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Radicular Groove Accessory Canal Morphology in Mandibular First Premolars: Micro–computed Tomographic Study

Autor: Mário Pereira, Diogo Guerreiro, Neville J. McDonald, Jae M. Shin

Publikováno v: Journal of Endodontics. 45:554-559

Introduction The purpose of this study was to investigate the morphologic features of radicular groove accessory canals (RGACs) in mandibular first premolars and their relationship to root anatomy by micro–computed tomographic imaging. Methods A to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26892ad1ee16381fc675656cf12e70e0
https://doi.org/10.1016/j.joen.2018.12.017

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Periodontal pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a probiotic bacteriocin

Autor: Richard P. Darveau, Yvonne L. Kapila, Ana Chang, Islam Ateia, Jae M. Shin, Ling Zhan, Pachiyappan Kamarajan, Charles Q. Le, J. Christopher Fenno

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 10, p e1008881 (2020)
PLoS pathogens, vol 16, iss 10

Epidemiological studies reveal significant associations between periodontitis and oral cancer. However, knowledge about the contribution of periodontal pathogens to oral cancer and potential regulatory mechanisms involved is limited. Previously, we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62da0013dde837eaaa38b875b466504
http://europepmc.org/articles/PMC7529280

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High-purity Nisin Alone or in Combination with Sodium Hypochlorite Is Effective against Planktonic and Biofilm Populations of Enterococcus faecalis

Autor: Guo-Hao Lin, J. Christopher Fenno, Jae M. Shin, Ruma Kajwadkar, Alexander H. Rickard, Yvonne L. Kapila

Publikováno v: Journal of Endodontics. 43:989-994

Introduction Nisin, a broad-spectrum bacteriocin, has recently been highlighted for its biomedical applications. To date, no studies have examined the antimicrobial and antibiofilm properties of high-purity (>95%) nisin (nisin ZP) on Enterococcus fae

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2f7c53ce37911236108cbb9afbdef5
https://doi.org/10.1016/j.joen.2017.01.034

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A Modified Shuttle Plasmid Facilitates Expression of a Flavin Mononucleotide-Based Fluorescent Protein in Treponema denticola ATCC 35405

Autor: Jae M. Shin, Alexander H. Rickard, Yvonne L. Kapila, J. Christopher Fenno, M. Paula Goetting-Minesky, Valentina Godovikova

Publikováno v: Applied and Environmental Microbiology. 81:6496-6504

Oral pathogens, including Treponema denticola , initiate the dysregulation of tissue homeostasis that characterizes periodontitis. However, progress of research on the roles of T. denticola in microbe-host interactions and signaling, microbial commun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d81446f922d6332caf574bf841bc57
https://doi.org/10.1128/aem.01541-15

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Deciphering Endodontic Microbial Communities by Next-generation Sequencing

Autor: Tatiana M. Botero, Neville J. McDonald, Kyu Han Lee, Diogo Guerreiro, Alexander H. Rickard, Ting Luo, Jae M. Shin

Publikováno v: Journal of endodontics. 44(7)

Introduction Biofilms are present in more than 70% of endodontically diseased teeth. Through the advancements in the next-generation sequencing (NGS) technologies, microbiome research has granted a deeper analysis of the microbial communities living

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748690bb6508f7c3ff4af5c3448c0ef6
https://pubmed.ncbi.nlm.nih.gov/29861065

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Microbial Communities Associated with Primary and Metastatic Head and Neck Squamous Cell Carcinoma - A High Fusobacterial and Low Streptococcal Signature

Autor: J. Christopher Fenno, Jae M. Shin, Pachiyappan Kamarajan, Alexander H. Rickard, Yvonne L. Kapila, Ting Luo

Publikováno v: Shin, JM; Luo, T; Kamarajan, P; Fenno, JC; Rickard, AH; & Kapila, YL. (2017). Microbial Communities Associated with Primary and Metastatic Head and Neck Squamous Cell Carcinoma-A High Fusobacterial and Low Streptococcal Signature. SCIENTIFIC REPORTS, 7, 9934. doi: 10.1038/s41598-017-09786-x. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4m76q35n
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports

Given the potential relationship between head and neck squamous cell carcinoma (HNSCC) and microbial dysbiosis, we profiled the microbiome within healthy normal and tumorous (primary and metastatic) human tissues from the oral cavity, larynx-pharynx,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267b9a9d67b9673d9141d3eac0d3467b
http://www.escholarship.org/uc/item/4m76q35n

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ADAM17‐mediatedCD44 cleavage promotes orasphere formation or stemness and tumorigenesis inHNSCC

Autor: Jae M. Shin, Yvonne L. Kapila, Pachiyappan Kamarajan, Joey Yizhou Zhu, Xu Qian, Bibiana Matte

Publikováno v: Cancer Medicine

CD44, an extracellular matrix (ECM) receptor, has been described as a cancer stem cell marker in multiple cancers, including head and neck squamous cell carcinoma (HNSCC). HNSCC orasphere formation or stemness was characterized by cleavage of CD44, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02fc5b08caa0def0e7a3ff033bb0800
https://doi.org/10.1002/cam4.147

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Metabolomics of Head and Neck Cancer: A Mini-Review

Autor: Jae M Shin, Pachiyappan Kamarajan, J Christopher Fenno, Alexander Hammond Rickard, Yvonne Lorraine Kapila

Publikováno v: Frontiers in Physiology, Vol 7 (2016)
Frontiers in Physiology

Metabolomics is used in systems biology to enhance the understanding of complex disease processes, such as cancer. Head and neck cancer (HNC) is an epithelial malignancy that arises in the upper aerodigestive tract and affects more than half a millio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baf7475481d5079d5d74bf608bcc829
https://doi.org/10.3389/fphys.2016.00526

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Biomedical Applications of Nisin

Autor: Yvonne L. Kapila, Alexander H. Rickard, J.C. Fenno, J.W. Gwak, Jae M. Shin, Pachiyappan Kamarajan

Publikováno v: Journal of applied microbiology, vol 120, iss 6

Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin is classified as a Type A (I) lantibiotic that is synthesized from mRNA and the translated peptide contains several unus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616d4ff0ef05ad69f49e1ed5d1ad6150
https://europepmc.org/articles/PMC4866897/

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