Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Jae Young Seong"'
Autor:
Jin Joo Cha, Boo Yeon Park, Sung Gi Yoon, Hye Jin Park, Ji Ae Yoo, Jung Yeon Ghee, Dae Ryong Cha, Jae Young Seong, Young Sun Kang
Publikováno v:
Animal Cells and Systems, Vol 27, Iss 1, Pp 187-196 (2023)
ABSTRACTThe spexin-based GALR2 agonist (NS200) is a novel drug, which has shown antidepressant and anxiolytic action in a recent experimental study. In this study, we investigated the effects of NS200 on renal injury in an animal model of type 2 diab
Externí odkaz:
https://doaj.org/article/b3688d217e9346e4a944dfc9797c6973
Autor:
Lan Phuong Nguyen, Minyeong Cho, Thai Uy Nguyen, Hee-Kyung Park, Huong Thi Nguyen, Kateryna Mykhailova, Sunghoon Hurh, Hong-Rae Kim, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Background Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regulating various physiological processes including neurotransmission, nociception, inflammation, smooth muscle c
Externí odkaz:
https://doaj.org/article/307d7b190b1740099026f1f1d0b3fcd4
Autor:
Hee-Kyung Park, Yun Hee Na, Huong Thi Nguyen, Lan Phuong Nguyen, Sunghoon Hurh, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Background C–C motif chemokine receptor 2 (CCR2), the main receptor for monocyte chemoattractant protein-1 (MCP-1), is expressed on immune cells, including monocytes, macrophages, and activated T cells, and mediates cell migration toward M
Externí odkaz:
https://doaj.org/article/6ac685567ac64321b6b9b2da2d457435
Autor:
Arfaxad Reyes-Alcaraz, Emilio Y. Lucero Garcia-Rojas, Elizabeth A. Merlinsky, Jae Young Seong, Richard A. Bond, Bradley K. McConnell
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
Membrane protein trafficking is monitored using split nanoluciferase. Receptor internalization leads to complementation on the early endosome and a bioluminescent response, and is applied to receptor internalization/recycling, antibody-mediated inter
Externí odkaz:
https://doaj.org/article/887afa516ed4492caceb65547a0547f1
Autor:
Hee-Kyung Park, Lan Phuong Nguyen, Thai Uy Nguyen, Minyeong Cho, Huong Thi Nguyen, Sunghoon Hurh, Hong-Rae Kim, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0283015 (2023)
C-X-C motif chemokine ligand 12(CXCL12) is an essential chemokine for organ development and homeostasis in multiple tissues. Its receptor, C-X-C chemokine receptor type 4(CXCR4), is expressed on the surface of target cells. The chemokine and receptor
Externí odkaz:
https://doaj.org/article/b73cd6734236484ca880e25dfd65c7ba
Autor:
Yoo-Na Lee, Arfaxad Reyes-Alcaraz, Seongsik Yun, Cheol Soon Lee, Jong-Ik Hwang, Jae Young Seong
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230872 (2020)
Galanin receptors (GALRs) belong to the superfamily of G-protein coupled receptors. The three GALR subtypes (GALR1, GALR2, and GALR3) are activated by their endogenous ligands: spexin (SPX) and galanin (GAL). The synthetic SPX-based GALR2-specific ag
Externí odkaz:
https://doaj.org/article/d4b933417a2d421abb6124327be14c8e
Autor:
Anu Shahapal, Eun Bee Cho, Hyo Jeong Yong, Inyoung Jeong, Hoyun Kwak, Jae Keun Lee, Wonkyum Kim, Bongcheol Kim, Hae-Chul Park, Won Suk Lee, Hyun Kim, Jong-Ik Hwang, Jae Young Seong
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
FAM19A5 is a secretory protein that is predominantly expressed in the brain. Although the FAM19A5 gene has been found to be associated with neurological and/or psychiatric diseases, only limited information is available on its function in the brain.
Externí odkaz:
https://doaj.org/article/a5437c09bc414f328b5ff28e19c62391
Publikováno v:
Frontiers in Neural Circuits, Vol 13 (2019)
Spexin (SPX) is an evolutionarily conserved neuropeptide that is expressed in the mammalian brain and peripheral tissue. Two orthologs are present in the teleost, SPX1 and SPX2. SPX1 is involved in reproduction and food intake. Recently, SPX1 neurons
Externí odkaz:
https://doaj.org/article/552901b2999b4e1387a72572f1a4b116
Autor:
Seongsik Yun, Arfaxad Reyes-Alcaraz, Yoo-Na Lee, Hyo Jeong Yong, Jeewon Choi, Byung-Joo Ham, Jong-Woo Sohn, Dong-Hoon Kim, Gi Hoon Son, Hyun Kim, Soon-Gu Kwon, Dong Sik Kim, Bong Chul Kim, Jong-Ik Hwang, Jae Young Seong
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Despite the established comorbidity between mood disorders and abnormal eating behaviors, the underlying molecular mechanism and therapeutics remain to be resolved. Here, we show that a spexin-based galanin receptor type 2 agonist (SG2A) simultaneous
Externí odkaz:
https://doaj.org/article/3bd03b366ad241c68e3ed73f1eea03d4
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 623 (2020)
Peripheral nociceptors and their synaptic partners utilize neuropeptides for signal transmission. Such communication tunes the excitatory and inhibitory function of nociceptor-based circuits, eventually contributing to pain modulation. Corticotropin-
Externí odkaz:
https://doaj.org/article/0d464b0502ee407b818c69b3c74b7ffc