Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jaegwon Chung"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Microglia play a critical role in maintaining brain homeostasis but become dysregulated in neurodegenerative diseases. Regulator of G-protein Signaling 10 (RGS10), one of the most abundant homeostasis proteins in microglia, decreases with aging and f
Externí odkaz:
https://doaj.org/article/6b7916ebb4054de5bb6d2b501dca8f66
Autor:
Kelly B. Menees, Rachael H. Earls, Jaegwon Chung, Janna Jernigan, Nikolay M. Filipov, Jessica M. Carpenter, Jae-Kyung Lee
Publikováno v:
Immunity & Ageing, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background Physiological homeostasis decline, immunosenescence, and increased risk for multiple diseases, including neurodegeneration, are all hallmarks of ageing. Importantly, it is known that the ageing process is sex-biased. For example,
Externí odkaz:
https://doaj.org/article/5d941ca1cc154dc19e710e3142783f80
Autor:
Rachael H. Earls, Kelly B. Menees, Jaegwon Chung, James Barber, Claire-Anne Gutekunst, Manuel G. Hazim, Jae-Kyung Lee
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Parkinson’s disease (PD) is characterized by the accumulation of alpha-synuclein (α-syn) inclusions, the major component of Lewy bodies. Extracellular α-syn aggregates act as a damage-associated molecular pattern (DAMP) and the presence
Externí odkaz:
https://doaj.org/article/05bb54c44a8d4ced913f1027e33cbea1
Autor:
Lori N. Eidson, George T. Kannarkat, Christopher J. Barnum, Jianjun Chang, Jaegwon Chung, Chelsea Caspell-Garcia, Peggy Taylor, Brit Mollenhauer, Michael G. Schlossmacher, Larry Ereshefsky, Mark Yen, Catherine Kopil, Mark Frasier, Kenneth Marek, Vicki S. Hertzberg, Malú G. Tansey
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-16 (2017)
Abstract Background Efforts to identify fluid biomarkers of Parkinson’s disease (PD) have intensified in the last decade. As the role of inflammation in PD pathophysiology becomes increasingly recognized, investigators aim to define inflammatory si
Externí odkaz:
https://doaj.org/article/4759130fbf4b43dfb829cdfe656a57b3
Critical role of regulator G-protein signaling 10 (RGS10) in modulating macrophage M1/M2 activation.
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81785 (2013)
Regulator of G protein signaling 10 (RGS10), a GTPase accelerating protein (GAP) for G alpha subunits, is a negative regulator of NF-κB in microglia. Here, we investigated the role of RGS10 in macrophages, a closely related myeloid-derived cell type
Externí odkaz:
https://doaj.org/article/ea99784166514d88945257448f8114bf
Autor:
Jaegwon Chung, Hea Jin Park, Jae-Kyung Lee, Julie Jeon, Rachael H. Earls, Isabelle Snider, Erik Olsen, Xi Fang
Publikováno v:
Nutrition Research. 70:50-59
The interaction between insulin resistance and inflammation plays a central role in the development of chronic diseases, although the mechanism is not fully understood. We previously demonstrated that regulator of G-protein signaling-10 (RGS10) prote
Autor:
Nikolay M. Filipov, Rachael H. Earls, Jae-Kyung Lee, Jaegwon Chung, Janna Jernigan, Jessica M. Carpenter, Kelly B. Menees
Publikováno v:
Immunity & Ageing, Vol 18, Iss 1, Pp 1-13 (2021)
Immunity & Ageing : I & A
Immunity & Ageing : I & A
Background Physiological homeostasis decline, immunosenescence, and increased risk for multiple diseases, including neurodegeneration, are all hallmarks of ageing. Importantly, it is known that the ageing process is sex-biased. For example, there are
Autor:
Jun Ming Li, Lauren A. Jeffers, Soojung Lee, Yejin Kim, Carlos Gonzalez-Islas, Sadie E. Nennig, Jaegwon Chung, Jae-Kyung Lee, Zhe Jin, Jianjun Chang, Ebbe Boedtkjer, Inyeong Choi, Hannah D. Fulenwider, Christian Aalkjaer, Jesse R. Schank
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Schank, J R, Lee, S, Gonzalez-Islas, C E, Nennig, S E, Fulenwider, H D, Chang, J, Li, J M, Kim, Y, Jeffers, L A, Chung, J, Lee, J-K, Jin, Z, Aalkjær, C, Boedtkjer, E & Choi, I 2020, ' Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1 ', Scientific Reports, vol. 10, no. 1, 11017 . https://doi.org/10.1038/s41598-020-67291-0
Scientific Reports
Schank, J R, Lee, S, Gonzalez-Islas, C E, Nennig, S E, Fulenwider, H D, Chang, J, Li, J M, Kim, Y, Jeffers, L A, Chung, J, Lee, J-K, Jin, Z, Aalkjær, C, Boedtkjer, E & Choi, I 2020, ' Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1 ', Scientific Reports, vol. 10, no. 1, 11017 . https://doi.org/10.1038/s41598-020-67291-0
Scientific Reports
The previous reports on an addiction vulnerability marker in the human SLC4A7 gene encoding the Na/HCO3 transporter NBCn1 suggest that this pH-regulating protein may affect alcohol-related behavior and response. Here, we examined alcohol consumption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca542b242805b68dde33f0e0fe904f2
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419699
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419699
Autor:
James Barber, Jaegwon Chung, Claire-Anne Gutekunst, Rachael H. Earls, Jae-Kyung Lee, Kelly B. Menees, Manuel G. Hazim
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Parkinson’s disease (PD) is characterized by the accumulation of alpha-synuclein (α-syn) inclusions, the major component of Lewy bodies. Extracellular α-syn aggregates act as a damage-associated molecular pattern (DAMP) and the presence of autoan
Autor:
Kennie R. Shepherd, Jae-Kyung Lee, Jianjun Chang, Chenere P. Ramsey, Isadora Porter, Malú G. Tansey, Jaegwon Chung, Danielle Oliver, George T. Kannarkat
Publikováno v:
Neurobiology of Aging. 36:1982-1993
Inflammation in the aging brain increases risk for neurodegenerative disease. In humans, the Regulator of G-protein Signaling (RGS) 10 locus has been associated with age-related maculopathy. Chronic peripheral administration of lipopolysaccharide in