Výsledky vyhledávání

Akademický článek

Genome-wide CRISPR screening identifies tyrosylprotein sulfotransferase-2 as a target for augmenting anti-PD1 efficacy

Publikováno v: Molecular Cancer, Vol 23, Iss 1, Pp 1-19 (2024)

Abstract Background Immune checkpoint therapy (ICT) provides durable responses in select cancer patients, yet resistance remains a significant challenge, prompting the exploration of underlying molecular mechanisms. Tyrosylprotein sulfotransferase-2

Externí odkaz: https://doaj.org/article/47974d639c9a4312819824b9409e4268

Zobrazit plný text záznamu

Akademický článek

Direct cell-to-cell transfer in stressed tumor microenvironment aggravates tumorigenic or metastatic potential in pancreatic cancer

Autor: Giyong Jang, Jaeik Oh, Eunsung Jun, Jieun Lee, Jee Young Kwon, Jaesang Kim, Sang-Hyuk Lee, Song Cheol Kim, Sung-Yup Cho, Charles Lee

Publikováno v: npj Genomic Medicine, Vol 7, Iss 1, Pp 1-17 (2022)

Abstract Pancreatic cancer exhibits a characteristic tumor microenvironment (TME) due to enhanced fibrosis and hypoxia and is particularly resistant to conventional chemotherapy. However, the molecular mechanisms underlying TME-associated treatment r

Externí odkaz: https://doaj.org/article/6c31f188376b4aa5ae9c2cfd740cb169

Zobrazit plný text záznamu

Gut bacteria-derived 3-phenylpropionylglycine mitigates adipocyte differentiation of 3T3-L1 cells by inhibiting adiponectin-PPAR pathway

Autor: Hae Rim Jung, Yumi Oh, Dongjun Jang, Seungjae Shin, Soo-Jin Lee, Jiwon Kim, Sang Eun Lee, Jaeik Oh, Giyong Jang, Obin Kwon, Yeonmi Lee, Hui-Young Lee, Sung-Yup Cho

Publikováno v: Genesgenomics. 45(1)

Gut microbiota provide numerous types of metabolites that humans cannot produce and have a huge influence on the host metabolism. Accordingly, gut bacteria-derived metabolites can be employed as a resource to develop anti-obesity and metabolism-modul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6097aef7719e4d6ab539a6991dafdb6
https://pubmed.ncbi.nlm.nih.gov/36434390

Zobrazit plný text záznamu

Abstract 3716: RNA N6-methyladenosine binding protein, YTHDF1 regulates DNA repair and cancer immunity in protein synthesis levels

Autor: Dongjun Jang, Hae Rim Jung, Jaeik Oh, Sung-Yup Cho

Publikováno v: Cancer Research. 83:3716-3716

N6-methyladenosine RNA methylation is one of the most abundant post transcriptional modifications in eukaryotic messenger RNAs and plays crucial roles in cancer development and progression. YTHDF1 is an m6A reader protein and has been reported to inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5062177c52563f184ea48345eb8fcf6
https://doi.org/10.1158/1538-7445.am2023-3716

Zobrazit plný text záznamu

Augmentation of the RNA m6A reader signature is associated with poor survival by enhancing cell proliferation and EMT across cancer types

Autor: Jaeik Oh, Chanwoong Hwa, Dongjun Jang, Seungjae Shin, Soo-Jin Lee, Jiwon Kim, Sang Eun Lee, Hae Rim Jung, Yumi Oh, Giyong Jang, Obin Kwon, Joon-Yong An, Sung-Yup Cho

Publikováno v: Experimentalmolecular medicine. 54(7)

N6-Methyladenosine (m6A) RNA modification plays a critical role in the posttranscriptional regulation of gene expression. Alterations in cellular m6A levels and m6A-related genes have been reported in many cancers, but whether they play oncogenic or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18958c8f50a6d9e20eaa12fbd91adf28
https://pubmed.ncbi.nlm.nih.gov/35794212

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání