Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jagan M. R. Pongubala"'
Autor:
Jagan M. R. Pongubala, Cornelis Murre
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Higher-order spatial organization of the genome into chromatin compartments (permissive and repressive), self-associating domains (TADs), and regulatory loops provides structural integrity and offers diverse gene regulatory controls. In particular, c
Externí odkaz:
https://doaj.org/article/bc78fc34b63b43f78981c313fa50bd69
Autor:
Dasaradhi Palakodeti, Arpita Prusty, Sameena Nikhat, Jagan M. R. Pongubala, Cornelis Murre, Anurupa Devi Yadavalli, Priyanka K Narayan
Publikováno v:
Proc Natl Acad Sci U S A
The commitment of hematopoietic multipotent progenitors (MPPs) toward a particular lineage involves activation of cell type–specific genes and silencing of genes that promote alternate cell fates. Although the gene expression programs of early–B
Autor:
Cornelis Murre, Jagan M. R. Pongubala
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Higher-order spatial organization of the genome into chromatin compartments (permissive and repressive), self-associating domains (TADs), and regulatory loops provides structural integrity and offers diverse gene regulatory controls. In particular, c
The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination
Autor:
David G. Schatz, Jagan M. R. Pongubala, Craig H. Bassing, Anurupa Devi Yadavalli, Huseyin Saribasak, Anamika Bhattacharyya, Rebecca A Glynn, Elizabeth Corbett, Rahul Arya, Helen A. Beilinson, Jianxiong Xiao, Charline Miot, Jessica M. Jones
Publikováno v:
The Journal of experimental medicine. 218(10)
Immunoglobulin and T cell receptor gene assembly depends on V(D)J recombination initiated by the RAG1-RAG2 recombinase. The RAG1 N-terminal region (NTR; aa 1–383) has been implicated in regulatory functions whose influence on V(D)J recombination an
Autor:
Sreenivasulu Kurukuti, Ravi Boya, Sameena Nikhat, Dasaradhi Palakodeti, Jagan M. R. Pongubala, Anurupa Devi Yadavalli
Publikováno v:
Nucleic Acids Research
Genome organization in 3D nuclear-space is important for regulation of gene expression. However, the alterations of chromatin architecture that impinge on the B cell-fate choice of multi-potent progenitors are still unclear. By integrating in situ Hi
Publikováno v:
Seminars in Immunology. 20:228-235
Considerable progress is being achieved in the analysis of gene regulatory networks that direct cell fate decisions within the hematopoietic system. In addition to transcription factors that are pivotal for cell fate specification and commitment, rec
Autor:
Tamar Hashimshony, Catherine M. Sawai, Harinder Singh, Kristen Johnson, Jagan M. R. Pongubala, Jane A. Skok, Iannis Aifantis
Publikováno v:
Immunity. 28:335-345
Productive rearrangement of the immunoglobulin heavy-chain locus triggers a major developmental checkpoint that promotes limited clonal expansion of pre-B cells, thereby culminating in cell-cycle arrest and rearrangement of light-chain loci. By using
Autor:
Thomas Treiber, Eric Bertolino, Daniel L. Northrup, Rudolf Grosschedl, Kay L. Medina, Matthew Thomas, David Allman, Jagan M. R. Pongubala, Harinder Singh, David W. Lancki
Publikováno v:
Nature Immunology
Alternative lineage restriction and B cell fate commitment require the transcription factor Pax5, but the function of early B cell factor (EBF) in these processes remains mostly unexplored. Here we show that in the absence of EBF, 'expandable' and cl
Autor:
Harinder Singh, Jagan M. R. Pongubala
Publikováno v:
Current Opinion in Immunology. 18:116-120
Considerable progress has been achieved in the identification and analysis of regulatory molecules that orchestrate B and T cell fate determination. IL-7 and Notch signaling appear to represent analogous pathways that direct B and T cell fates, respe
Autor:
Matthias Kieslinger, Rodney P. DeKoter, Kay L. Medina, Jagan M. R. Pongubala, David W. Lancki, Karen L. Reddy, Harinder Singh, Rudolf Grosschedl
Publikováno v:
Developmental Cell
The generation of B lymphocyte precursors is dependent on the combinatorial action of the transcription factors PU.1, Ikaros, E2A, EBF, and Pax-5. Loss of PU.1 results in a severe reduction in Flk2+, IL-7R+ lymphoid progenitors as well as impaired ex