Cell contact guidance via sensing anisotropy of network mechanical resistance

Autor: Thrivikraman, Greeshma, Jagiełło, Alicja, Lai, Victor K., Johnson, Sandra L., Keating, Mark, Nelson, Alexander, Schultz, Billianne, Wang, Connie M., Levine, Alex J., Botvinick, Elliot L., Tranquillo, Robert T.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2021 Jul . 118(29), 1-11.

Externí odkaz: https://www.jstor.org/stable/27052526

Cell mediated remodeling of stiffness matched collagen and fibrin scaffolds.

Autor: Jagiełło, Alicja¹ (AUTHOR), Castillo, Ulysses¹ (AUTHOR), Botvinick, Elliot^1,2,3,4 (AUTHOR) elliot.botvinick@uci.edu

Publikováno v: Scientific Reports. 7/11/2022, Vol. 12 Issue 1, p1-15. 15p.

Rho kinase inhibition by AT13148 blocks pancreatic ductal adenocarinoma invasion and tumor growth

Autor: Rath, Nicola, Munro, June, Cutiongco, Marie Francene, Jagiełło, Alicja, Gadegaard, Nikolaj, McGarry, Lynn, Unbekandt, Mathieu, Michalopoulou, Evdokia, Kamphorst, Jurre J., Sumpton, David, Mackay, Gillian, Vennin, Claire, Pajic, Marina, Timpson, Paul, Olson, Michael F.

The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small molecule inhibitor AT13148 potently inhibits ROCK1 and ROCK2 kinases that regulate the actomyosin cytoskeleton. We previously report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::96f0ae94b7eaa0c2c79505a2a1048b29
https://eprints.gla.ac.uk/161312/7/161312.pdf

Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth.

Autor: Rath N; Cancer Research UK Beatson Institute, Glasgow, United Kingdom., Munro J; Cancer Research UK Beatson Institute, Glasgow, United Kingdom., Cutiongco MF; Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow, United Kingdom., Jagiełło A; Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow, United Kingdom., Gadegaard N; Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow, United Kingdom., McGarry L; Cancer Research UK Beatson Institute, Glasgow, United Kingdom., Unbekandt M; Cancer Research UK Beatson Institute, Glasgow, United Kingdom., Michalopoulou E; Cancer Research UK Beatson Institute, Glasgow, United Kingdom., Kamphorst JJ; Cancer Research UK Beatson Institute, Glasgow, United Kingdom.; Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Sumpton D; Cancer Research UK Beatson Institute, Glasgow, United Kingdom., Mackay G; Cancer Research UK Beatson Institute, Glasgow, United Kingdom., Vennin C; The Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, Australia.; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Kensington, Australia., Pajic M; The Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, Australia.; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Kensington, Australia., Timpson P; The Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, Australia.; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Kensington, Australia., Olson MF; Cancer Research UK Beatson Institute, Glasgow, United Kingdom. m.olson@beatson.gla.ac.uk.; Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

Publikováno v: Cancer research [Cancer Res] 2018 Jun 15; Vol. 78 (12), pp. 3321-3336. Date of Electronic Publication: 2018 Apr 18.