Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jaeline E. Spowart"'
Publikováno v:
International Journal of Cell Biology, Vol 2012 (2012)
Accumulating evidence indicates that therapies designed to trigger apoptosis in tumor cells cause mitochondrial depolarization, nuclear damage, and the accumulation of misfolded protein aggregates, resulting in the activation of selective forms of au
Externí odkaz:
https://doaj.org/article/180367eaef8f46cc8279934c7f0ee30b
Publikováno v:
International Journal of Cell Biology, Vol 2011 (2011)
Hypoxia is a signature feature of growing tumors. This cellular state creates an inhospitable condition that impedes the growth and function of all cells within the immediate and surrounding tumor microenvironment. To adapt to hypoxia, cells activate
Externí odkaz:
https://doaj.org/article/e3b28313b8e24ddea220038aed65aee4
Autor:
Jeffrey D. Winkler, Julian J. Lum, Anna V. Tinker, Samuel M. Levi, Michael S. Anglesio, Paul Kim, Lindsay DeVorkin, David G. Huntsman, Jenna Ries, Ravi K. Amaravadi, Jaeline E. Spowart, Matthew Hattersley
Publikováno v:
Molecular Cancer Research. 15:250-258
Clear cell ovarian carcinoma (CCOC) is an aggressive form of epithelial ovarian cancer that exhibits low response rates to systemic therapy and poor patient outcomes. Multiple studies in CCOC have revealed expression profiles consistent with increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af1f917304778704ff676e270bd9d37
https://doi.org/10.1158/1541-7786.mcr-16-0132
https://doi.org/10.1158/1541-7786.mcr-16-0132
Autor:
Michael S. Anglesio, Sharon M. Gorski, Julian J. Lum, Jaeline E. Spowart, Katelin N. Townsend, Nathan R. West, Sima Eshragh, C. Blake Gilks, David G. Huntsman, Peter H. Watson, Jenna N Ries, Hassan Huwait, Steve E. Kalloger
Publikováno v:
The Journal of Pathology. 228:437-447
Clear cell ovarian cancer histotypes exhibit metabolic features associated with resistance to hypoxia and glucose deprivation-induced cell death. This metabolic characteristic suggests that clear cell ovarian cancers activate survival mechanisms not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::342c919ce60cfa5ae3fb8d32c3c21009
https://doi.org/10.1002/path.4090
https://doi.org/10.1002/path.4090
Publikováno v:
International Journal of Cell Biology, Vol 2012 (2012)
International Journal of Cell Biology
International Journal of Cell Biology
Accumulating evidence indicates that therapies designed to trigger apoptosis in tumor cells cause mitochondrial depolarization, nuclear damage, and the accumulation of misfolded protein aggregates, resulting in the activation of selective forms of au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bee6f08e5f2e4ed3765fa4171877cc3
https://doi.org/10.1155/2012/872091
https://doi.org/10.1155/2012/872091
Publikováno v:
International Journal of Cell Biology
International Journal of Cell Biology, Vol 2011 (2011)
International Journal of Cell Biology, Vol 2011 (2011)
Hypoxia is a signature feature of growing tumors. This cellular state creates an inhospitable condition that impedes the growth and function of all cells within the immediate and surrounding tumor microenvironment. To adapt to hypoxia, cells activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75d4addd2497db3ae2a0c982f8b91e9
https://doi.org/10.1155/2011/470597
https://doi.org/10.1155/2011/470597
Autor:
Katelin N. Townsend, Jaeline E. Spowart, Nathan R. West, Julian J. Lum, Hassan Huwait, Michael S. Anglesio, Peter H. Watson, David G. Huntsman, Steve E. Kalloger, Sima Eshragh, Mary A. Elrick
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82406 (2013)
PLoS ONE
PLoS ONE
Background When T cells infiltrate the tumor environment they encounter a myriad of metabolic stressors including hypoxia. Overcoming the limitations imposed by an inadequate tumor vasculature that contributes to these stressors may be a crucial step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adfe00efb77b2a813afd7fb0c42836f
http://europepmc.org/articles/PMC3871161?pdf=render
http://europepmc.org/articles/PMC3871161?pdf=render
Autor:
Jaeline E, Spowart, Katelin N, Townsend, Hassan, Huwait, Sima, Eshragh, Nathan R, West, Jenna N, Ries, Steve, Kalloger, Michael, Anglesio, Sharon M, Gorski, Peter H, Watson, C Blake, Gilks, David G, Huntsman, Julian J, Lum
Publikováno v:
The Journal of pathology. 228(4)
Clear cell ovarian cancer histotypes exhibit metabolic features associated with resistance to hypoxia and glucose deprivation-induced cell death. This metabolic characteristic suggests that clear cell ovarian cancers activate survival mechanisms not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f816444e64d7917e59cfd81b460b2337
https://pubmed.ncbi.nlm.nih.gov/22951989
https://pubmed.ncbi.nlm.nih.gov/22951989
Autor:
Julian J. Lum, Jaeline E. Spowart
Publikováno v:
EMBO reports. 11:4-5
Despite a significant body of literature identifying the main regulators of autophagy in model organisms, there are gaps in our understanding of the precise molecular and biochemical modulators that control this adaptive process in metazoans. Two stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb17b4983d8ed488c74254092a57045
https://doi.org/10.1038/embor.2009.265
https://doi.org/10.1038/embor.2009.265