Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Jahangir Iqbal"'
Autor:
Abeer Al Otaibi, Sindiyan Al Shaikh Mubarak, Fatimah Al Hejji, Abdulrahman Almasaud, Haya Al Jami, Jahangir Iqbal, Ali Al Qarni, Naif Khalaf Al Harbi, Ahmed Bakillah
Publikováno v:
Cells, Vol 13, Iss 9, p 769 (2024)
Background: SARS-Co-V2 infection can induce ER stress-associated activation of unfolded protein response (UPR) in host cells, which may contribute to the pathogenesis of COVID-19. To understand the complex interplay between SARS-Co-V2 infection and U
Externí odkaz:
https://doaj.org/article/588e3626eb9348808a2818b3dfab88e4
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 26, Iss 5, Pp 11-21 (2021)
Intestinal and hepatic lipid metabolism plays an essential role in regulating plasma lipid levels. These lipids are mobilized on apolipoprotein B (apoB)-containing lipoproteins and their plasma homeostasis is maintained by balancing production and ca
Externí odkaz:
https://doaj.org/article/000ff210f4d64ed6afa76de75b5d2d7d
Autor:
Saeed Al Mahri, Meshail Okla, Mamoon Rashid, Shuja Shafi Malik, Jahangir Iqbal, Maria Al Ibrahim, Ghida Dairi, Amer Mahmood, Manikandan Muthurangan, Ahmed Yaqinuddin, Sameer Mohammad
Publikováno v:
Cells, Vol 12, Iss 3, p 377 (2023)
G protein-coupled receptors (GPCRs) are expressed essentially on all cells, facilitating cellular responses to external stimuli, and are involved in nearly every biological process. Several members of this family play significant roles in the regulat
Externí odkaz:
https://doaj.org/article/e108a6c7d6e3411194c48a4258fc902a
Autor:
Jahangir Iqbal, Meghan T. Walsh, Samar M. Hammad, Marina Cuchel, Daniel J. Rader, M. Mahmood Hussain
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 11, Pp 2084-2097 (2018)
Sphingolipids, including ceramide, SM, and hexosylceramide (HxCer), are carried in the plasma by lipoproteins. They are possible markers of metabolic diseases, but little is known about their control. We previously showed that microsomal triglyceride
Externí odkaz:
https://doaj.org/article/5818443b1bee48fa9d3b8d0c2041e3b0
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 1, Pp 144-154 (2018)
High plasma cholesterol levels are found in several metabolic disorders and their reductions are advocated to reduce the risk of atherosclerosis. A way to lower plasma lipids is to curtail lipoprotein production; however, this is associated with stea
Externí odkaz:
https://doaj.org/article/9e0da40156ef4060bf4b635e9a895317
Autor:
Ying Liu, Donna M. Conlon, Xin Bi, Katherine J. Slovik, Jianting Shi, Hailey I. Edelstein, John S. Millar, Ali Javaheri, Marina Cuchel, Evanthia E. Pashos, Jahangir Iqbal, M. Mahmood Hussain, Robert A. Hegele, Wenli Yang, Stephen A. Duncan, Daniel J. Rader, Edward E. Morrisey
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1456-1466 (2017)
Abetalipoproteinemia (ABL) is an inherited disorder of lipoprotein metabolism resulting from mutations in microsomal triglyceride transfer protein (MTTP). In addition to expression in the liver and intestine, MTTP is expressed in cardiomyocytes, and
Externí odkaz:
https://doaj.org/article/d7125650f9fd4644a056f52767d91fcf
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 11, Pp 2261-2275 (2014)
Intestinal cholesterol absorption involves the chylomicron and HDL pathways and is dependent on microsomal triglyceride transfer protein (MTP) and ABCA1, respectively. Chylomicrons transport free and esterified cholesterol, whereas HDLs transport fre
Externí odkaz:
https://doaj.org/article/89b5ffcf45fd4b968583612544df40f9
Autor:
Arne Dikkers, Wijtske Annema, Jan Freark de Boer, Jahangir Iqbal, M. Mahmood Hussain, UweJ.F. Tietge
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 5, Pp 816-825 (2014)
Because apoB-containing lipoproteins are pro-atherogenic and their secretion by liver and intestine largely depends on microsomal triglyceride transfer protein (MTP) activity, MTP inhibition strategies are actively pursued. How decreasing the secreti
Externí odkaz:
https://doaj.org/article/5def5d6a8ff44c18a101ba5aa355c03a
Autor:
Amanda J Martinot, Mary Farrow, Lu Bai, Emilie Layre, Tan-Yun Cheng, Jennifer H Tsai, Jahangir Iqbal, John W Annand, Zuri A Sullivan, M Mahmood Hussain, James Sacchettini, D Branch Moody, Jessica C Seeliger, Eric J Rubin
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005351 (2016)
Mycobacterium tuberculosis (Mtb) mutants lacking rv1411c, which encodes the lipoprotein LprG, and rv1410c, which encodes a putative efflux pump, are dramatically attenuated for growth in mice. Here we show that loss of LprG-Rv1410 in Mtb leads to int
Externí odkaz:
https://doaj.org/article/3122182a17664a31b85cc45e21e4b8b4
Publikováno v:
Diseases, Vol 6, Iss 3, p 82 (2018)
The rapidly expanding field of bioactive lipids is exemplified by the many sphingolipids, which are structurally and functionally diverse molecules with significant physiologic functions. These sphingolipids are main constituents of cellular membrane
Externí odkaz:
https://doaj.org/article/312a0b8770704d8e9ccb5ebf54026aea