Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jae-Sun Ra"'
Autor:
Scisung Chung, Mi-Sun Kang, Dauren S. Alimbetov, Gil-Im Mun, Na-Oh Yunn, Yunjin Kim, Byung-Gyu Kim, Minwoo Wie, Eun A. Lee, Jae Sun Ra, Jung-Min Oh, Donghyun Lee, Keondo Lee, Jihan Kim, Seung Hyun Han, Kyong-Tai Kim, Wan Kyun Chung, Ki Hyun Nam, Jaehyun Park, ByungHoon Lee, Sunghoon Kim, Weixing Zhao, Sung Ho Ryu, Yun-Sil Lee, Kyungjae Myung, Yunje Cho
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Aminoacyl-tRNA synthetases possess unique domains. In this study the structure of the vertebrate IARS1 and EARS1 complex reveals that vertebrate IARS1 protects the DNA repair factor BRCA1 from proteolytic degradation via its UBX-fold domain.
Externí odkaz:
https://doaj.org/article/3a702a1ed24a45f995d55ea263c1b376
Autor:
Kibeom Park, Hee‐Seop Yoo, Chang‐Kyu Oh, Joo Rak Lee, Hee Jin Chung, Ha‐Neul Kim, Soo‐Hyun Kim, Kyung‐Mi Kee, Tong Yoon Kim, Myungshin Kim, Byung‐Gyu Kim, Jae Sun Ra, Kyungjae Myung, Hongtae Kim, Seung Hun Han, Min‐Duk Seo, Yoonsung Lee, Dong‐Wook Kim
Publikováno v:
Cancer Medicine, Vol 11, Iss 21, Pp 4005-4020 (2022)
Abstract Cobll1 affects blast crisis (BC) progression and tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML). PACSIN2, a novel Cobll1 binding protein, activates TKI‐induced apoptosis in K562 cells, and this activation is s
Externí odkaz:
https://doaj.org/article/b46d4d333a56496f9e49e9161fbe2a8e
Autor:
Su Hyung Park, Nalae Kang, Eunho Song, Minwoo Wie, Eun A. Lee, Sunyoung Hwang, Deokjae Lee, Jae Sun Ra, In Bae Park, Jieun Park, Sukhyun Kang, Jun Hong Park, Sungchul Hohng, Kyoo-young Lee, Kyungjae Myung
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
How the replisome machinery contributes to fork stability under replication stress is currently not clear. Here the authors reveal a role for ATAD5 in maintaining genome integrity during replication stress by promoting replication restart through RAD
Externí odkaz:
https://doaj.org/article/4ac4913c149c4dd78292e37f24a832b8
Autor:
Hyun Je Kang, Hyun Park, Eun Jin Yoo, Jun Ho Lee, Soo Youn Choi, Whaseon Lee-Kwon, Kyoo-young Lee, Jin-Hoe Hur, Jeong Kon Seo, Jae Sun Ra, Eun-A. Lee, Kyungjae Myung, Hyug Moo Kwon
Publikováno v:
iScience, Vol 19, Iss , Pp 177-190 (2019)
Summary: Polyubiquitination of proliferating cell nuclear antigen (PCNA) regulates the error-free template-switching mechanism for the bypass of DNA lesions during DNA replication. PCNA polyubiquitination is critical for the maintenance of genomic in
Externí odkaz:
https://doaj.org/article/14a94c35bac0452abc34bf283bd79d85
Autor:
Mi-Sun Kang, Eunjin Ryu, Seung-Won Lee, Jieun Park, Na Young Ha, Jae Sun Ra, Yeong Jae Kim, Jinwoo Kim, Mohamed Abdel-Rahman, Su Hyung Park, Kyoo-young Lee, Hajin Kim, Sukhyun Kang, Kyungjae Myung
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). Here authors use biochemical and single molecule measurements to show that ATAD5-RLC has the most potent PCNA unlo
Externí odkaz:
https://doaj.org/article/96cbddeb94864108881d91854ff5ff84
Autor:
Geunil Yi, Yubin Sung, Chanwoo Kim, Jae Sun Ra, Hirokazu Hirakawa, Takamitsu A Kato, Akira Fujimori, Hajin Kim, Kei-ichi Takata
Publikováno v:
Nucleic Acids Research. 51:2257-2269
DNA polymerase θ (POLQ) is a unique DNA polymerase that is able to perform microhomology-mediated end-joining as well as translesion synthesis (TLS) across an abasic (AP) site and thymine glycol (Tg). However, the biological significance of the TLS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd961f6c8e239a7626f0c702b3c3ab5d
https://doi.org/10.1093/nar/gkad076
https://doi.org/10.1093/nar/gkad076
Autor:
Hee Jin Chung, Joo Rak Lee, Tae Moon Kim, Soomi Kim, Kibeom Park, Myung-Jin Kim, Eunyoung Jung, Subin Kim, Eun A Lee, Jae Sun Ra, Sunyoung Hwang, Ja Yil Lee, Orlando D Schärer, Yonghwan Kim, Kyungjae Myung, Hongtae Kim
Publikováno v:
Nucleic Acids Research. 51:631-649
TRAIP is a key factor involved in the DNA damage response (DDR), homologous recombination (HR) and DNA interstrand crosslink (ICL) repair. However, the exact functions of TRAIP in these processes in mammalian cells are not fully understood. Here we i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8920f21b8e5baa69624b2f6b7cadbcbd
https://doi.org/10.1093/nar/gkac1226
https://doi.org/10.1093/nar/gkac1226
Autor:
Mi-Sun Kang, Jinwoo Kim, Eunjin Ryu, Na Young Ha, Sunyoung Hwang, Byung-Gyu Kim, Jae Sun Ra, Yeong Jae Kim, Jung Me Hwang, Kyungjae Myung, Sukhyun Kang
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4632-4645.e5 (2019)
Summary: Proliferating cell nuclear antigen (PCNA) is a DNA clamp essential for DNA replication. During DNA synthesis, PCNA is continuously loaded onto and unloaded from DNA. PCNA recruits various proteins to nascent DNA to facilitate chromosome dupl
Externí odkaz:
https://doaj.org/article/0f62caf6fe144f1589b75e22fa0c8c42
Autor:
Jung-Min Oh, Yujin Kang, Jumi Park, Yubin Sung, Dayoung Kim, Yuri Seo, Eun A Lee, Jae Sun Ra, Enkhzul Amarsanaa, Young-Un Park, Seon Young Lee, Jung Me Hwang, Hongtae Kim, Orlando Schärer, Seung Woo Cho, Changwook Lee, Kei-ichi Takata, Ja Yil Lee, Kyungjae Myung
Publikováno v:
Nucleic Acids Research.
DNA double-strand break (DSB) repair via homologous recombination is initiated by end resection. The extent of DNA end resection determines the choice of the DSB repair pathway. Nucleases for end resection have been extensively studied. However, it i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e4872204eb805556eb09dc000ad1582
https://doi.org/10.1093/nar/gkad308
https://doi.org/10.1093/nar/gkad308
Autor:
Minwoo Wie, Keon Woo Khim, Groehler IV, Arnold S., Soomin Heo, Junhyeok Woo, Kook Son, Lee, Eun A., Jae Sun Ra, Sung You Hong, Schärer, Orlando D., Jang Hyun Choi, Kyungjae Myung
Publikováno v:
NAR Cancer; Sep2023, Vol. 5 Issue 3, p1-14, 14p