Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jae-Kyu Jung"'
Autor:
Michelle Solomon, Lars Thoresen, Robert M. Jones, Andrew J. Grottick, David J. Unett, Abu J.M. Sadeque, Chuan Chen, Ibragim Gaidarov, Hussien A. Al-Shamma, Jayant Thatte, Graeme Semple, Jae-Kyu Jung, Amin Usmani, Jeremy Barden, Xiuwen Zhu, Woo Hyun Yoon, Sangdon Han, Christopher Ronald J
Publikováno v:
ACS Medicinal Chemistry Letters. 8:1309-1313
The discovery of a novel, selective and fully efficacious CB2 agonist with satisfactory pharmacokinetic and pharmaceutical properties is described. Compound 6 was efficacious in a rat model of osteoarthritis pain following oral administration and, in
Autor:
Hussien A. Al-Shamma, Michael Morgan, Ibragim Gaidarov, Huong T. Dang, Joel Gatlin, Marc Decaire, David J. Unett, Karoline Choi, Jeff Edwards, Dawei Yue, Abu J.M. Sadeque, Kevin Whelan, Yifeng Xiong, Lixia Fu, Jayant Thatte, Graeme Semple, Sonja Strah-Pleynet, Sangdon Han, Michelle Solomon, Dominic P. Behan, Jae-Kyu Jung, Sanju Narayanan, Lars Thoresen, Robert M. Jones, Chuan Chen, Xiuwen Zhu, Khawja A. Usmani, Cameron Pride, Ruoping Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:322-326
The design and synthesis of novel 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamide CB2 selective ligands for the potential treatment of pain is described. Compound (R,R)-25 has good balance between CB2 agonist potency and selecti
Autor:
Jerry Xu, Milton L. Hammond, Brett Lauring, James R. Tata, Philip J. Skinner, Jens Knudsen, Daniel T. Connolly, Eseng Lai, Graeme Semple, Wen-Lin Luo, M. Gerard Waters, P. Douglas Boatman, John A. Wagner, Martin C. Cherrier, Jae-Kyu Jung, Steven L. Colletti, Andrew K.P. Taggart, Ester Carballo-Jane, Ruoping Chen, Benjamin R. Johnson, Thomas O. Schrader, Josee Cote, Carleton R. Sage, Luzelena Caro, Jeremy G. Richman, Michelle Kasem, Peter J. Webb
Publikováno v:
Journal of Medicinal Chemistry. 55:3644-3666
G-protein coupled receptor (GPCR) GPR109a is a molecular target for nicotinic acid and is expressed in adipocytes, spleen, and immune cells. Nicotinic acid has long been used for the treatment of dyslipidemia due to its capacity to positively affect
Autor:
Andrew K.P. Taggart, Abby Smenton, Steven L. Colletti, Scott Tria, Subharekha Raghavan, Sookhee Chang, M. Gerard Waters, Darby Schmidt, James R. Tata, Thomas O. Schrader, Rui Liang, Jae-Kyu Jung, Craig K. Esser, Jason E. Imbriglio, Kang Cheng, Ester Carballo-Jane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2121-2124
5-Alkyl and aryl-pyrazole–tetrazoles have been identified as a new class of selective, small-molecule, agonists of the human G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid.
Publikováno v:
Tetrahedron. 57:283-296
Oxidative cyclization of bis-hydroxynaphthyl ethers allows concise total syntheses of palmarumycin CP 1 and deoxypreussomerin A in 8-9 steps and 15–35% overall yield from 5-hydroxy-8-methoxy-1-tetralone ( 8 ). Polymer-bound triphenyl phosphine was
Autor:
Jason E. Imbriglio, Michael Wolff, Andrew K.P. Taggart, Abby Smenton, Subharekha Raghavan, Rui Liang, Scott Tria, Sookhee Chang, Tom G. Holt, Kang Cheng, Ester Carballo-Jane, Craig K. Esser, James R. Tata, Darby Schmidt, Thomas O. Schrader, M. Gerard Waters, Jae-Kyu Jung, Steven L. Colletti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4472-4474
5-Alkyl and aryl-pyrazole-acids have been identified as a new class of selective, small-molecule, agonists of the human orphan G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid.
Autor:
Jae-Kyu Jung, Peter Wipf
Publikováno v:
Angewandte Chemie International Edition in English. 36:764-767
Autor:
Jae-Kyu Jung, Peter Wipf
Publikováno v:
ChemInform. 29
Autor:
Jae-Kyu Jung, Peter Wipf
Publikováno v:
ChemInform. 30
Autor:
Peter Wipf, Jae-Kyu Jung
Publikováno v:
ChemInform. 30