies requires developing and using minimal models to describe their shape and interaction potential. Toward this end, the small-angle X-ray scattering (SAXS) profiles for a monoclonal
Publikováno v:
Current Opinion in Colloid & Interface Science. 19(5):438-449
In this review, we attempt to give a concise overview of recent progress made in mechanistic understanding of protein aggregation, particulate formation and protein solution rheology. Recent advances in analytical techniques and methods for character
Publikováno v:
Biophysical Journal. 104(4):913-923
Protein solution rheology data in the biophysics literature have incompletely identified factors that govern hydrodynamics. Whereas spontaneous protein adsorption at the air/water (A/W) interface increases the apparent viscosity of surfactant-free gl
Interfacial dilatational deformation accelerates particle formation in monoclonal antibody solutions
Autor:
Gigi L. Lin, Valeria Riguero, Yoen Joo Kim, Jai A. Pathak, Marcia Carlson, Gerald G. Fuller, Jean S. Buff, Dong Hyun Kim
Publikováno v:
Soft matter. 12(14)
Protein molecules are amphiphilic moieties that spontaneously adsorb at the air/solution (A/S) interface to lower the surface energy. Previous studies have shown that hydrodynamic disruptions to these A/S interfaces can result in the formation of pro
Autor:
Jai A. Pathak, Robin Curtis, Jack F. Douglas, Prasad Sarangapani, Steven D. Hudson, Ronald L. Jones
Publikováno v:
Biophysical Journal. 113:753-754
Autor:
Hyojoon Lee, Franck Snijkers, Paul Kim, Anastasia Nikopoulou, Dimitris Vlassopoulos, Evelyne Van Ruymbeke, Jai A. Pathak, Taihyun Chang, Nilos Hadjichristidis
Publikováno v:
Macromolecules. 44:8631-8643
We combine state-of-the-art synthetic, chromatographic, rheological, and modeling techniques in order to address the role of architectural polydispersity in the rheology of model branched polymers. This synergy is shown to be imperative in the field
Publikováno v:
The Journal of Physical Chemistry B. 113:8820-8827
Phase separation kinetics of polyethylene copolymer blends polyethylene-co-hexene (PEH)/polyethylene-co-butene (PEB) at a phase separation temperature of 130 degrees C have been investigated through the combination of rheological measurements and opt