Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Jaewhan, Song"'
Autor:
Hyunjin Rho, Seungyeon Kim, Seung Up Kim, Jeong Won Kim, Sang Hoon Lee, Sang Hoon Park, Freddy E. Escorcia, Joon-Yong Chung, Jaewhan Song
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The fusion of autophagosomes and lysosomes is essential for the prevention of nonalcoholic fatty liver disease (NAFLD). Here, we generate a hepatocyte-specific CHIP knockout (H-KO) mouse model that develops NAFLD more rapidly in response to
Externí odkaz:
https://doaj.org/article/573e31edc2d4481182f28e9252d147b2
Autor:
Soohyun Lee, Hwa‐Ryeon Kim, Yaejin Woo, Jiyoung Kim, Han Wool Kim, Ji Youn Park, Beomseon Suh, Yuri Choi, Jungmin Ahn, Je Ho Ryu, Jae‐Seok Roe, Jaewhan Song, Song Hee Lee
Publikováno v:
Advanced Science, Vol 11, Iss 33, Pp n/a-n/a (2024)
Abstract The androgen receptor (AR) is an attractive target for treating prostate cancer, considering its role in the development and progression of localized and metastatic prostate cancer. The high global mortality burden of prostate cancer, despit
Externí odkaz:
https://doaj.org/article/ea8b9935704f4b0aa6c3e1d10cdfe09a
Autor:
Hyunjin Rho, Seungyeon Kim, Seung Up Kim, Jeong Won Kim, Sang Hoon Lee, Sang Hoon Park, Freddy E. Escorcia, Joon-Yong Chung, Jaewhan Song
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/484c9bf01b4b426fa26d4565e852bce6
Autor:
Yeaji Kim, Dong Young Kim, Haiying Zhang, Cho-Rong Bae, Daehyeon Seong, Yeomyung Kim, Jaewhan Song, Young-Myeong Kim, Young-Guen Kwon
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background In sprouting angiogenesis, VEGFR2 level is regulated via a fine-tuned process involving various signaling pathways. Other than VEGF/VEGFR2 signaling pathway, Wnt/ β-catenin signaling is also important in vascular development. How
Externí odkaz:
https://doaj.org/article/e1644512cab04655ab92d3a67dfdc93c
Autor:
Jaewhan Song
Publikováno v:
Clinical and Molecular Hepatology, Vol 26, Iss 4, Pp 484-486 (2020)
Externí odkaz:
https://doaj.org/article/d7fe13e868a64c4888fcae03dbed72ff
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3)
Externí odkaz:
https://doaj.org/article/5ee8c3c1d0c74fad8221aab47d481fd8
Publikováno v:
Cell Stress, Vol 2, Iss 11, Pp 325-328 (2018)
The 5′ adenosine monophosphate-activated protein kinase (AMPK) is an essential energy sensor in the cell, which, at low energy levels, instigates the cellular energy-generating systems along with suppression of the anabolic signaling pathways. The
Externí odkaz:
https://doaj.org/article/af9504de178b46d9850a1783158d5439
Autor:
Min-Sik Lee, Hyun-Ji Han, Su Yeon Han, Il Young Kim, Sehyun Chae, Choong-Sil Lee, Sung Eun Kim, Seul Gi Yoon, Jun-Won Park, Jung-Hoon Kim, Soyeon Shin, Manhyung Jeong, Aram Ko, Ho-Young Lee, Kyoung-Jin Oh, Yun-Hee Lee, Kwang-Hee Bae, Seung-Hoi Koo, Jea-woo Kim, Je Kyung Seong, Daehee Hwang, Jaewhan Song
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
AMPK activation has been suggested as treatment for obesity and its complications. Here the authors show that the ubiquitin ligase MKRN1 binds to AMPK and mediates its ubiquitination and degradation. Loss of MKRN1 leads to AMPK activation, increased
Externí odkaz:
https://doaj.org/article/808f9e7ecce2423aa60cf5a7715788c6
Autor:
Min-Sik Lee, Man-Hyung Jeong, Hyun-Woo Lee, Hyun-Ji Han, Aram Ko, Stephen M. Hewitt, Jae-Hoon Kim, Kyung-Hee Chun, Joon-Yong Chung, Cheolju Lee, Hanbyoul Cho, Jaewhan Song
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-2 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20178-0
Externí odkaz:
https://doaj.org/article/78363281717f4b268322dcae94f71229
Autor:
Sunmi Lee, Joo Young Lee, Eun Woo Lee, Sujin Park, Dong Hoon Kang, Chengchun Min, Doo Jae Lee, Dongmin Kang, Jaewhan Song, Jongbum Kwon, Sang Won Kang
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2194-2211.e6 (2019)
Summary: There are abundant peroxiredoxin (Prx) enzymes, but an increase of cellular H2O2 level always happens in apoptotic cells. Here, we show that cellular H2O2 switches different apoptosis pathways depending on which type of Prx enzyme is absent.
Externí odkaz:
https://doaj.org/article/0b1dc2c617ed4fe580f7c5529366cc78