Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Jagesh V. Shah"'
Autor:
Ian Helstrup Nielsen, Anne Bruun Rovsing, Jacob Hørlück Janns, Emil Aagaard Thomsen, Albert Ruzo, Andreas Bøggild, Frederikke Nedergaard, Charlotte Thornild Møller, Thomas Boesen, Søren Egedal Degn, Jagesh V. Shah, Jacob Giehm Mikkelsen
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102318- (2024)
To fully utilize the potential of CRISPR-Cas9-mediated genome editing, time-restricted and targeted delivery is crucial. By modulating the pseudotype of engineered lentivirus-derived nanoparticles (LVNPs), we demonstrate efficient cell-targeted deliv
Externí odkaz:
https://doaj.org/article/5b0da4b8e2504d17b7dca8efcfd345d5
Autor:
Sarah A. Yunes, Jennifer L. S. Willoughby, Julian H. Kwan, Jessica M. Biagi, Niranjana Pokharel, Hang Gyeong Chin, Emily A. York, Kuan-Chung Su, Kelly George, Jagesh V. Shah, Andrew Emili, Scott E. Schaus, Ulla Hansen
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Factor quinolinone inhibitors (FQIs), a first-in-class set of small molecule inhibitors targeted to the transcription factor LSF (TFCP2), exhibit promising cancer chemotherapeutic properties. FQI1, the initial lead compound identified, unexpectedly i
Externí odkaz:
https://doaj.org/article/6ae848c8bada4a1bafa17d2db5c202d0
Autor:
Liron David, Laurel Martinez, Qiongchao Xi, Kameron A. Kooshesh, Ying Zhang, Jagesh V. Shah, Richard L. Maas, Hao Wu
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Piezo1 and 2 are evolutionarily conserved mechanosensory cation channels known to function on the cell surface by responding to external pressure and transducing a mechanically activated Ca 2+ current. Here we show that both Piezo1 and 2 also exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ab73a95f6c9ba5a28573843dda76a9
https://doi.org/10.1073/pnas.2213846120
https://doi.org/10.1073/pnas.2213846120
Autor:
Liron David, Laurel Martinez, Qiongchao Xi, Xueping Fan, Kameron A. Kooshesh, Ying Zhang, Jagesh V. Shah, Weining Lu, Richard L. Maas, Hao Wu
Piezo1 and 2 are evolutionarily conserved mechanosensory cation channels known to function on the cell surface by responding to external pressure and transducing a mechanically activated Ca2+ current. Here we show that both Piezo1 and 2 also exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58ab57fb1221651023d60a8ba5bb12f5
https://doi.org/10.1101/2022.04.12.488050
https://doi.org/10.1101/2022.04.12.488050
Autor:
Victor S Goldmacher, Charlene A Audette, Yinghua Guan, Eriene-Heidi Sidhom, Jagesh V Shah, Kathleen R Whiteman, Yelena V Kovtun
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117523 (2015)
The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules. To identify the mechanisms of this intracellular a
Externí odkaz:
https://doaj.org/article/e72da5b89d77491ea5ee1090969d22e4
Autor:
Sergine Brutus, Lorena Pantano, Cory V. Gerlach, Sarah A. Boswell, Shannan J. Ho Sui, Vishal S. Vaidya, Mira Pavkovic, Robert A. Everley, Jagesh V. Shah
Publikováno v:
Scientific Data, Vol 6, Iss 1, Pp 1-9 (2019)
Scientific Data
Scientific Data
Kidney fibrosis represents an urgent unmet clinical need due to the lack of effective therapies and an inadequate understanding of the molecular pathogenesis. We have generated a comprehensive and combined multi-omics dataset (proteomics, mRNA and sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f0d9d90b4b5ff171c8d1c1ad3c8140
http://link.springer.com/article/10.1038/s41597-019-0095-5
http://link.springer.com/article/10.1038/s41597-019-0095-5
Autor:
Dani L Bodor, João F Mata, Mikhail Sergeev, Ana Filipa David, Kevan J Salimian, Tanya Panchenko, Don W Cleveland, Ben E Black, Jagesh V Shah, Lars ET Jansen
Publikováno v:
eLife, Vol 3 (2014)
The centromere, responsible for chromosome segregation during mitosis, is epigenetically defined by CENP-A containing chromatin. The amount of centromeric CENP-A has direct implications for both the architecture and epigenetic inheritance of centrome
Externí odkaz:
https://doaj.org/article/974d5ffd5ef4400b878f5e6af958c8c0
Autor:
Jagesh V. Shah, Scott E. Schaus, Hyunjin Shin, Chandra Sekhar Pedamallu, Patrick Stoiber, Hang Gyeong Chin, Jennifer L.S. Willoughby, Mark P. Roberto, Kelly George, Ulla Hansen, Kevin Fitzgerald
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-15 (2020)
BMC Cancer
BMC Cancer
Background The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular carcinoma and colorectal ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583c229510c0f8416c29b009c689db12
https://doi.org/10.1186/s12885-020-07039-1
https://doi.org/10.1186/s12885-020-07039-1
Autor:
Andrea J Hartlerode, Yinghua Guan, Anbazhagan Rajendran, Kiyoe Ura, Gunnar Schotta, Anyong Xie, Jagesh V Shah, Ralph Scully
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49211 (2012)
Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several histone methyltransferases have
Externí odkaz:
https://doaj.org/article/51153115b6584b1b91bea854d1bd5d6d
Autor:
Christina Chaivorapol, Chamith Fonseka, Terry J. Fry, Shirisha Amatya, Zach Frye, Saurabh Paliwal, Jagesh V Shah, Samantha Davis, Patricia Cruite, Christopher Bandoro, Hina Iftikhar, Nikolas Balanis, Michael Laska, Lauren Pepper
Publikováno v:
Blood. 138:3983-3983
Introduction: The ability to deliver genes to specific cell types in vivo would have a profound therapeutic impact for a diverse set of diseases. For example, targeting T cells for in vivo delivery of a chimeric antigen receptor (CAR) to treat B cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3e0369233ad2f653cfce37fdbb546ce
https://doi.org/10.1182/blood-2021-149990
https://doi.org/10.1182/blood-2021-149990