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pro vyhledávání: '"Jahminy Sasikaran"'
Publikováno v:
Applied and environmental microbiology. 81(16)
Pseudomonas aeruginosa , Yersinia pestis , and many other bacteria are able to utilize the C 5 -dicarboxylic acid itaconate (methylenesuccinate). Itaconate degradation starts with its activation to itaconyl coenzyme A (itaconyl-CoA), which is further
Publikováno v:
Nature chemical biology. 10(5)
Itaconate (methylenesuccinate) was recently identified as a mammalian metabolite whose production is substantially induced during macrophage activation. This compound is a potent inhibitor of isocitrate lyase, a key enzyme of the glyoxylate cycle, wh