Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Jaechan Leem"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 4, Pp 3470-3483 (2024)
Atopic dermatitis (AD), marked by intense itching and eczema-like lesions, is a globally increasing chronic skin inflammation. Kahweol, a diterpene that naturally occurs in coffee beans, boasts anti-inflammatory, antioxidative, and anti-cancer proper
Externí odkaz:
https://doaj.org/article/45c04e6ec00747ef864dcba831eda026
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e30908- (2024)
The histone acetyltransferase p300 plays a pivotal role in regulating gene expression and cellular phenotype through epigenetic mechanisms. It significantly influences lipid metabolism, which is a key factor in the pathogenesis of non-alcoholic steat
Externí odkaz:
https://doaj.org/article/33599602b18044e6bf09635e5a83690b
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 9, Pp 7027-7042 (2023)
Acute kidney injury (AKI) is a common complication of sepsis. Eupatilin (EUP) is a natural flavone with multiple biological activities and has beneficial effects against various inflammatory disorders. However, whether EUP has a favorable effect on s
Externí odkaz:
https://doaj.org/article/f33def4feffc4ccca51520f0c891456f
Publikováno v:
Molecules, Vol 29, Iss 12, p 2881 (2024)
Cisplatin, a platinum-based chemotherapeutic, is effective against various solid tumors, but its use is often limited by its nephrotoxic effects. This study evaluated the protective effects of trametinib, an FDA-approved selective inhibitor of mitoge
Externí odkaz:
https://doaj.org/article/d9894aacf5ff429085cdd20b35bfe1e5
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 5, Pp 4389-4399 (2023)
Acetaminophen (APAP) overdose can cause severe liver damage, but therapeutic options are limited. Apamin is a natural peptide present in bee venom and has antioxidant and anti-inflammatory properties. Accumulating evidence suggests that apamin has fa
Externí odkaz:
https://doaj.org/article/ce3f3c5d2a6c4ffa9ef0f2834a525528
Autor:
Mi-Gyeong Gwon, Jaechan Leem, Hyun-Jin An, Hyemin Gu, Seongjae Bae, Jong Hyun Kim, Kwan-Kyu Park
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102036- (2023)
Atopic dermatitis (AD) is a common inflammatory skin disease caused by an immune disorder. Mast cells are known to be activated and granulated to maintain an allergic reaction, including rhinitis, asthma, and AD. Although hypoxia-inducible factor-1 a
Externí odkaz:
https://doaj.org/article/8fa66ff47c004a729309793f16b22a9f
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 1, Pp 337-352 (2023)
Obstructive uropathy is a clinical condition that can lead to chronic kidney disease. However, treatments that can prevent the progression of renal injury and fibrosis are limited. Farrerol (FA) is a natural flavone with potent antioxidant and anti-i
Externí odkaz:
https://doaj.org/article/d4f0dc0ae1454a38bb1d4e7e07748b16
Publikováno v:
Molecules, Vol 29, Iss 2, p 419 (2024)
Non-alcoholic steatohepatitis (NASH) is becoming an increasingly serious global health threat, distinguished by hepatic lipid accumulation, inflammation, and fibrosis. There is a lack of approved pharmaceutical interventions for this disease, highlig
Externí odkaz:
https://doaj.org/article/9fdfe01acf4043f58755b7a6dd7c7270
Publikováno v:
Molecules, Vol 28, Iss 6, p 2759 (2023)
Sepsis is a severe inflammatory condition that can cause organ dysfunction, including acute kidney injury (AKI). Hesperetin is a flavonoid aglycone that has potent antioxidant and anti-inflammatory properties. However, the effect of hesperetin on sep
Externí odkaz:
https://doaj.org/article/df24d183c92c45988f3096653254a9db
Publikováno v:
Antioxidants, Vol 11, Iss 12, p 2341 (2022)
Renal fibrosis is a common feature of chronic kidney disease and is a promising therapeutic target. However, there is still limited treatment for renal fibrosis, so the development of new anti-fibrotic agents is urgently needed. Accumulating evidence
Externí odkaz:
https://doaj.org/article/d7176046cd8c47a7b9d86ac2c707cfd6