Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jagannath Maharana"'
Autor:
Manish K. Yadav, Parishmita Sarma, Jagannath Maharana, Manisankar Ganguly, Sudha Mishra, Nashrah Zaidi, Annu Dalal, Vinay Singh, Sayantan Saha, Gargi Mahajan, Saloni Sharma, Mohamed Chami, Ramanuj Banerjee, Arun K. Shukla
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The Hydroxycarboxylic acid receptor 2 (HCA2), also known as the niacin receptor or GPR109A, is a prototypical GPCR that plays a central role in the inhibition of lipolytic and atherogenic activities. Its activation also results in vasodilati
Externí odkaz:
https://doaj.org/article/81a025e0280946b39508480f0e82854e
Autor:
Mithu Baidya, Madhu Chaturvedi, Hemlata Dwivedi-Agnihotri, Ashutosh Ranjan, Dominic Devost, Yoon Namkung, Tomasz Maciej Stepniewski, Shubhi Pandey, Minakshi Baruah, Bhanupriya Panigrahi, Parishmita Sarma, Manish K. Yadav, Jagannath Maharana, Ramanuj Banerjee, Kouki Kawakami, Asuka Inoue, Jana Selent, Stéphane A. Laporte, Terence E. Hébert, Arun K. Shukla
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
G protein-coupled receptors (GPCRs) are integral membrane proteins and the largest class of drug targets in the human genome. Here, Baidya et al. show that a synthetic antibody can be used to modulate GPCR trafficking and signaling in live cells.
Externí odkaz:
https://doaj.org/article/b914c159b8f9404cb1ff77ff55de3886
Autor:
Eshan Ghosh, Hemlata Dwivedi, Mithu Baidya, Ashish Srivastava, Punita Kumari, Tomek Stepniewski, Hee Ryung Kim, Mi-Hye Lee, Jaana van Gastel, Madhu Chaturvedi, Debarati Roy, Shubhi Pandey, Jagannath Maharana, Ramon Guixà-González, Louis M. Luttrell, Ka Young Chung, Somnath Dutta, Jana Selent, Arun K. Shukla
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3287-3299.e6 (2019)
Summary: Desensitization, signaling, and trafficking of G-protein-coupled receptors (GPCRs) are critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of βarrs (βarr1 and 2) share a high degree of sequence
Externí odkaz:
https://doaj.org/article/6c89aacecc9d4a92bef3658962de7d66
Autor:
Jagannath Maharana, Parishmita Sarma, Manish K. Yadav, Sayantan Saha, Vinay Singh, Shirsha Saha, Mohamed Chami, Ramanuj Banerjee, Arun K. Shukla
Publikováno v:
Molecular Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b35e062810ec825572670d2fd57f545f
https://doi.org/10.1016/j.molcel.2023.04.025
https://doi.org/10.1016/j.molcel.2023.04.025
Autor:
Manish K. Yadav, Ravi Yadav, Parishmita Sarma, Jagannath Maharana, Chahat Soni, Sayantan Saha, Vinay Singh, Manisankar Ganguly, Shirsha Saha, Htet A. Khant, Ramanuj Banerjee, Arun K. Shukla, Cornelius Gati
The complement cascade is an integral part of innate immunity, and it plays a crucial role in our body’s innate immune response including combating microbial infections. Activation of the complement cascade results in the generation of multiple pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f50f6f8dedefc3d25c765c773108342b
https://doi.org/10.1101/2023.02.09.527835
https://doi.org/10.1101/2023.02.09.527835
Autor:
Shirsha Saha, Jagannath Maharana, Manish K. Yadav, Parishmita Sarma, Vinay Singh, Samanwita Mohapatra, Chahat Soni, Sayantan Saha, Sudha Mishra, Manisankar Ganguly, Mohamed Chami, Ramanuj Banerjee, Arun K. Shukla
Activation of the complement cascade is a critical part of our innate immune response against invading pathogens, and it operates in a concerted fashion with the antibodies and phagocytic cells towards the clearance of pathogens. The complement pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c0abc1442dcb8e0b5da8e1639b48267
https://doi.org/10.1101/2023.01.14.524051
https://doi.org/10.1101/2023.01.14.524051
Autor:
Jagannath Maharana, Parishmita Sarma, Manish K. Yadav, Sayantan Saha, Vinay Singh, Shirsha Saha, Mohamed Chami, Ramanuj Banerjee, Arun K. Shukla
Agonist-induced phosphorylation of G protein-coupled receptors (GPCRs) is a key determinant for the binding and activation of multifunctional regulatory proteins known as β-arrestins (βarrs). Although the primary sequence and phosphorylation patter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc0d2eda1b565071660268d7b36c911b
https://doi.org/10.1101/2022.10.10.511556
https://doi.org/10.1101/2022.10.10.511556
Autor:
Parishmita Sarma, Hye-Jin Yoon, Carlo Marion C. Carino, Deeksha S, Ramanuj Banerjee, Yaejin Yun, Jeongsek Ji, Kyungjin Min, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Xue Rui, Yubo Cao, Kouki Kawakami, Poonam Kumari, Yu-Chih Chen, Kathryn E. Luker, Manish K. Yadav, Ashutosh Ranjan, Madhu Chaturvedi, Jagannath Maharana, Mithu Baidya, Prem N. Yadav, Gary D. Luker, Stéphane A. Laporte, Xin Chen, Asuka Inoue, Hyung Ho Lee, Arun K. Shukla
Chemokine receptors constitute an important subfamily of G protein-coupled receptors (GPCRs), and they are critically involved in a broad range of immune response mechanisms. Ligand promiscuity among these receptors makes them an interesting target t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b46111109a2a0f8be1f755063459da6
https://doi.org/10.1101/2022.06.06.494935
https://doi.org/10.1101/2022.06.06.494935
Publikováno v:
Curr Opin Struct Biol
Agonist-induced recruitment of β-arrestins (βarrs) to G protein-coupled receptors (GPCRs) plays a central role in regulating the spatio-temporal aspects of GPCR signaling. Several recent studies have provided novel structural and functional insight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737047f06d26f5c3c6e9bf116578a322
https://pubmed.ncbi.nlm.nih.gov/35738165
https://pubmed.ncbi.nlm.nih.gov/35738165
Autor:
Arun K. Shukla, Jagannath Maharana
Publikováno v:
Nature Structural & Molecular Biology. 28:331-333
The interaction of G protein–coupled receptors (GPCRs) with heterotrimeric G proteins plays a critical role in signal transduction processes, and multiple GPCR–G protein complexes reconstituted in detergent micelles have been visualized using cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0070271433645bf5f3431910cd6cfdbe
https://doi.org/10.1038/s41594-021-00581-x
https://doi.org/10.1038/s41594-021-00581-x