Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jagadish Hindupur"'
Autor:
Natalie Landeck, Katherine E. Strathearn, Daniel Ysselstein, Kerstin Buck, Sayan Dutta, Siddhartha Banerjee, Zhengjian Lv, John D. Hulleman, Jagadish Hindupur, Li-Kai Lin, Sonal Padalkar, Lia A. Stanciu, Yuri L. Lyubchenko, Deniz Kirik, Jean-Christophe Rochet
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-23 (2020)
Abstract Background α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson’s disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics th
Externí odkaz:
https://doaj.org/article/577ae13724214a3bac084228b03fe4b4
Autor:
Alexey V Krasnoslobodtsev, Jie Peng, Josephat M Asiago, Jagadish Hindupur, Jean-Christophe Rochet, Yuri L Lyubchenko
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38099 (2012)
Alpha-synuclein (α-Syn) is a 140 aa presynaptic protein which belongs to a group of natively unfolded proteins that are unstructured in aqueous solutions. The aggregation rate of α-Syn is accelerated in the presence of physiological levels of cellu
Externí odkaz:
https://doaj.org/article/63684dba33494352867812e1cb35e2dc
Autor:
Yuri L. Lyubchenko, Sonal Padalkar, John D. Hulleman, Siddhartha Banerjee, Li-Kai Lin, Lia Stanciu, Katherine E. Strathearn, Zhengjian Lv, Daniel Ysselstein, Deniz Kirik, Natalie Landeck, Kerstin Buck, Sayan Dutta, Jagadish Hindupur, Jean-Christophe Rochet
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-23 (2020)
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-23 (2020)
Background α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson’s disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics the human f
Autor:
Landeck, Natalie, Strathearn, Katherine E., Ysselstein, Daniel, Buck, Kerstin, Sayan Dutta, Siddhartha Banerjee, Zhengjian Lv, Hulleman, John D., Jagadish Hindupur, Li-Kai Lin, Padalkar, Sonal, Stanciu, Lia A., Lyubchenko, Yuri L., Kirik, Deniz, Rochet, Jean-Christophe
Additional file 1: Figure S1. Differences in antibody recognition of the different aSyn variants. Related to Fig. 3. Figure S2. Human/mouse mismatches at positions 121 and 122 do not affect the ability of aSyn to form Proteinase K-resistant aggregate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b090ecc79ebfb5a10faebab30416b2af
Autor:
George P. McCabe, Siddhartha Banerjee, Kerstin Buck, Jean-Christophess Rochet, Zhengjian Lv, Katherine E. Strathearn, Li-Kai Lin, Yuri L. Lyubchenko, John D. Hulleman, Sayan Dutta, Natalie Landeck, Sonal Padalkar, Lia Stanciu, Deniz Kirik, Daniel Ysselstein, Jagadish Hindupur
α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson’s disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics the human familial PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1640699a2db2538440fc7e73a4ff8214
https://doi.org/10.1101/700377
https://doi.org/10.1101/700377
Autor:
Jeremy L. Schieler, Fang Liu, V. Jo Davisson, Jagadish Hindupur, Junyi Zhu, Jean-Christophe Rochet, Jamie L. Nguyen, Karl V. Wood, Katie J. Ruf, Connie C. Bonham
Publikováno v:
Free Radical Biology and Medicine. 45:242-255
Parkinson's disease (PD) is a neurologic disorder characterized by dopaminergic cell death in the substantia nigra. PD pathogenesis involves mitochondrial dysfunction, proteasome impairment, and alpha-synuclein aggregation, insults that may be especi
Autor:
Jean-Christophe Rochet, Ivan L. Volkov, Yuri L. Lyubchenko, Josephat M. Asiago, Jagadish Hindupur, Alexey V. Krasnoslobodtsev
Publikováno v:
Biochemistry. 52(42)
Misfolding and subsequent aggregation of alpha-synuclein (α-Syn) protein are critically involved in the development of several neurodegenerative diseases, including Parkinson’s disease (PD). Three familial single point mutations, A30P, E46K, and A
Autor:
Yuri L. Lyubchenko, Alexey V. Krasnoslobodtsev, Jie Peng, Jagadish Hindupur, Josephat M. Asiago, Jean-Christophe Rochet
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 5, p e38099 (2012)
PLoS ONE, Vol 7, Iss 5, p e38099 (2012)
Alpha-synuclein (α-Syn) is a 140 aa presynaptic protein which belongs to a group of natively unfolded proteins that are unstructured in aqueous solutions. The aggregation rate of α-Syn is accelerated in the presence of physiological levels of cellu
Autor:
Ashraf G. Madian, Naomi Diaz-Maldonado, John D. Hulleman, Jean-Christophe Rochet, Fred E. Regnier, Jagadish Hindupur, Vartika Mishra, Cyril M. Kay, Emmanuel Guigard
Publikováno v:
Molecularcellular proteomics : MCP. 11(2)
Mutations in the gene encoding DJ-1 have been identified in patients with familial Parkinson's disease (PD) and are thought to inactivate a neuroprotective function. Oxidation of the sulfhydryl group to a sulfinic acid on cysteine residue C106 of DJ-