Impact of the Metal Center and Leaving Group on the Anticancer Activity of Organometallic Complexes of Pyridine-2-carbothioamide

Autor: Jahanzaib Arshad, Kelvin K. H. Tong, Sanam Movassaghi, Tilo Söhnel, Stephen M. F. Jamieson, Muhammad Hanif, Christian G. Hartinger

Publikováno v: Molecules, Vol 26, Iss 4, p 833 (2021)

RuII(cym)Cl (cym = η6-p-cymene) complexes of pyridinecarbothioamides have shown potential for development as orally active anticancer metallodrugs, underlined by their high selectivity towards plectin as the molecular target. In order to investigate

Externí odkaz: https://doaj.org/article/0c29b966a1e74fa9bb1d5c7c6222e631

A Multitargeted Approach: Organorhodium Anticancer Agent Based on Vorinostat as a Potent Histone Deacetylase Inhibitor

Autor: Stephen M. F. Jamieson, Rhonda J. Rosengren, Kamal Patel, Muhammad Hanif, Jahanzaib Arshad, Jonathan W. Astin, Sanam Movassaghi, Christian G. Hartinger, Euphemia Leung, Ayesha Zafar, Tilo Söhnel, Vijayalekshmi Sarojini, Zohaib Rana, Jóhannes Reynisson

Publikováno v: Angewandte Chemie (International ed. in English). 59(34)

The combination of more than one bioactive moiety in a multitargeted anticancer agent may result in synergistic activity of its components. Using this concept, bioorganometallic compounds were designed to feature a metal center, a 2-pyridinecarbothio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f527635805144be1342c6954fac86dd
https://pubmed.ncbi.nlm.nih.gov/32431061

Anticancer Ru(η6-p-cymene) complexes of 2-pyridinecarbothioamides: A structure–activity relationship study

Autor: Muhammad Hanif, Christian G. Hartinger, Amir Waseem, Sanam Movassaghi, Stephen M. F. Jamieson, Jahanzaib Arshad, Tilo Söhnel, Mario Kubanik

Publikováno v: Journal of Inorganic Biochemistry. 177:395-401

Ru(II) and Os(II) complexes of 2-pyridinecarbothioamide ligands were introduced as orally administrable anticancer agents (S.M. Meier, M. Hanif, Z. Adhireksan, V. Pichler, M. Novak, E. Jirkovsky, M.A. Jakupec, V.B. Arion, C.A. Davey, B.K. Keppler, C.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::070a36a586d6ee4df3e40ca68a12dcb1
https://doi.org/10.1016/j.jinorgbio.2017.08.034

SYNTHESIS, CHARACTERIZATION AND UREASE INHIBITION STUDIES OF TRANSITION METAL COMPLEXES OF THIOUREAS BEARING IBUPROFEN MOIETY

Autor: Aamer Saeed, Jahanzaib Arshad, Muhammad Azhar Hyat Nawaz, Amara Mumtaz, Jamshed Iqbal

Publikováno v: Journal of the Chilean Chemical Society v.63 n.2 2018
SciELO Chile
CONICYT Chile
instacron:CONICYT
Journal of the Chilean Chemical Society, Volume: 63, Issue: 2, Pages: 3934-3940, Published: JUN 2018

Starting from ibuprofen, a non-steroidal anti-inflammatory drug, N,N’-disubstituted thiourea derivatives were synthesized by refluxing the acid chloride of ibuprofen with potassium thiocyanate followed by substituted anilines to get N-2-(4-(2-methy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f72e6cf394173566e46e7dc44419bd
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000203934

Pollution Status of Pakistan: A Retrospective Review on Heavy Metal Contamination of Water, Soil, and Vegetables

Autor: Jahanzaib Arshad, Zahid Mehmood, Ghulam Murtaza, Ashif Sajjad, Amir Waseem, Farhat Iqbal

Publikováno v: BioMed Research International, Vol 2014 (2014)
BioMed Research International

Trace heavy metals, such as arsenic, cadmium, lead, chromium, nickel, and mercury, are important environmental pollutants, particularly in areas with high anthropogenic pressure. In addition to these metals, copper, manganese, iron, and zinc are also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebc22f9c67176f527c75501edcd22f3
https://doaj.org/article/89f04251e87a492c8fb0eccf6d33d45e