Zobrazeno 1 - 10
of 1 239
pro vyhledávání: '"Jaffer A. Ajani"'
Autor:
Sarina A. Piha-Paul, Chieh Tseng, Cheuk Hong Leung, Ying Yuan, Daniel D. Karp, Vivek Subbiah, David Hong, Siqing Fu, Aung Naing, Jordi Rodon, Milind Javle, Jaffer A. Ajani, Kanwal P. Raghav, Neeta Somaiah, Gordon B. Mills, Apostolia M. Tsimberidou, Xiaofeng Zheng, Ken Chen, Funda Meric-Bernstam
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Cancer cells with BRCA1/2 deficiencies are sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. We evaluated the efficacy of talazoparib in DNA-Damage Repair (DDR)-altered patients. In this phase II trial, patients were enrolled onto
Externí odkaz:
https://doaj.org/article/1e0d0ae9bd434d9dbecfece7f428357b
Autor:
Yun Seong Jeong, Young-Gyu Eun, Sung Hwan Lee, Sang-Hee Kang, Sun Young Yim, Eui Hyun Kim, Joo Kyung Noh, Bo Hwa Sohn, Seon Rang Woo, Moonkyoo Kong, Deok Hwa Nam, Hee-Jin Jang, Hyun-Sung Lee, Shumei Song, Sang Cheul Oh, Jeeyun Lee, Jaffer A. Ajani, Ju-Seog Lee
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-17 (2023)
Abstract Gastric adenocarcinoma (GAC) is a lethal disease characterized by genomic and clinical heterogeneity. By integrating 8 previously established genomic signatures for GAC subtypes, we identified 6 clinically and molecularly distinct genomic co
Externí odkaz:
https://doaj.org/article/ccfad52390c4482ca6467186cf9c2361
Autor:
Kohei Yamashita, Matheus Sewastjanow-Silva, Katsuhiro Yoshimura, Jane E. Rogers, Ernesto Rosa Vicentini, Melissa Pool Pizzi, Yibo Fan, Gengyi Zou, Jenny J. Li, Mariela Blum Murphy, Qiong Gan, Rebecca E. Waters, Linghua Wang, Jaffer A. Ajani
Publikováno v:
Cancers, Vol 16, Iss 7, p 1300 (2024)
Background: The clinical impact of SMARCA4 mutations (SMARCA4ms) in gastroesophageal adenocarcinoma (GEA) remains underexplored. This study aimed to examine the association of SMARCA4ms with clinical outcomes and co-occurrence with other gene mutatio
Externí odkaz:
https://doaj.org/article/0754bfcb45ad464ca8052df7fb8fbcef
Autor:
Matheus Sewastjanow-Silva, Lianchun Xiao, Graciela N. Gonzalez, Xuemei Wang, Wayne Hofstetter, Stephen Swisher, Reza Mehran, Boris Sepesi, Manoop S. Bhutani, Brian Weston, Emmanuel Coronel, Rebecca E. Waters, Jane E. Rogers, Jackie Smith, Larry Lyons, Norelle Reilly, James C. Yao, Jaffer A. Ajani, Mariela Blum Murphy
Publikováno v:
Cancers, Vol 16, Iss 7, p 1378 (2024)
Efforts to improve the prognosis for patients with locally advanced esophageal or gastroesophageal junction (GEJ) adenocarcinoma have focused on neoadjuvant approaches to increase the pathological complete response (pathCR) rate, improve surgical res
Externí odkaz:
https://doaj.org/article/533a2850c2104c17ba949fc273f9c1c0
Autor:
Henry Hiep Vo, Siqing Fu, David S. Hong, Daniel D. Karp, Sarina Piha-Paul, Vivek Subbiah, Filip Janku, Aung Naing, Timothy A. Yap, Jordi Rodon, Jaffer A. Ajani, Carrie Cartwright, Amber Johnson, I-Wen Song, Jennifer Beck, Michael Kahle, Graciela M. Nogueras-Gonzalez, Vincent Miller, Calvin Chao, David J. Vining, Donald A. Berry, Funda Meric-Bernstam, Apostolia-Maria Tsimberidou
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-12 (2022)
Abstract We investigated the challenges of conducting IMPACT2, an ongoing randomized study that evaluates molecular testing and targeted therapy (ClinicalTrials.gov: NCT02152254). Patients with metastatic cancer underwent tumor profiling and were ran
Externí odkaz:
https://doaj.org/article/0dcfdec9f8b24bf8a8a6b4c9cca14e08
Autor:
Yuan Li, Yibo Fan, Jinbang Xu, Longfei Huo, Ailing W. Scott, Jiankang Jin, Boxuan Yang, Shan Shao, Lang Ma, Ying Wang, Xiaodan Yao, Melissa Pool Pizzi, Matheus Sewastjanow Da Silva, Guoliang Zhang, Lijuan Zhuo, Eun Jeong Cho, Kevin N. Dalby, Namita D. Shanbhag, Zhenning Wang, Wenliang Li, Shumei Song, Jaffer A. Ajani
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background G protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved drugs. GPCR-kinase 3 (GRK3) is critical for GPCR signaling. Our genomic analysis showed that GRK3 expression correlated with poor prognosis
Externí odkaz:
https://doaj.org/article/3cd78adee87548d4bda7f07c29d428ff
Autor:
Shuangtao Zhao, Ruiping Wang, Shumei Song, Dapeng Hao, Guangchun Han, Xingzhi Song, Jianhua Zhang, Melissa Pool Pizzi, Namita Shanbhag, Andrew Futreal, Brian Badgwell, Kazuto Harada, George Calin, Jody Vykoukal, Chuan-Yih Yu, Hiroyuki Katayama, Samir M. Hanash, Linghua Wang, Jaffer A. Ajani
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106913- (2023)
Summary: Advanced gastric adenocarcinoma (GAC) often leads to peritoneal carcinomatosis (PC) and is associated with very poor outcome. Here we report the comprehensive proteogenomic study of ascites derived cells from a prospective GAC cohort (n = 26
Externí odkaz:
https://doaj.org/article/92771087ebd44c8caa6645a8bda153bd
Autor:
Jiankang Jin, Longfei Huo, Yibo Fan, Ruiping Wang, Ailing W. Scott, Melissa Pool Pizzi, Xiaodan Yao, Shan Shao, Lang Ma, Matheus S. Da Silva, Kohei Yamashita, Katsuhiro Yoshimura, Boyu Zhang, Jingjing Wu, Linghua Wang, Shumei Song, Jaffer A. Ajani
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
PurposeTo establish a fast and accurate detection method for interspecies contaminations in the patient-derived xenograft (PDX) models and cell lines, and to elucidate possible mechanisms if interspecies oncogenic transformation is detected.MethodsA
Externí odkaz:
https://doaj.org/article/7e04724fa37e414c86f3a2001fed6319
Autor:
Yuki Hirata, Yi-Ju Chiang, Jeannelyn S. Estrella, Prajnan Das, Bruce D. Minsky, Mariela Blum Murphy, Jaffer A. Ajani, Paul Mansfield, Brian D. Badgwell, Naruhiko Ikoma
Publikováno v:
Cancers, Vol 15, Iss 21, p 5137 (2023)
In gastroesophageal junction (GEJ) adenocarcinoma cases, a prognosis based on ypTNM staging could be affected by preoperative therapy. Patients with esophageal adenocarcinoma and gastric adenocarcinoma who underwent preoperative therapy followed by s
Externí odkaz:
https://doaj.org/article/9a72164c1d50405bb4bd3086df78ef04
Publikováno v:
Cancers, Vol 15, Iss 17, p 4352 (2023)
We discuss the importance of the in vivo models in elucidating cancer biology, focusing on the patient-derived xenograft (PDX) models, which are classic and standard functional in vivo platforms for preclinical evaluation. We provide an overview of t
Externí odkaz:
https://doaj.org/article/1dbc2f152d7a4468aed8eb24d154bb0c