5-Hydroxypyran-4-one derivatives as potential therapeutic iron-chelating agents

Autor: Junpei Li, Guoqing Zhang, Vincenzo Abbate, Jagoda Jurach, Xiaole Kong, Robert C. Hider

Publikováno v: ChemistrySelect. 1:297-300

Kojic acid can be condensed with amines via the Mannich reaction in good yield without protection of the phenolic group. Using this synthetic approach two tridentate chelators and a hexadentate chelator have been prepared. All three possess a high af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f66b309b4d56a63a48bd2f7bca05e59
https://doi.org/10.1002/slct.201600022

Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth

Autor: Robert C. Hider, Tao Zhou, Xiaole Kong, Junpei Li, Guoqing Zhang, Vincenzo Abbate, Selwa Alsam, Yongmin Ma, Jagoda Jurach, Osamah Al Rugaie, Eniola Olaleye

Publikováno v: Li, J, Olaleye, E, Kong, X, Zhou, T, Ma, Y, Jurach, J, Al Rugaie, O, Hider, R C, Zhang, G, Alsam, S & Abbate, V 2016, ' Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth ', Polymer, vol. 87, pp. 64-72 . https://doi.org/10.1016/j.polymer.2016.01.073

A series of linear poly (glycidyl methacrylate) (PGMA) polymers were synthesized via RAFT polymerization and conjugated with amine-containing 3-hydroxypyridin-4-ones (HPOs) to generate a panel of HPO-containing materials with controlled structures an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f236c2739770d09c73a6102ca02192
https://kclpure.kcl.ac.uk/en/publications/7d21ab5f-0c3c-4353-aee4-23d3cb854351