Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial cochlea.

Autor: de Haan S; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm 17177, Sweden.; Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA., Corbat AA; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm 17177, Sweden., Cederroth CR; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 17177, Sweden.; Translational Hearing Research, Tübingen Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, University of Tübingen, Tübingen 72074, Germany., Autrum LG; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm 17177, Sweden., Hankeova S; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm 17177, Sweden.; Department of Structural Biology, Genentech, South San Francisco, CA 94080, USA., Driver EC; Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA., Canlon B; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 17177, Sweden., Kelley MW; Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA., Andersson ER; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm 17177, Sweden.

Publikováno v: Development (Cambridge, England) [Development] 2024 Nov 01; Vol. 151 (21). Date of Electronic Publication: 2024 Nov 05.

Delivery of a Jagged1-PEG-MAL hydrogel with pediatric human bone cells regenerates critically sized craniofacial bone defects.

Autor: Kamalakar A; Department of Pediatric Otolaryngology, Emory University, Atlanta, United States., Tobin B; Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, United States.; School of Chemistry and Biomolecular Engineering, Georgia Tech College of Engineering, Atlanta, United States., Kaimari S; Department of Pediatric Otolaryngology, Emory University, Atlanta, United States.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, United States., Robinson MH; Department of Pediatric Otolaryngology, Emory University, Atlanta, United States., Toma AI; Department of Pediatric Otolaryngology, Emory University, Atlanta, United States.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, United States., Cha T; Department of Pediatric Otolaryngology, Emory University, Atlanta, United States., Chihab S; Department of Orthopedics, Emory University, Atlanta, United States., Moriarity I; Neuroscience Program in College of Sciences, Georgia Institute of Technology, Atlanta, United States., Gautam S; Department of Orthopedics, Emory University, Atlanta, United States., Bhattaram P; Department of Orthopedics, Emory University, Atlanta, United States.; The Atlanta Veterans Affairs Medical Center Atlanta, Atlanta, United States., Abramowicz S; Department of Pediatric Otolaryngology, Emory University, Atlanta, United States.; Department of Surgery, Division of Oral and Maxillofacial Surgery, Emory University, Atlanta, United States., Drissi H; Department of Orthopedics, Emory University, Atlanta, United States.; The Atlanta Veterans Affairs Medical Center Atlanta, Atlanta, United States.; Department of Cell Biology, Emory University, Atlanta, United States., Garcia A; Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, United States.; George W. Woodruff School of Mechanical Engineering, Georgia Tech College of Engineering, Atlanta, United States., Wood L; Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, United States.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, United States.; George W. Woodruff School of Mechanical Engineering, Georgia Tech College of Engineering, Atlanta, United States., Goudy SL; Department of Pediatric Otolaryngology, Children's Healthcare of Atlanta, Atlanta, United States.

Publikováno v: ELife [Elife] 2024 Oct 14; Vol. 13. Date of Electronic Publication: 2024 Oct 14.

Dysbiosis-activated IL-17-producing T cells promote skin immunopathological progression in mice deficient of the Notch ligand Jag1 in keratinocytes.

Autor: Song EH; The Molecular, Cellular, and Integrative Biosciences (MCIBS) Graduate Program, The Pennsylvania State University, PA, USA; Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center San Antonio, TX, USA., Garcia J Jr; Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center San Antonio, TX, USA., Xiong N; Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center San Antonio, TX, USA; Department of Medicine-Division of Dermatology and Cutaneous Surgery, University of Texas Health Science Center San Antonio, TX , USA. Electronic address: xiongn@uthscsa.edu.

Publikováno v: Journal of dermatological science [J Dermatol Sci] 2024 Oct; Vol. 116 (1), pp. 14-23. Date of Electronic Publication: 2024 Sep 06.

Jagged1-Notch1 Signaling Pathway Induces M1 Microglia to Disrupt the Barrier Function of Retinal Microvascular Endothelial Cells.

Autor: Wu X; School of Medicine, South China University of Technology, Guangzhou, China.; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Zhu H; School of Medicine, South China University of Technology, Guangzhou, China.; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Liu J; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Ouyang S; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Lyu Z; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Jin Y; School of Medicine, South China University of Technology, Guangzhou, China.; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Chen X; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Meng Q; School of Medicine, South China University of Technology, Guangzhou, China.; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Publikováno v: Current eye research [Curr Eye Res] 2024 Oct; Vol. 49 (10), pp. 1098-1106. Date of Electronic Publication: 2024 May 23.

Notch signaling mediated repressive effects of resveratrol in inducing caspasedependent apoptosis in MCF-7 breast cancer cells.

Autor: Pandey P; Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura- 140401, Punjab, India. shukla.pratibha1985@gmail.com., Ramniwas S; University Centre of Research and Development, University Institute of Biotechnology, Chandigarh University, Gharuan, Mohali, Punjab, India. seema.ramniwas@gmail.com., Seifeldin SA; Department of Clinical Laboratory Science, College of Applied Medical Science, University of Hail, Hail P.O. Box 2240, Saudi Arabia. s.seifeldin@uoh.edu.sa., Alshaghdali K; Department of Clinical Laboratory Science, College of Applied Medical Science, University of Hail, Hail P.O. Box 2240, Saudi Arabia. k.alshaghdali@uoh.edu.sa., Alharazi T; Department of Clinical Laboratory Science, College of Applied Medical Science, University of Hail, Hail P.O. Box 2240, Saudi Arabia. t.alharzi@uoh.edu.sa., Acar T; Department of Diagnostic Radiology, College of Applied Medical Sciences, University of Hail, Hail P.O. Box 2240, Saudi Arabia. t.acar@uoh.edu.sa., Upadhye VJ; Research and Development Cell (RDC), Parul Institute of Applied Sciences, Parul University, Tal Waghodia, Vadodara Gujarat. dr.vijaysemilo@gmail.com., Sharma N; School of Applied and Life sciences; Uttaranchal University, Dehradun. nishesh21@gmail.com., Khan F; Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India. fahadintegralian@gmail.com., Saeed A; Department of Clinical Laboratory Science, College of Applied Medical Science, University of Hail, Hail P.O. Box 2240, Saudi Arabia. am.saeed@uoh.edu.sa.

Publikováno v: Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2024 Sep 08; Vol. 70 (8), pp. 96-103. Date of Electronic Publication: 2024 Sep 08.