Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Jae J. Song"'
Publikováno v:
Molecular Therapy: Oncolytics, Vol 27, Iss , Pp 26-47 (2022)
Systemic delivery of oncolytic viruses has been widely regarded as an impractical option for antitumor treatment. Here, we selected two target genes as leading components, and significant therapeutic effects were obtained by simultaneously reducing t
Externí odkaz:
https://doaj.org/article/2161cc64333c47d29a1c95f031682dc9
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-23 (2021)
Abstract Adequate viral replication in tumor cells is the key to improving the anti-cancer effects of oncolytic adenovirus therapy. In this study, we introduced short hairpin RNAs against death-domain associated protein (Daxx), a repressor of adenovi
Externí odkaz:
https://doaj.org/article/6a774af5ee9d4227a13925858eb8e247
Autor:
Zhezhu Han, Dongxu Kang, Yeonsoo Joo, Jihyun Lee, Geun-Hyeok Oh, Soojin Choi, Suwan Ko, Suyeon Je, Hye Jin Choi, Jae J. Song
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 12, Pp 1-19 (2018)
Cancer: Tipping the signaling balance Reducing the levels of the multifunctional protein transforming growth factor (TGF)-β in cancer cells prevents tumor growth in mice. Previous studies have shown that high levels of TGF-β in cancerous tissue are
Externí odkaz:
https://doaj.org/article/88e935c017ed4a64845a571c7fa1db78
Autor:
Hye Jin Choi, Soo Jin Choi, Dongxu Kang, Geun-Hyeok Oh, Zhezhu Han, Suwan Ko, Suyeon Je, Jihyun Lee, Jae J. Song, Yeonsoo Joo
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 12, Pp 1-19 (2018)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Transforming growth factor (TGF)-β signaling is increasingly recognized as a key driver in cancer. In progressive cancer tissues, TGF-β promotes tumor formation, and its increased expression often correlates with cancer malignancy. In this study, w
Autor:
Jeong A. Hong, Soo Jin Choi, Zhezhu Han, Geun-Hyeok Oh, Yeonsoo Joo, Hye Jin Choi, Ji Hyun Lee, Jae J. Song, Suwan Ko, Rong Xu
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 10, Pp 1-20 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
When the adenoviral protein E1B55K binds death domain-associated protein (Daxx), the proteasome-dependent degradation of Daxx is initiated, and adenoviral replication is effectively maintained. Here, we show that the cellular levels of Daxx differ be
Publikováno v:
Oncotarget
// So Young Kim 1, * , Dongxu Kang 1, 2, * , Hye Jin Choi 3 , Yeonsoo Joo 1, 4 , Joo-Hang Kim 5 , Jae J. Song 1, 4 1 Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Korea 2 Department of Oncology, Affiliated Hospital of Y
Publikováno v:
Apoptosis. 21:351-364
In this study, we demonstrated that survivin downregulation with TRAIL expression greatly enhanced the cytotoxic death of pancreatic cancer cells after gemcitabine treatment. Using real-time RT-PCR, we analyzed five survivin shRNAs to identify the be
Autor:
Won Joo Kim, Jeonghong Shin, Sang Eun Lee, Yeonsoo Joo, Yeon-Soo Kim, Han Sang Kim, Hyongbum Kim, Min Goo Lee, Eun-Ju Choi, Moonkyung Kang, Soonmyung Paik, Jae J. Song, Jae W Choi, Jong In Yook, Minjung Song, Yong Hoon Cha, Jinu Lee, Young Hoon Kim, Eun-Seo Lee
KRAS is the most frequently mutated oncogene in human tumors, and its activating mutations represent important therapeutic targets. The combination of Cas9 and guide RNA from the CRISPR-Cas system recognizes a specific DNA sequence and makes a double
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c231182c63638fe326812b528ec7831a
https://europepmc.org/articles/PMC5848616/
https://europepmc.org/articles/PMC5848616/
Publikováno v:
Cellular Signalling. 25:1288-1300
Curcumin as an anticancer agent was investigated in regards to its ability to regulate the switching of cancer cells from survival to necrotic cell death. At higher concentrations, curcumin induced ROS production leading to JNK and p38 phosphorylatio
Publikováno v:
International Journal of Oncology. 42:1337-1348
To overcome the poor tumor transduction efficiency of adenovirus serotype 5 (Ad5) observed in several types of cancer, the fiber region of Ad5, apart from its tail, was replaced by adenovirus serotype 35 (Ad35). The chimeric Ad5/F35 adenoviral vector