Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Jagodzinska Barbara"'
Autor:
Xiaofei Wei, Campagna, Jesus J., Jagodzinska, Barbara, Dongwook Wi, Cohn, Whitaker, Lee, Jessica T., Chunni Zhu, Huang, Christine S., Molnár, László, Houser, Carolyn R., John, Varghese, Mody, Istvan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 8/13/2024, Vol. 121 Issue 33, p1-11, 35p
Akademický článek
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Autor:
Neil K. Garg, Rachel R. Knapp, Jesus Campagna, Sujyoti Chandra, Samantha Focht, Karen H. Gylys, Bryan J. Simmons, Patricia Spilman, Varghese John, Whitaker Cohn, Mikhail Melnik, Kanagasabai Vadivel, Jagodzinska Barbara, Chris Jean Elias, Tina Bilousova, Chunni Zhu
Publikováno v:
ACS chemical biology, vol 15, iss 6
ACS Chem Biol
ACS Chem Biol
We report the discovery of a novel class of compounds that function as dual inhibitors of the enzymes neutral sphingomyelinase-2 (nSMase2) and acetylcholinesterase (AChE). Inhibition of these enzymes provides a unique strategy to suppress the propaga
Autor:
Michael E. Jung, Dale E. Bredesen, Chris Jean Elias, Dongsheng Bai, Chunni Zhu, Mary Jo LaDu, Gregory M. Cole, Johnny Pham, Patricia Spilman, Michael Jun, Jesus Campagna, Jagodzinska Barbara, Asa Hatami, Tina Bilousova, Varghese John
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific reports, vol 8, iss 1
Scientific Reports
Scientific reports, vol 8, iss 1
Scientific Reports
We describe here the results from the testing of a small molecule first-in-class apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, A03, that increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic
Akademický článek
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C O bond formation in a microfluidic reactor: high yield S N Ar substitution of heteroaryl chlorides
Publikováno v:
Tetrahedron Letters. 57:2059-2062
This study describes our development of a novel and efficient procedure for C-O bond formation under mild conditions, for coupling heteroaryl chlorides with phenols or primary aliphatic alcohols. We utilized a continuous-flow microfluidic reactor for
Autor:
Josh Soler, Michael Jun, Varghese John, Tina Bilousova, Asa Hatami, Patricia Spilman, Chris Jean Elias, Mohammad Parvez Alam, Jagodzinska Barbara, Chunni Zhu, Jesus Campagna, Dongsheng Bai, Dale E. Bredesen
Publikováno v:
Alzheimer's & Dementia. 14
Autor:
Kanagasabai Vadivel, Karen H. Gylys, Tina Bilousova, Chris Jean Elias, Jesus Campagna, Jagodzinska Barbara, Mohammad Parvez Alam, Emily Miyoshi, Chunni Zhu, Varghese John
Publikováno v:
Biochemical and biophysical research communications, vol 499, iss 4
Targeting of molecular pathways involved in the cell-to-cell propagation of pathological tau species is a novel approach for development of disease-modifying therapies that could block tau pathology and attenuate cognitive decline in patients with Al
Autor:
Varghese John, Karen H. Gylys, Jagodzinska Barbara, Mikhail Melnik, Patricia Spilman, Chris Jean Elias, Bryan J. Simmons, Jesus Campagna, Michael Jun, Asa Hatami, Neil K. Garg, Tina Bilousova, Kanagasabai Vadivel, Whitaker Cohn, Chunni Zhu, Emily Miyoshi
Publikováno v:
Alzheimer's & Dementia. 15:P1294-P1295
Autor:
Varghese John, Patricia Spilman, Kanagasabai Vadivel, Tina Bilousova, Jesus Campagna, Jagodzinska Barbara, Michael Jun
Publikováno v:
Journal of molecular biology. 430(11)
The aspartyl protease BACE1 (BACE) has emerged as an appealing target for reduction of amyloid-β in Alzheimer's disease. The clinical fate of active-site BACE inhibitors may depend on potential side effects related to enzyme and substrate selectivit