Precancerous liver diseases do not cause increased mutagenesis in liver stem cells.

Autor: Nguyen, Luan¹ (AUTHOR), Jager, Myrthe¹ (AUTHOR), Lieshout, Ruby² (AUTHOR), de Ruiter, Petra E.² (AUTHOR), Locati, Mauro D.¹ (AUTHOR), Besselink, Nicolle¹ (AUTHOR), van der Roest, Bastiaan¹ (AUTHOR), Janssen, Roel¹ (AUTHOR), Boymans, Sander¹ (AUTHOR), de Jonge, Jeroen² (AUTHOR), IJzermans, Jan N. M.² (AUTHOR), Doukas, Michail² (AUTHOR), Verstegen, Monique M. A.² (AUTHOR), van Boxtel, Ruben³ (AUTHOR), van der Laan, Luc J. W.² (AUTHOR), Cuppen, Edwin^1,4 (AUTHOR) E.P.J.G.Cuppen@umcutrecht.nl, Kuijk, Ewart¹ (AUTHOR) e.w.kuijk-3@umcutrecht.nl

Publikováno v: Communications Biology. 11/18/2021, Vol. 4 Issue 1, p1-9. 9p.

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Autor: Verstegen, Monique M A, Roos, Floris J M, Burka, Ksenia, Gehart, Helmuth, Jager, Myrthe, de Wolf, Maaike, Bijvelds, Marcel J C, de Jonge, Hugo R, Ardisasmita, Arif I, van Huizen, Nick A, Roest, Henk P, de Jonge, Jeroen, Koch, Michael, Pampaloni, Francesco, Fuchs, Sabine A, Schene, Imre F, Luider, Theo M, van der Doef, Hubert P J, Bodewes, Frank A J A, de Kleine, Ruben H J, Spee, Bart, Kremers, Gert-Jan, Clevers, Hans, IJzermans, Jan N M, Cuppen, Edwin, van der Laan, Luc J W, Interne geneeskunde GD, dCSCA RMSC-1, Sub SBR overig, Faculteit Diergeneeskunde, Dep Biologie, CS_STEM

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, 10(1):21900. Nature Publishing Group
Scientific Reports, 10(1). Nature Publishing Group
Scientific Reports, 10(1). NLM (Medline)
Scientific Reports

The development, homeostasis, and repair of intrahepatic and extrahepatic bile ducts are thought to involve distinct mechanisms including proliferation and maturation of cholangiocyte and progenitor cells. This study aimed to characterize human extra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6f010f1aa6e0ac8ce7c76b8cec33f6
https://doaj.org/article/eb9e7d98f7234f40b94f21db6d99f8db

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On the origin of cancer: Mutation accumulation in healthy and precancerous adult stem cells

Autor: Jager, Myrthe

Cancer is caused by the sequential accumulation of driver mutations in the genome of a single cell, allowing the clonal expansion of this cell. Several factors can increase the risk of developing cancer, such as old age, genetic predisposition, expos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3cc6c6828f9cde7dd5efe84a221c2b2d
https://dspace.library.uu.nl/handle/1874/370154

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