T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.

Autor: Arunachalam PS; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Charles TP; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA., Joag V; Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Bollimpelli VS; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA., Scott MKD; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.; Center for Biomedical Informatics, Department of Medicine, Stanford University, Stanford, CA, USA., Wimmers F; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Burton SL; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA., Labranche CC; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Petitdemange C; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA.; HIV Inflammation and Persistence Unit, Institut Pasteur, Paris, France., Gangadhara S; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA., Styles TM; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA., Quarnstrom CF; Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Walter KA; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Ketas TJ; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Legere T; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA., Jagadeesh Reddy PB; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA.; Pfizer, Andover, MA, USA., Kasturi SP; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA., Tsai A; BioLegend, San Diego, CA, USA., Yeung BZ; BioLegend, San Diego, CA, USA., Gupta S; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Tomai M; 3M Corporate Research and Materials Lab, Saint Paul, MN, USA., Vasilakos J; 3M Drug Delivery Systems, Saint Paul, MN, USA., Shaw GM; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kang CY; Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, Canada., Moore JP; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Subramaniam S; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Khatri P; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.; Center for Biomedical Informatics, Department of Medicine, Stanford University, Stanford, CA, USA., Montefiori D; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Kozlowski PA; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Derdeyn CA; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA. cderdey@emory.edu., Hunter E; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA. ehunte4@emory.edu., Masopust D; Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA. masopust@umn.edu., Amara RR; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA. ramara@emory.edu., Pulendran B; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.

Publikováno v: Nature medicine [Nat Med] 2020 Jun; Vol. 26 (6), pp. 932-940. Date of Electronic Publication: 2020 May 11.