Zobrazeno 1 - 10
of 283
pro vyhledávání: '"Jae-Sung BAE"'
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 2, Pp 301-310 (2024)
Abstract Over the past decade, numerous studies have highlighted the importance of acid sphingomyelinase (ASM) in disease treatment in humans. This enzyme functions primarily to generate ceramide, maintain the cellular membrane, and regulate cellular
Externí odkaz:
https://doaj.org/article/cb4a2933386c45fe81edf0e0a655241c
Autor:
Sanjeeb Shrestha, Yu-Bin Lee, Hoyul Lee, Yeon-Kyung Choi, Bo-Yoon Park, Mi-Jin Kim, Young-Jin Youn, Sun-Hwa Kim, Soo-Jung Jung, Dong-Keun Song, Hee Kyung Jin, Jae-Sung Bae, In-Kyu Lee, Jae-Han Jeon, Chang-Won Hong
Publikováno v:
Research, Vol 7 (2024)
Neutrophils are primed for neutrophil extracellular trap (NET) formation during diabetes, and excessive NET formation from primed neutrophils compromises wound healing in patients with diabetes. Here, we demonstrate that trained immunity mediates dia
Externí odkaz:
https://doaj.org/article/fa6f59cb501b4c1fa9b33d82f542279e
Autor:
Byung Jo Choi, Min Hee Park, Kang Ho Park, Wan Hui Han, Hee Ji Yoon, Hye Yoon Jung, Ju Yeon Hong, Md Riad Chowdhury, Kyung Yeol Kim, Jihoon Lee, Im-Sook Song, Minyeong Pang, Min-Koo Choi, Erich Gulbins, Martin Reichel, Johannes Kornhuber, Chang-Won Hong, Changho Kim, Seung Hyun Kim, Edward H. Schuchman, Hee Kyung Jin, Jae-sung Bae
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Acid sphingomyelinase (ASM) is a sphingolipid metabolizing enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide, and previous work has shown it is upregulated in models of Alzheimer’s disease. Here the authors demonstrate in a mouse mo
Externí odkaz:
https://doaj.org/article/52c99cf51ae64f39b52ec19ee7f53cf4
Autor:
Hyeon Jun Jeon, MyeongJae Kang, Joon Seok Lee, Jieun Kang, Eun A. Kim, Hee Kyung Jin, Jae-sung Bae, Jung Dug Yang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Although capsular contracture remains one of the major problems following silicone breast implantation, the associated mechanism has yet to be determined. This study thus aimed to investigate capsule formation and capsular contracture using
Externí odkaz:
https://doaj.org/article/2fe22d2ceffa45609a7dc9555514ccbc
Autor:
Jun-Kyu Kim, Young-Jin Youn, Yu-Bin Lee, Sun-Hwa Kim, Dong-Keun Song, Minsang Shin, Hee Kyung Jin, Jae-sung Bae, Sanjeeb Shrestha, Chang-Won Hong
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Extracellular vesicles (EVs) are membrane-derived heterogeneous vesicles that mediate intercellular communications. They have recently been considered as ideal vehicles for drug-delivery systems, and immune cells are suggested as a potential
Externí odkaz:
https://doaj.org/article/49ad586bf1c545759c45dcf051fef806
Autor:
Ju Youn Lee, Seung Hoon Han, Min Hee Park, Im-Sook Song, Min-Koo Choi, Eunsoo Yu, Cheol-Min Park, Hee-Jin Kim, Seung Hyun Kim, Edward H. Schuchman, Hee Kyung Jin, Jae-sung Bae
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Neuronal sphingosine kinase 1 (SphK1) acetylates COX2 which is needed for microglial phagocytosis activity, and release of pro-resolving mediators (SPMs) from neurons. Here the authors examine how SphK1-mediates COX2 acetylation, and how this leads t
Externí odkaz:
https://doaj.org/article/3035df8592594ac98f3be370c56a59d8
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 3, Pp 380-389 (2020)
Age-related neurodegenerative diseases: role of enzyme crucial to membrane function Targeting a critical enzyme involved in the metabolism of cellular membrane molecules could help treat age-related neurodegenerative diseases. Aging is a key risk fac
Externí odkaz:
https://doaj.org/article/c83739d0e4604ace88f605bf29c188de
Publikováno v:
Animal Cells and Systems, Vol 23, Iss 5, Pp 346-354 (2019)
Niemann-Pick type C disease (NP-C) is a fatal neurodegenerative disorder caused by a deficiency in the function of the NPC1 gene. Malfunction of this gene/protein leads to progressive accumulation of unesterified cholesterol and sphingolipids in many
Externí odkaz:
https://doaj.org/article/b46cefa8b897497e9ebdbb6daa37a354
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 1956 (2022)
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and is associated with several pathophysiological features, including cellular dysfunction, failure of neurotransmission, cognitive impairment, cell death, and other clinical c
Externí odkaz:
https://doaj.org/article/789a931045c44d1a997ce7640b1069a0
Publikováno v:
Animal Cells and Systems, Vol 22, Iss 5, Pp 281-288 (2018)
Chemotherapy-induced bone marrow damage is accompanied by acute nerve injury in the bone marrow (BM), resulting in sensory and autonomic neuropathy. Cisplatin, a popular chemotherapy drugs, induces the impairment of hematopoietic stem cells (HSCs) an
Externí odkaz:
https://doaj.org/article/eb3d3f22ce0f4b6e9fda74f835a134a8