Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly

Autor: Sanghwa Lee, Jonghyeok Shin, Younghun Jung, Heyjin Son, Jaeil Shin, Cherlhyun Jeong, Dae-Hyuk Kweon, Yeon-Kyun Shin

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)

Abstract In neuronal exocytosis, SNARE assembly into a stable four-helix bundle drives membrane fusion. Previous studies have revealed that the SM protein Munc18-1 plays a critical role for precise SNARE assembly with the help of Munc13-1, but the un

Externí odkaz: https://doaj.org/article/9b8cf37ff71545a589930604bb4e66e8

Neurological, Psychiatric, and Psychological Implications of the COVID-19 Pandemic: Protocol for a Large-Scale Umbrella Review of Observational Studies

Autor: Ta-Chuan Yeh, Chih-Sung Liang, Chia-Kuang Tsai, Marco Solmi, Beny Lafer, Ping-Tao Tseng, Chih-Wei Hsu, Pao-Yen Lin, Joseph Firth, Brendon Stubbs, Lamiece Hassan, Michele Fornaro, Eduard Vieta, Trevor Thompson, Jaeil Shin, Andre F. Carvalho

Publikováno v: Yeh, T-C, Liang, C-S, Tsai, C-K, Solmi, M, Lafer, B, Tseng, P-T, Hsu, C-W, Lin, P-Y, Firth, J, Stubbs, B, Hassan, L, Fornaro, M, Vieta, E, Thompson, T, Shin, J I & Carvalho, A F 2022, ' Neurological, Psychiatric, and Psychological Implications of the COVID-19 Pandemic: Protocol for a Large-Scale Umbrella Review of Observational Studies ', International Journal of Environmental Research and Public Health, vol. 19, no. 3, 1681, pp. e1681 . https://doi.org/10.3390/ijerph19031681
International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, Vol 19, Iss 1681, p 1681 (2022)
Dipòsit Digital de la UB
Universidad de Barcelona
Yeh, T C, Liang, C S, Tsai, C K, Solmi, M, Lafer, B, Tseng, P T, Hsu, C W, Lin, P Y, Firth, J, Stubbs, B, Hassan, L, Fornaro, M, Vieta, E, Thompson, T, Shin, J I & Carvalho, A F 2022, ' Neurological, Psychiatric, and Psychological Implications of the COVID-19 Pandemic : Protocol for a Large-Scale Umbrella Review of Observational Studies ', International Journal of Environmental Research and Public Health, vol. 19, no. 3, 1681 . https://doi.org/10.3390/ijerph19031681

The severe acute respiratory syndrome coronavirus 2 disease (SARS-CoV-2) is the most severe manifestation of the coronavirus disease 2019 (COVID-19) pandemic. Accruing evidence indicates that the COVID-19 pandemic may have profound deleterious neurol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59cdfafa856e4627fa4a2efb44cfadb
https://doi.org/10.3390/ijerph19031681

Synaptotagmin-1 Is an Antagonist for Munc18-1 in SNARE Zippering

Autor: Yeon-Kyun Shin, Jaewook Kim, Yoosoo Yang, Jaeil Shin, Xiaochu Lou

Publikováno v: Journal of Biological Chemistry. 290:10535-10543

In neuroexocytosis, SNAREs and Munc18-1 may consist of the minimal membrane fusion machinery. Consistent with this notion, we observed, using single molecule fluorescence assays, that Munc18-1 stimulates SNARE zippering and SNARE-dependent lipid mixi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5804beb9995bf742d76cc190f733643f
https://doi.org/10.1074/jbc.m114.631341

Abstract LB-206: The synergistic antitumor effect of the combination of three transgenes delivered by the oncolytic vaccinia virus, KLS-3020

Autor: Jaeil Shin, Soon-Oh Hong, Minjung Kim, Heonsik Choi, Sujeong Kim

Publikováno v: Cancer Research. 79:LB-206

Oncolytic viruses that selectively kill cancer cells are a promising platform for fighting cancer. Vaccinia virus is a good candidate for the oncolytic virus because it has several advantages such as a proven safety profile, broad host tropism, and l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::775f025d73741adab1a8d217622d9d9b
https://doi.org/10.1158/1538-7445.am2019-lb-206

A Chemical Controller of SNARE-Driven Membrane Fusion That Primes Vesicles for Ca(2+)-Triggered Millisecond Exocytosis

Autor: Yeon-Kyun Shin, Jonghyeok Shin, Taekjip Ha, Dae-Hyuk Kweon, Jaeil Shin, Young Hoon Jung, Paul Heo, Byoungjae Kong, Cherlhyun Jeong, Kyu Young Han, Yoosoo Yang

Publikováno v: Journal of the American Chemical Society. 138(13)

Membrane fusion is mediated by the SNARE complex which is formed through a zippering process. Here, we developed a chemical controller for the progress of membrane fusion. A hemifusion state was arrested by a polyphenol myricetin which binds to the S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dc498e48f15cb48f68422a310fabf2
https://pubmed.ncbi.nlm.nih.gov/26987363