Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads

Autor: Huy Quoc Nguyen, Jagoree Roy, Björn Harink, Nikhil P Damle, Naomi R Latorraca, Brian C Baxter, Kara Brower, Scott A Longwell, Tanja Kortemme, Kurt S Thorn, Martha S Cyert, Polly Morrell Fordyce

Publikováno v: eLife, Vol 8 (2019)

Transient, regulated binding of globular protein domains to Short Linear Motifs (SLiMs) in disordered regions of other proteins drives cellular signaling. Mapping the energy landscapes of these interactions is essential for deciphering and perturbing

Externí odkaz: https://doaj.org/article/7c2396e28d9c4a068245caf34c7ea70c

Cell Biology: Deciphering the ABCs of SLiMs in G1-CDK Signaling

Autor: Martha S. Cyert, Jagoree Roy

Publikováno v: Curr Biol

Many protein-modifying enzymes recognize their substrates via docking motifs, but the range of functionally permissible motif sequences is often poorly defined. During eukaryotic cell division, cyclin-specific docking motifs help cyclin-dependent kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5e194fbe02e179adbbba3171bb5572
https://doi.org/10.1016/j.cub.2020.09.026

A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes

Autor: Shalini Muralidhar, Martha S. Cyert, Jainy J. Savla, Shujuan Li, Jagoree Roy, Yuji Nakada, Maimon E. Hubbi, Beverly A. Rothermel, Roger Foo, Shah R. Ali, Wilson Lek Wen Tan, Mahmoud S. Ahmed, Feng Xiao, Jesung Moon, Kareem A. Zidan, Magid S. Mohamed, Ivan Menendez-Montes, Ngoc Uyen Nhi Nguyen, Hesham A. Sadek, Diana C. Canseco, Victoria Le, Chukwuemeka George Anene-Nzelu, Xun Meng, Suwannee Thet, Mohammed Kanchwala, Elisa Villalobos, Nicholas T. Lam, Chao Xing, Joseph A. Hill, Waleed M. Elhelaly, Zhaoning Wang, Victor Le, Hamed W. El-Feky

Publikováno v: Nguyen, N U N, Canseco, D C, Xiao, F, Nakada, Y, Li, S, Lam, N T, Muralidhar, S A, Savla, J J, Hill, J A, Le, V, Zidan, K A, El-feky, H W, Wang, Z, Ahmed, M S, Hubbi, M E, Menendez-montes, I, Moon, J, Ali, S R, Le, V, Villalobos, E, Mohamed, M S, Elhelaly, W M, Thet, S, Anene-nzelu, C G, Tan, W L W, Foo, R S, Meng, X, Kanchwala, M, Xing, C, Roy, J, Cyert, M S, Rothermel, B A & Sadek, H A 2020, ' A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes ', Nature, vol. 582, no. 7811, pp. 271-276 . https://doi.org/10.1038/s41586-020-2228-6
Nature

A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through prol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159c9a7761d7e144ce14b016c92808b2
https://www.pure.ed.ac.uk/ws/files/155195562/ppnature17051.pdf

Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads

Autor: Kurt S. Thorn, Polly M. Fordyce, Naomi R. Latorraca, Scott A. Longwell, Björn Harink, Brian Baxter, Jagoree Roy, Tanja Kortemme, Nikhil P Damle, Martha S. Cyert, Kara Brower, Huy V. Nguyen

Publikováno v: eLife
eLife, Vol 8 (2019)

Transient, regulated binding of globular protein domains to Short Linear Motifs (SLiMs) in disordered regions of other proteins drives cellular signaling. Mapping the energy landscapes of these interactions is essential for deciphering and perturbing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23bac6753c903433fa381080685082f9
http://europepmc.org/articles/PMC6728138

Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads

Autor: Brian Baxter, Tanja Kortemme, Kurt S. Thorn, Jagoree Roy, Huy V. Nguyen, Polly M. Fordyce, Björn Harink, Nikhil P Damle, Martha S. Cyert, Kara Brower

Transient, regulated binding of globular protein domains to Short Linear Motifs (SLiMs) in disordered regions of other proteins drives cellular signaling. Mapping the energy landscapes of these interactions is essential for deciphering and therapeuti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e57ede1b7821538af898978cd424197
https://doi.org/10.1101/306779