Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Jae-Ha Ryu"'
Autor:
Jin-Kyoung Shim, Seung Hoon Lim, Ji Hye Jeong, Ran Joo Choi, Yoojung Oh, Junseong Park, Sunghee Choi, Junpyo Hong, Seo Jin Kim, Ju Hyung Moon, Eui Hyun Kim, Wan-Yee Teo, Bong Jin Park, Jong Hee Chang, Jae-Ha Ryu, Seok-Gu Kang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Forkhead Box M1 (FOXM1) is known to regulate cell proliferation, apoptosis and tumorigenesis. The lignan, (−)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol (DFS), from Alnus japonica has shown anti-cancer effects against colon cancer cells
Externí odkaz:
https://doaj.org/article/252a5f0689a94714b6f6b4d7ca9e3c69
Autor:
Hyejin Lee, Kyeong Seon Lee, Ji Hye Jeong, Ji Soo Yoon, Seung Hwan Hwang, Sang-Yoon Kim, Sung Hum Yeon, Jae-Ha Ryu
Publikováno v:
Journal of Functional Foods, Vol 101, Iss , Pp 105419- (2023)
As part of our effort to search for food ingredients with ability to inhibit muscle wasting, we found that extract of Alnus japonica (AJE) and its main constituent, oregonin, could prevent muscle atrophy from in vitro and in vivo studies. Oregonin ri
Externí odkaz:
https://doaj.org/article/e2c8e8e1bad249dda8b81a2d40895049
Publikováno v:
Animal Cells and Systems, Vol 0, Iss 0, Pp 1-9 (2022)
Autophagy modulators are considered putative therapeutic targets because of the role of autophagy in cancer progression. Kazinol C, a 1,3-diphenylpropane from the plant Broussonetia kazinoki, has been shown to induce apoptosis in colon cancer cells t
Externí odkaz:
https://doaj.org/article/9479d1d5b53e4e929865254cf0ac7807
Anti-pancreatic cancer activity of Z-ajoene from garlic: An inhibitor of the Hedgehog/Gli/FoxM1 axis
Publikováno v:
Journal of Functional Foods, Vol 56, Iss , Pp 102-109 (2019)
Overexpression of glioma-associated oncogene (Gli), a transcription factor at the final step of Hedgehog (Hh) pathway, is involved in pancreatic cancer development. Therefore, inhibition of Gli can be a therapeutic strategy to treat pancreatic cancer
Externí odkaz:
https://doaj.org/article/2e4950ad9019409ebe9fd58c85173ac7
Autor:
Eun Lee, Hyewon Cho, Da Kyung Lee, JuHyun Ha, Byeong Jo Choi, Ji Hye Jeong, Jae-Ha Ryu, Jong Soon Kang, Raok Jeon
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8006 (2020)
As a member of the tyrosine protein kinase Tec (TEC) family, Bruton’s tyrosine kinase (BTK) is considered a promising therapeutic target due to its crucial roles in the B cell receptor (BCR) signaling pathway. Although many types of BTK inhibitors
Externí odkaz:
https://doaj.org/article/0661d0cce498486391e8279374c65d6f
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 7919 (2020)
Bruton’s tyrosine kinase (BTK) is an attractive target for treating patients with B cell malignancies and autoimmune diseases. Many BTK inhibitors have been identified; however, like other kinase inhibitors, they lack diversity in their core struct
Externí odkaz:
https://doaj.org/article/f1cb4fd4638642ce889dda7ad872d386
Publikováno v:
Molecules, Vol 25, Iss 15, p 3346 (2020)
In the present study, we isolated a lignan ((−)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol, DFS) from Alnus japonica and evaluated its antiobesity potential in vitro. We also determined its mechanism of action in a mouse pre-adipocyte 3T3-L1 cell
Externí odkaz:
https://doaj.org/article/4c7bbd72725349c9b17a2f3f4ae033cd
Autor:
Ji Hye Jeong, Jae-Ha Ryu
Publikováno v:
Molecules, Vol 25, Iss 10, p 2328 (2020)
Pancreatic cancer has a high mortality rate due to poor rates of early diagnosis. One tumor suppressor gene in particular, p53, is frequently mutated in pancreatic cancer, and mutations in p53 can inactivate normal wild type p53 activity and increase
Externí odkaz:
https://doaj.org/article/8ad7c55f22b443f39b85c187fc2671b4
Publikováno v:
Molecules, Vol 25, Iss 3, p 703 (2020)
Aberrant activation of a Wnt/β-catenin pathway results in nuclear accumulation of β-catenin in colon cancer. Inhibiting β-catenin is one strategy for treating colon cancer. Here, we identified Z-ajoene, a sulfur containing compound isolated from c
Externí odkaz:
https://doaj.org/article/3afbea92f455420f874c5a4f99223c00
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1571 (2020)
Inflammatory conditions caused by cancer, chronic diseases or aging can lead to skeletal muscle atrophy. We identified myogenic compounds from Psoralea corylifolia (PC), a medicinal plant that has been used for the treatment of inflammatory and skin
Externí odkaz:
https://doaj.org/article/67bb0e9433724cd4afbfac1f7cb50026