Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jaeyeaon Cho"'
Publikováno v:
Theranostics. 12:2758-2772
The advent of human pluripotent stem cells (hPSCs) presented a new paradigm to employ hPSC-derived cardiomyocytes (hPSC-CMs) in drug screening and disease modeling. However, hPSC-CMs differentiated in conventional two-dimensional systems are structur
Autor:
Hong Yi, Min Goo Lee, Sangsung Kim, Yoshiaki Tanaka, Hun-Jun Park, Kyuwon Cho, Young Sup Yoon, Patrick Tae Joon Hwang, Mark A. Sussman, Seongho Bae, Jaeyeaon Cho, Ho-Wook Jun, Richard P. Harvey, In-Hyun Park, Hee Cheol Cho, Eric Shin, Rebecca D. Levit, Ji Woong Han, Woongchan Rah, Jae kyung Jung, Hyein Lee, Sang Wook Lee, Nam Kyun Kim, Dong Hoon Shin
Publikováno v:
Nat Biomed Eng
Fibroblasts can be directly reprogrammed into cardiomyocytes, endothelial cells or smooth muscle cells. Here, we report the reprogramming of mouse tail-tip fibroblasts simultaneously into cells resembling these three cell types via the microRNA-mimic
Publikováno v:
Circulation Research. 125
Background: Direct reprogramming of fibroblasts into cardiomyocytes (CMs), endothelial cells (ECs), or smooth muscle cells (SMCs) has emerged as a promising strategy for cell-based therapy. Moreover, tissue engineering has become a crucial means to e
Autor:
Akihiro Shirakabe, Shin Ichi Oka, Santosh Bhat, Maha Abdellatif, Peiyong Zhai, Fan Tang, Shohei Ikeda, Chiao Po Hsu, Junco S. Warren, Gopal J. Babu, Jaemin Byun, Yimin Tian, Adave Chin, Guersom Ralda, Yoshiyuki Ikeda, Danish Sayed, Jaeyeaon Cho, Junichi Sadoshima, Kevin Schesing
Publikováno v:
Circulation: Heart Failure. 12
Background: Proper dynamics of RNA polymerase II, such as promoter recruitment and elongation, are essential for transcription. PGC-1α (peroxisome proliferator-activated receptor [PPAR]-γ coactivator-1α), also termed PPARGC1a, is a transcriptional
Autor:
Duojia Pan, Junichi Sadoshima, Jaeyeaon Cho, Takanobu Yamamoto, Norikazu Yabuta, Noritsugu Nakano, Hiroshi Nojima, Yanfei Yang, Peiyong Zhai, Nailing Zhang, Dominic P. Del Re
Publikováno v:
Journal of Biological Chemistry. 288:3977-3988
Yap1 is an important regulator of cardiomyocyte proliferation and embryonic heart development, yet the function of endogenous Yap1 in the adult heart remains unknown. We studied the role of Yap1 in maintaining basal cardiac function and in modulating
Autor:
Peiyong Zhai, Junichi Sadoshima, Ji Yeon Park, Ralph R. Alcendor, Jaeyeaon Cho, Bin Tian, Shinichi Oka, Takanobu Yamamoto, Dan Shao
Publikováno v:
Cell Metabolism. 14:598-611
SummaryHigh energy production in mitochondria is essential for maintaining cardiac contraction in the heart. Genes regulating mitochondrial function are commonly downregulated during heart failure. Here we show that both PPARα and Sirt1 are upregula
Publikováno v:
Journal of Biological Chemistry. 284:36647-36658
The signaling mechanisms facilitating cardiomyocyte (CM) differentiation from bone marrow (BM)-derived mesenchymal stem cells (MSCs) are not well understood. 5-Azacytidine (5-Aza), a DNA demethylating agent, induces expression of cardiac-specific gen
Autor:
Ji Yeon Park, Yasuhiro Maejima, Jaeyeaon Cho, Daniela Zablocki, Chull Hong, David J. Glass, Jayashree Pain, Junichi Sadoshima, Bin Tian, Soichiro Usui
Publikováno v:
Circulation research. 109(2)
Rationale: Overexpression of muscle atrophy F-box (MAFbx/atrogin-1), an E3 ubiquitin ligase, induces proteasomal degradation in cardiomyocytes. The role of endogenous MAFbx in regulating cardiac hypertrophy and failure remains unclear. Objective: We
Publikováno v:
Circulation research. 108(4)
Rationale: Glycogen synthase kinase (GSK)-3β upregulates cardiac genes in bone marrow–derived mesenchymal stem cells (MSCs) in vitro. Ex vivo modification of signaling mechanisms in MSCs may improve the efficiency of cardiac cell-based therapy (CB
Publikováno v:
Circulation. 118
Glycogen synthase kinase 3β (GSK-3β) induces expression of cardiac markers in mesenchymal stem cells (MSCs). We examined whether injection of ex vivo -modified GSK-3β overexpressing MSCs improves cardiac dysfunction after myocardial infarction (MI