Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Jae-Hyuck Shim"'
Autor:
Afreen Anwar, Taruneet Kaur, Sachin Chaugule, Yeon-Suk Yang, Aryan Mago, Jae-Hyuck Shim, Aijaz Ahmad John
Publikováno v:
Sensors, Vol 24, Iss 19, p 6172 (2024)
Osteoporosis, a prevalent ailment worldwide, compromises bone strength and resilience, particularly afflicting the elderly population. This condition significantly heightens susceptibility to fractures even from trivial incidents, such as minor falls
Externí odkaz:
https://doaj.org/article/4c50a236ca7242c3b4d931443ca739d0
Autor:
Yeon-Suk Yang, Tadatoshi Sato, Sachin Chaugule, Hong Ma, Jun Xie, Guangping Gao, Jae-Hyuck Shim
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102111- (2024)
Osteogenesis imperfecta (OI) is a genetic disorder characterized by bone fragility, low bone mass, fractures, and extraskeletal manifestations. Since OI is commonly caused by single-nucleotide mutation(s) in the COL1A1 or COL1A2 genes encoding type I
Externí odkaz:
https://doaj.org/article/ec898dcefb954a6485808c098630bb89
Autor:
Chujiao Lin, Qiyuan Yang, Dongsheng Guo, Jun Xie, Yeon-Suk Yang, Sachin Chaugule, Ngoc DeSouza, Won-Taek Oh, Rui Li, Zhihao Chen, Aijaz A. John, Qiang Qiu, Lihua Julie Zhu, Matthew B. Greenblatt, Sankar Ghosh, Shaoguang Li, Guangping Gao, Cole Haynes, Charles P. Emerson, Jae-Hyuck Shim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Skeletal progenitors provide a reservoir for bone-forming osteoblasts. However, the major energy source for their osteogenesis remains unresolved. Here, the authors demonstrate that ESCIT-mediated regulation of mitochondrial metabolism is required fo
Externí odkaz:
https://doaj.org/article/7ba9a8c0d31344639b3d19b6b3e7140e
Autor:
Yeon-Suk Yang, Jung-Min Kim, Jun Xie, Sachin Chaugule, Chujiao Lin, Hong Ma, Edward Hsiao, Jaehyoung Hong, Hyonho Chun, Eileen M. Shore, Frederick S. Kaplan, Guangping Gao, Jae-Hyuck Shim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Fibrodysplasia ossificans progressiva is an ultra-rare genetic disorder with progressive heterotopic ossification. Yang et al develop different gene therapy approaches and show their efficacy in mouse models and in human induced pluripotent stem cell
Externí odkaz:
https://doaj.org/article/261d337857a4449b8131eb048cff41f6
Autor:
Aijaz Ahmad John, Jun Xie, Yeon-Suk Yang, Jung-Min Kim, Chujiao Lin, Hong Ma, Guangping Gao, Jae-Hyuck Shim
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 296-311 (2022)
Osteoporosis occurs due to a dysregulation in bone remodeling, a process requiring both bone-forming osteoblasts and bone-resorbing osteoclasts. Current leading osteoporosis therapies suppress osteoclast-mediated bone resorption but show limited ther
Externí odkaz:
https://doaj.org/article/6a863fcf948c40ecacdf2bebc2956fdb
Autor:
Yeon-Suk Yang, Chujiao Lin, Hong Ma, Jun Xie, Frederick S. Kaplan, Guangping Gao, Jae-Hyuck Shim
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1364 (2023)
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by progressive disabling heterotopic ossification (HO) at extra-skeletal sites. Here, we developed adeno-associated virus (AAV)-based gene therapy that suppre
Externí odkaz:
https://doaj.org/article/40696c78b90643a9a83c19fbbdd827bd
Publikováno v:
Sensors, Vol 23, Iss 18, p 7904 (2023)
Chronic exposure to low concentrations of volatile organic compounds (VOCs), such as chlorobenzene, is not being monitored in industrializing countries, although VOC exposure is associated with carcinogenic, organ-toxic, and endocrine-disrupting effe
Externí odkaz:
https://doaj.org/article/20f66a44c4374cbfad501baf079691c2
Autor:
Jun Sun, Dong Yeon Shin, Mark Eiseman, Alisha R. Yallowitz, Na Li, Sarfaraz Lalani, Zan Li, Michelle Cung, Seoyeon Bok, Shawon Debnath, Sofia Jenia Marquez, Tommy E. White, Abdul G. Khan, Ivo C. Lorenz, Jae-Hyuck Shim, Francis S. Lee, Ren Xu, Matthew B. Greenblatt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Hedgehog signaling is essential for bone formation. Here, the authors show that the transmembrane protein SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts, suggesting it may be a potential therapeutic target to enhance bone format
Externí odkaz:
https://doaj.org/article/336539fea16c45a5b002c405f1af2ce5
Autor:
Jung-Min Kim, Yeon-Suk Yang, Jaehyoung Hong, Sachin Chaugule, Hyonho Chun, Marjolein CH van der Meulen, Ren Xu, Matthew B Greenblatt, Jae-hyuck Shim
Publikováno v:
eLife, Vol 11 (2022)
Emerging evidence supports that osteogenic differentiation of skeletal progenitors is a key determinant of overall bone formation and bone mass. Despite extensive studies showing the function of mitogen-activated protein kinases (MAPKs) in osteoblast
Externí odkaz:
https://doaj.org/article/435d9b2fd74c49e8a18463a57619a847
Autor:
Seoyeon Bok, Dong Yeon Shin, Alisha R. Yallowitz, Mark Eiseman, Michelle Cung, Ren Xu, Na Li, Jun Sun, Alfred L. Williams, John E. Scott, Bing Su, Jae-Hyuck Shim, Matthew B. Greenblatt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Neurofibromatosis type I (NF1) is characterized by prominent skeletal abnormalities mediated in part by aberrant ERK pathway activation due to NF1 loss-of-function. Here, the authors report the MEKK2 is a key mediator of this aberrant ERK activation
Externí odkaz:
https://doaj.org/article/1bdc5e8883dd407b82aab19c4cfb975b