Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jaganathan Lakshmanan"'
Autor:
Jaganathan Lakshmanan, Baochun Zhang, Kalen Wright, Amierreza T. Motameni, Vaitheesh L. Jaganathan, David J. Schultz, Carolyn M. Klinge, Brian G. Harbrecht
Publikováno v:
Journal of Functional Foods, Vol 64, Iss , Pp 103637- (2020)
Tender coconut water (TCW) is a natural plant product rich in phytochemicals and protects against toxic liver injury. However, the mechanism by which TCW inhibits inflammation and tissue damage is unknown. We examined the effect of TCW on primary rat
Externí odkaz:
https://doaj.org/article/81a97836f3ef4094af2bb24be3cc5722
Autor:
Melissa A Metzler, Srirangapatnam G Venkatesh, Jaganathan Lakshmanan, Anne L Carenbauer, Sara M Perez, Sarah A Andres, Savitri Appana, Guy N Brock, James L Wittliff, Douglas S Darling
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125153 (2015)
ObjectiveThe transcription factor networks that drive parotid salivary gland progenitor cells to terminally differentiate, remain largely unknown and are vital to understanding the regeneration process.MethodologyA systems biology approach was taken
Externí odkaz:
https://doaj.org/article/0c59e18eb396487ebd197a39f4fd60e0
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:2811-2821
Abstract: Adaptogens were initially recognized as stress-resistance inducing compounds. Recent studies reveal that adaptogens are pleiotropically-acting chemical constituents that can be isolated from traditional herbs. They are gaining increasing at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b65d85cdeae682ea72a7ad7f78cc813
https://doi.org/10.2174/1871520622666220408091610
https://doi.org/10.2174/1871520622666220408091610
Publikováno v:
Molecular and Cellular Biochemistry. 441:89-98
Primary liver cancer (hepatocellular carcinoma, HCC) is a leading cause of cancer-related deaths, and alternative ways to treat this disease are urgently needed. In recent years, novel approaches to cancer treatment have been based on microRNAs, smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707cf953d0c03291d8d9bc40ee606c31
https://doi.org/10.1007/s11010-017-3176-9
https://doi.org/10.1007/s11010-017-3176-9
Autor:
Baochun Zhang, Jaganathan Lakshmanan, David J. Schultz, Carolyn M. Klinge, Vaitheesh L. Jaganathan, Amierreza T. Motameni, Brian G. Harbrecht, Kalen Wright
Publikováno v:
Journal of Functional Foods, Vol 64, Iss, Pp 103637-(2020)
Tender coconut water (TCW) is a natural plant product rich in phytochemicals and protects against toxic liver injury. However, the mechanism by which TCW inhibits inflammation and tissue damage is unknown. We examined the effect of TCW on primary rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f832faa3a33a09ba8c486abe8ff912a
https://doi.org/10.1016/j.jff.2019.103637
https://doi.org/10.1016/j.jff.2019.103637
Autor:
Jason W. Smith, Jaganathan Lakshmanan, Charles W. Kimbrough, Brian G. Harbrecht, Andrea Gentile, Paul J. Matheson, Baochun Zhang, Matthew V. Benns, Matthew R. Woeste
Publikováno v:
Surgery. 158:1095-1101
Introduction The production of excessive amounts of nitric oxide (NO) through inducible nitric oxide synthase (iNOS) contributes to organ injury, inflammation, and mortality after shock. Resveratrol (RSV) is a natural polyphenol that decreases shock-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b953943507147d4e1ad1e3c9224fa85
https://doi.org/10.1016/j.surg.2015.07.012
https://doi.org/10.1016/j.surg.2015.07.012
Publikováno v:
The Journal of surgical research. 221
Background AMP-activated protein kinase (AMPK) regulates several metabolic pathways in hepatocytes that are critical to the hepatic response to sepsis and shock. Induction of nitric oxide synthesis is an important response to sepsis, inflammation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7752c937963dc3509f40c983058c113
https://pubmed.ncbi.nlm.nih.gov/29229115
https://pubmed.ncbi.nlm.nih.gov/29229115
Publikováno v:
Journal of Cellular Biochemistry. 116:133-141
Excessive nitric oxide from the inducible nitric oxide synthase (iNOS) increases shock-induced hepatic injury, hepatic dysfunction, inflammation, and mortality in animal models. Cytokines increase the expression of iNOS in hepatocytes, but the signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8bcac04f5e64fd009121707d8329787
https://doi.org/10.1002/jcb.24951
https://doi.org/10.1002/jcb.24951
Autor:
Rifaat Shody El-Mallakh, Ratnam S. Seelan, John I. Stagner, Muthusamy Thangavel, Jaganathan Lakshmanan, Robert Vadnal, Manuel F. Casanova, Ranga N. Parthasarathy, Latha K. Parthasarathy
Publikováno v:
Journal of Neuroscience Research. 92:927-936
Valproic acid (VPA) is commonly used to treat bipolar disorder (BD), but its therapeutic role has not been clearly elucidated. To gain insights into VPA's mechanism of action, proteomic analysis was used to identify differentially expressed proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76fd69d0849e63a7122ec3534af7e5e1
https://doi.org/10.1002/jnr.23373
https://doi.org/10.1002/jnr.23373
Publikováno v:
Shock. 39:70-76
Adenosine 3',5'-cyclic adenosine monophosphate (cAMP) activates intracellular signaling by regulating protein kinase A, calcium influx, and cAMP-binging guanine nucleotide exchange factors (Epac [exchange protein directly activated by cAMP] or cAMP-G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb72aebabac58170a56950ee572dfc86
https://doi.org/10.1097/shk.0b013e3182760530
https://doi.org/10.1097/shk.0b013e3182760530