Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Jaeki Min"'
Autor:
Seung Wook Yang, Xin Huang, Wenwei Lin, Jaeki Min, Darcie J. Miller, Anand Mayasundari, Patrick Rodrigues, Elizabeth C. Griffith, Clifford T. Gee, Lei Li, Wei Li, Richard E. Lee, Zoran Rankovic, Taosheng Chen, Patrick Ryan Potts
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Testis-restricted melanoma antigen (MAGE) proteins function as substrate adapters for E3 ubiquitin ligases. Biochemical and structural analyses of MAGE-A11 provide insight into the substrate binding mode of MAGE proteins and enable discovery of poten
Externí odkaz:
https://doaj.org/article/b277e39e14d144a186f5155bc60329ef
Autor:
Diana Ortiz, W Armand Guiguemde, Jared T Hammill, Angela K Carrillo, Yizhe Chen, Michele Connelly, Kayla Stalheim, Carolyn Elya, Alex Johnson, Jaeki Min, Anang Shelat, David C Smithson, Lei Yang, Fangyi Zhu, R Kiplin Guy, Scott M Landfear
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 12, p e0006157 (2017)
Leishmaniasis is a parasitic infection that afflicts approximately 12 million people worldwide. There are several limitations to the approved drug therapies for leishmaniasis, including moderate to severe toxicity, growing drug resistance, and the ne
Externí odkaz:
https://doaj.org/article/fd582fbd68d94e90b34293f3995c292e
Autor:
Mariell Pettersson, David Bliman, Jimmy Jacobsson, Jesper R Nilsson, Jaeki Min, Luigi Iconaru, R Kiplin Guy, Richard W Kriwacki, Joakim Andréasson, Morten Grøtli
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124423 (2015)
Small molecule nonpeptidic mimics of α-helices are widely recognised as protein-protein interaction (PPIs) inhibitors. Protein-protein interactions mediate virtually all important regulatory pathways in a cell, and the ability to control and modulat
Externí odkaz:
https://doaj.org/article/6029b62f2cd9436aa042c3db3168a3cb
Autor:
Diana Ortiz, W Armand Guiguemde, Alex Johnson, Carolyn Elya, Johanna Anderson, Julie Clark, Michele Connelly, Lei Yang, Jaeki Min, Yuko Sato, R Kiplin Guy, Scott M Landfear
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123598 (2015)
Development of resistance against current antimalarial drugs necessitates the search for novel drugs that interact with different targets and have distinct mechanisms of action. Malaria parasites depend upon high levels of glucose uptake followed by
Externí odkaz:
https://doaj.org/article/3157b6287d2b423eb876d7995bd2c64e
Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction.
Autor:
Mariell Pettersson, Maria Quant, Jaeki Min, Luigi Iconaru, Richard W Kriwacki, M Brett Waddell, R Kiplin Guy, Kristina Luthman, Morten Grøtli
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0137867 (2015)
The transcription factor p53 is the main tumour suppressor in cells and many cancer types have p53 mutations resulting in a loss of its function. In tumours that retain wild-type p53 function, p53 activity is down-regulated by MDM2 (human murine doub
Externí odkaz:
https://doaj.org/article/005ed7b47b1e46878acb025bd57235f1
Autor:
Michal Bista, David Smithson, Aleksandra Pecak, Gabriella Salinas, Katarzyna Pustelny, Jaeki Min, Artur Pirog, Kristin Finch, Michal Zdzalik, Brett Waddell, Benedykt Wladyka, Sylwia Kedracka-Krok, Michael A Dyer, Grzegorz Dubin, R Kiplin Guy
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37518 (2012)
SJ-172550 (1) was previously discovered in a biochemical high throughput screen for inhibitors of the interaction of MDMX and p53 and characterized as a reversible inhibitor (J. Biol. Chem. 2010; 285:10786). Further study of the biochemical mode of a
Externí odkaz:
https://doaj.org/article/50c3d2a731444c08bd0b42fc618a17eb
Publikováno v:
RSC Chemical Biology. 4:192-215
This review surveys molecular glue-induced ternary complexes in the PDB and provides an overview of computational methods that can be utilized to predict them.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4b0635f737c896fa8a1481c80acde7d
https://doi.org/10.1039/d2cb00207h
https://doi.org/10.1039/d2cb00207h
Autor:
Barbara Jonchere, Justin Williams, Frederique Zindy, Jingjing Liu, Sarah Robinson, Dana M. Farmer, Jaeki Min, Lei Yang, Jennifer L. Stripay, Yingzhe Wang, Burgess B. Freeman, Jiyang Yu, Anang A. Shelat, Zoran Rankovic, Martine F. Roussel
Publikováno v:
Mol Cancer Ther
Despite improvement in the treatment of medulloblastoma over the last years, numerous patients with MYC- and MYCN-driven tumors still fail current therapies. Medulloblastomas have an intact retinoblastoma protein RB, suggesting that CDK4/6 inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23757531488e8d14390795beee04cc01
https://doi.org/10.1158/1535-7163.mct-21-0896
https://doi.org/10.1158/1535-7163.mct-21-0896
Autor:
Giovanni Quarato, Fabien Llambi, Cliff S. Guy, Jaeki Min, Marisa Actis, Huan Sun, Shilpa Narina, Shondra M. Pruett-Miller, Junmin Peng, Zoran Rankovic, Douglas R. Green
Publikováno v:
Cell Death Differ
The ability of mitochondria to buffer a rapid rise in cytosolic Ca(2+) is a hallmark of proper cell homeostasis. Here, we employed m-3M3FBS, a putative phospholipase C (PLC) agonist, to explore the relationships between intracellular Ca(2+) imbalance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab54d66980d55325eacebf630dd38416
https://doi.org/10.1038/s41418-022-01025-9
https://doi.org/10.1038/s41418-022-01025-9
Autor:
Martine F. Roussel, Zoran Rankovic, Anang A. Shelat, Jiyang Yu, Burgess B. Freeman, Yingzhe Wang, Jennifer L. Stripay, Lei Yang, Jaeki Min, Dana M. Farmer, Sarah Robinson, Jingjing Liu, Frederique Zindy, Justin Williams, Barbara Jonchere
Supplementary Table S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236f806a25294382e5dbce7fc1ee4813
https://doi.org/10.1158/1535-7163.22523529.v1
https://doi.org/10.1158/1535-7163.22523529.v1
