Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Jae K. Lee"'
Autor:
Suvra Nath, Jose C. Martínez Santamaría, Yu-Hsuan Chu, James S. Choi, Pasquale Conforti, Jia-Di Lin, Roman Sankowski, Lukas Amann, Christos Galanis, Kexin Wu, Sachin S. Deshpande, Andreas Vlachos, Marco Prinz, Jae K. Lee, Christian Schachtrup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract After a stroke, the neurogenic response from the subventricular zone (SVZ) to repair the brain is limited. Microglia, as an integral part of the distinctive SVZ microenvironment, control neural stem / precursor cell (NSPC) behavior. Here, we
Externí odkaz:
https://doaj.org/article/7aaae40ae2e04412a7b85444f8236258
Autor:
Christine B. Ryan, James S. Choi, Brian Kang, Seth Herr, Claudia Pereira, Carlos T. Moraes, Hassan Al-Ali, Jae K. Lee
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106370- (2024)
After spinal cord injury (SCI), infiltrating macrophages undergo excessive phagocytosis of myelin and cellular debris, forming lipid-laden foamy macrophages. To understand their role in the cellular pathology of SCI, investigation of the foamy macrop
Externí odkaz:
https://doaj.org/article/cf44ff5fe6334848bb34adf7fffb39dd
Publikováno v:
Neurobiology of Disease, Vol 163, Iss , Pp 105608- (2022)
Tissue damage after spinal cord injury (SCI) elicits a robust inflammatory cascade that fails to resolve in a timely manner, resulting in impaired wound healing and cellular regeneration. This inflammatory response is partly mediated by infiltrating
Externí odkaz:
https://doaj.org/article/d0757bf957be420da63ec6471c4e376d
Autor:
Clara Penas, Marie E. Maloof, Vasileios Stathias, Jun Long, Sze Kiat Tan, Jose Mier, Yin Fang, Camilo Valdes, Jezabel Rodriguez-Blanco, Cheng-Ming Chiang, David J. Robbins, Daniel J. Liebl, Jae K. Lee, Mary E. Hatten, Jennifer Clarke, Nagi G. Ayad
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The mechanisms controlling irreversible cell cycle exit in cerebellar granule progenitors (GCPs) have not been fully elucidated. Here, the authors performed RNA-sequencing of GCPs exiting the cell cycle to identify downregulation of Brd4 activity as
Externí odkaz:
https://doaj.org/article/5d102d486ad049ca91e993219a553e49
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
The lack of effective treatments for most neurological diseases has prompted the search for novel therapeutic options. Interestingly, neuroinflammation is emerging as a common feature to target in most CNS pathologies. Recent studies suggest that tar
Externí odkaz:
https://doaj.org/article/20677bcdac27479f923445337cf392b1
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Remyelination failure is a crucial component of disease progression in the autoimmune demyelinating disease Multiple Sclerosis (MS). The regenerative capacity of oligodendrocyte progenitor cells (OPCs) to replace myelinating oligodendrocytes is likel
Externí odkaz:
https://doaj.org/article/c3d9ea8e8f254b119c949a8f435fe6c8
Autor:
Haritha L. Desu, Placido Illiano, James S. Choi, Maureen C. Ascona, Han Gao, Jae K. Lee, Roberta Brambilla
Publikováno v:
Cells, Vol 10, Iss 7, p 1785 (2021)
Multiple sclerosis (MS) is a neuroimmune disorder characterized by inflammation, CNS demyelination, and progressive neurodegeneration. Chronic MS patients exhibit impaired remyelination capacity, partly due to the changes that oligodendrocyte precurs
Externí odkaz:
https://doaj.org/article/c82a87df9beb4f83949427dacf3e0f79
Autor:
Le Thi Anh Hong, Young-Min Kim, Hee Hwan Park, Dong Hoon Hwang, Yuexian Cui, Eun Mi Lee, Stephanie Yahn, Jae K. Lee, Soo-Chang Song, Byung Gon Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle. Here the authors show an injection of imidazole poly(organophosphazenes), a hydrogel with thermosensitive sol–gel transition behavior, almost completely
Externí odkaz:
https://doaj.org/article/f1ef677ce24a49e5b92880944ff2a393
Autor:
Jan Poleszczuk, Kimberly Luddy, Lu Chen, Jae K. Lee, Louis B. Harrison, Brian J. Czerniecki, Hatem Soliman, Heiko Enderling
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-7 (2017)
Abstract Background Compared with surgery alone, postoperative adjuvant radiotherapy (RT) improves relapse-free survival of patients with early-stage breast cancer. We evaluated the long-term overall and disease-free survival rates of neoadjuvant (pr
Externí odkaz:
https://doaj.org/article/6ee58a4f455947438309a4c228d54bc2
Autor:
Hye Sook Chon, Sokbom Kang, Jae K. Lee, Sachin M. Apte, Mian M. Shahzad, Irene Williams-Elson, Robert M. Wenham
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017)
Abstract Background Ridaforolimus is a mammalian target of rapamycin inhibitor that has activity in solid tumors. Paclitaxel and carboplatin have broad antineoplastic activity in many cancers. This phase I trial was conducted to determine the safety
Externí odkaz:
https://doaj.org/article/1b109462c15a423c87e4159720107cd7