Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Jagdamba P. Maikhuri"'
Autor:
Santosh K. Yadav, Aastha Pandey, Lokesh Kumar, Archana Devi, Bhavana Kushwaha, Rahul Vishvkarma, Jagdamba P. Maikhuri, Singh Rajender, Gopal Gupta
Publikováno v:
Reproductive Biology and Endocrinology, Vol 16, Iss 1, Pp 1-22 (2018)
Abstract Background Spermatogenesis in most mammals (including human and rat) occurs at ~ 3 °C lower than body temperature in a scrotum and fails rapidly at 37 °C inside the abdomen. The present study investigates the heat-sensitive transcriptome a
Externí odkaz:
https://doaj.org/article/b1119588179a4bd6b5d05f33616ef629
Publikováno v:
Reproduction. 162:339-351
Sperm in most mammalian species including rat, mice and human are kept completely quiescent (motionless) and viable for up to a few weeks in the cauda epididymis before ejaculation. Vigorous motility is initiated almost instantly upon sperm release f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0d64b945ae0725380a5d1a24e3572e
https://doi.org/10.1530/rep-21-0202
https://doi.org/10.1530/rep-21-0202
Publikováno v:
International Journal of Urology. 28:225-240
Objectives To identify the sequence of inflammation-driven signaling cascades and other molecular events that might cause tumor-like transformation of prostatic cells. Methods Cytokine array analysis, Reactome and STRING analysis, immunoblotting, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34826e0c5d8b3cb895060f98b5ee7383
https://doi.org/10.1111/iju.14431
https://doi.org/10.1111/iju.14431
Autor:
Bineta Singh, Gopal Gupta, Santosh Kumar Yadav, Singh Rajender, Rahul Vishvkarma, Aastha Pandey, Jagdamba P. Maikhuri
Publikováno v:
Molecular Reproduction and Development. 86:1921-1939
Meiosis is the defining event of spermatogenesis. Spermatocytes undergo meiosis to give rise to round spermatids, which in turn metamorphose to flagellated spermatozoa that mature in the epididymis. To characterize the dynamics of gene expression dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24baa25c8fc11086e7fa0d46204a4d1a
https://doi.org/10.1002/mrd.23278
https://doi.org/10.1002/mrd.23278
Autor:
Monika Sharma, Lokesh Kumar, Ashish Jain, Vikas Verma, Vikas Sharma, Bhavana Kushwaha, Nand Lal, Lalit Kumar, Tara Rawat, Anil K Dwivedi, Jagdamba P Maikhuri, Vishnu L Sharma, Gopal Gupta
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67365 (2013)
Unlike somatic cells, sperm have several-fold more available-thiols that are susceptible to redox-active agents. The present study explains the mechanism behind the instant sperm-immobilizing and trichomonacidal activities of pyrrolidinium pyrrolidin
Externí odkaz:
https://doaj.org/article/caebfea36bc54710a5767495bec178dd
Autor:
Nidhi Srivastava, Jagdamba P. Maikhuri, Gopal Gupta, Dhanaraju Mandalapu, Mohammad Imran Siddiqi, Sanjay Krishna, Jawahar Lal, Praveen K. Shukla, Brijesh Kumar, Mahendra Shukla, Sonal Gupta, Bhavana Singh Chauhan, Bhavana Kushwaha, Vishnu L. Sharma, Renu Tripathi, Koneni V. Sashidhara, Pratiksha Singh, Ravi Goyani
Publikováno v:
European Journal of Medicinal Chemistry. 143:632-645
Sexually transmitted diseases like trichomoniasis along with opportunistic fungal infections like candidiasis are major global health burden in female reproductive health. In this context a novel non-nitroimidazole class of substituted carbamothioic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8ba7575419bdcc6c05d6514110cfe2
https://doi.org/10.1016/j.ejmech.2017.11.060
https://doi.org/10.1016/j.ejmech.2017.11.060
Autor:
Komal Sharma, Anil Kumar Dwivedi, Santosh Kumar Yadav, Monika Sharma, Sarvesh Paliwal, Shweta Sharma, Ajay Kumar Singh Rawat, Pankaj Dwivedi, Prabhat Ranjan Mishra, Gopal Gupta, Satish Agrawal, Vikas Sharma, Jagdamba P. Maikhuri
Publikováno v:
International Journal of Biological Macromolecules. 104:1345-1358
Addressing multidrug resistant stage of breast cancer is an impediment for chemotherapy. Moreover, breast cancer chemotherapy has potential enduring confrontations i.e. related toxicity including effect on fertility of young female patients. The co-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe98660af9110a03014c915eea3fa3f2
https://doi.org/10.1016/j.ijbiomac.2017.06.005
https://doi.org/10.1016/j.ijbiomac.2017.06.005
Novel aryl piperazines for alleviation of ‘andropause’ associated prostatic disorders and depression
Autor:
Gopal Gupta, Dhanaraju Mandalapu, DS Pandey, Mohammad Imran Siddiqi, Dilip Kumar Tanpula, Nidhi Singh, Mahendra Shukla, Surabhi Singh, Vishnu L. Sharma, Jawahar Lal, Seema Singh, Vikas Sharma, Santosh Kumar Yadav, Jagdamba P. Maikhuri, Shubha Shukla, Sonal Gupta
Publikováno v:
European Journal of Medicinal Chemistry. 132:204-218
A series of seventeen piperazine derivatives have been synthesized and biologically evaluated for the management of andropause-associated prostatic disorders and depression. Five compounds 16, 19, 20, 21 and 22 significantly inhibited proliferation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddc1c4897f3cb8e13d54bce4020f245
https://doi.org/10.1016/j.ejmech.2017.03.036
https://doi.org/10.1016/j.ejmech.2017.03.036
Autor:
Nidhi Singh, Mohammad Imran Siddiqi, Jitendra Kumar, Dilip Kumar Tanpula, Jagdamba P. Maikhuri, Bhavana Kushwaha, Gopal Gupta, Dhanaraju Mandalapu, Vishnu L. Sharma, Sonal Gupta, Satya Narayan Sankhwar, Jawahar Lal, Mahendra Shukla
Publikováno v:
European Journal of Medicinal Chemistry. 124:820-839
Trichomoniasis is the most prevalent, non-viral sexually transmitted diseases (STD) caused by amitochondriate protozoan Trichomonas vaginalis. Increased resistance of T. vaginalis to the marketed drug Metronidazole necessitates the development of new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7938cf9c8922c8e2d342db646e42adae
https://doi.org/10.1016/j.ejmech.2016.09.006
https://doi.org/10.1016/j.ejmech.2016.09.006
Autor:
Jagdamba P. Maikhuri, Lokesh Kumar, Singh Rajender, Sujit Kumar Mohanty, Gopal Gupta, Vikas Sharma
Publikováno v:
Molecular and Cellular Endocrinology. 431:12-23
Epigenetic repression of Androgen Receptor (AR) gene by hypermethylation of its promoter causes resistance in prostate cancer (CaP) to androgen deprivation therapy with anti-androgens. Some dietary phytocompounds like quercetin (Q) and curcumin (C) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf4b16e6589a8adfd8e8f6794525edc
https://doi.org/10.1016/j.mce.2016.04.024
https://doi.org/10.1016/j.mce.2016.04.024